Lower TGFß serum levels and higher frequency of IFNγ-producing T cells during early immune reconstitution in surviving children after allogeneic stem cell transplantation
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Lower TGFß serum levels and higher frequency of IFNγ-producing T cells during early immune reconstitution in surviving children after allogeneic stem cell transplantation. / Wiegering, Verena; Winkler, Beate; Haubitz, Imme; Wölfl, Matthias; Schlegel, Paul G; Eyrich, Matthias.
In: PEDIATR BLOOD CANCER, Vol. 60, No. 1, 01.2013, p. 121-128.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Lower TGFß serum levels and higher frequency of IFNγ-producing T cells during early immune reconstitution in surviving children after allogeneic stem cell transplantation
AU - Wiegering, Verena
AU - Winkler, Beate
AU - Haubitz, Imme
AU - Wölfl, Matthias
AU - Schlegel, Paul G
AU - Eyrich, Matthias
N1 - Copyright © 2012 Wiley Periodicals, Inc.
PY - 2013/1
Y1 - 2013/1
N2 - BACKGROUND: Allogeneic hematopoietic stem cell transplantation (SCT) is increasingly used as a salvage therapy for patients with high-risk malignancies as well as life-threatening non-malignant diseases. However, only limited data about the association between outcome and functional parameters of recovering lymphocytes are available so far.PROCEDURES: In this prospective study of 19 pediatric SCT recipients, we serially evaluated immune parameters quantitatively and qualitatively before and throughout allogeneic SCT. These data were analyzed with respect to survival.RESULTS: Age, gender, GvHD, and type of graft were not different between surviving and non-surviving patients. Notably, in our cohort there was no case of transplant-related or infectious mortality. However, with the exception of two patients with advanced MDS, all patients not in complete remission (CR) relapsed in addition to three patients in higher CR (n = 7). All seven patients relapsing after allogeneic SCT later succumbed to their disease recurrence. Uni- and multivariate analysis showed that relapsing patients had higher TGFß serum levels as well as lower percentages of IFNγ-producing T cells before and early after transplantation. Furthermore, relapsing patients had a further decline in their thymic function between day 60 and 120 whereas non-relapsing patients already showed increasing TREC values during this time interval.CONCLUSIONS: Collectively, patients who later relapse show a different pattern of immune reconstitution before and at early time points post-transplantation.
AB - BACKGROUND: Allogeneic hematopoietic stem cell transplantation (SCT) is increasingly used as a salvage therapy for patients with high-risk malignancies as well as life-threatening non-malignant diseases. However, only limited data about the association between outcome and functional parameters of recovering lymphocytes are available so far.PROCEDURES: In this prospective study of 19 pediatric SCT recipients, we serially evaluated immune parameters quantitatively and qualitatively before and throughout allogeneic SCT. These data were analyzed with respect to survival.RESULTS: Age, gender, GvHD, and type of graft were not different between surviving and non-surviving patients. Notably, in our cohort there was no case of transplant-related or infectious mortality. However, with the exception of two patients with advanced MDS, all patients not in complete remission (CR) relapsed in addition to three patients in higher CR (n = 7). All seven patients relapsing after allogeneic SCT later succumbed to their disease recurrence. Uni- and multivariate analysis showed that relapsing patients had higher TGFß serum levels as well as lower percentages of IFNγ-producing T cells before and early after transplantation. Furthermore, relapsing patients had a further decline in their thymic function between day 60 and 120 whereas non-relapsing patients already showed increasing TREC values during this time interval.CONCLUSIONS: Collectively, patients who later relapse show a different pattern of immune reconstitution before and at early time points post-transplantation.
KW - Adolescent
KW - Adult
KW - Child
KW - Child, Preschool
KW - Female
KW - Hematopoietic Stem Cell Transplantation
KW - Humans
KW - Infant
KW - Interferon-gamma/biosynthesis
KW - Male
KW - Multivariate Analysis
KW - Prospective Studies
KW - Survival Analysis
KW - T-Lymphocytes/immunology
KW - Transforming Growth Factor beta/blood
KW - Transplantation, Homologous
U2 - 10.1002/pbc.24208
DO - 10.1002/pbc.24208
M3 - SCORING: Journal article
C2 - 22623061
VL - 60
SP - 121
EP - 128
JO - PEDIATR BLOOD CANCER
JF - PEDIATR BLOOD CANCER
SN - 1545-5009
IS - 1
ER -
