Long-range synchrony of γ oscillations and auditory hallucination symptoms in schizophrenia.
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Long-range synchrony of γ oscillations and auditory hallucination symptoms in schizophrenia. / Mulert, Christoph; Kirsch, V; Pascual-Marqui, Roberto; McCarley, Robert W; Spencer, Kevin M.
In: INT J PSYCHOPHYSIOL, Vol. 79, No. 1, 1, 2011, p. 55-63.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Long-range synchrony of γ oscillations and auditory hallucination symptoms in schizophrenia.
AU - Mulert, Christoph
AU - Kirsch, V
AU - Pascual-Marqui, Roberto
AU - McCarley, Robert W
AU - Spencer, Kevin M
PY - 2011
Y1 - 2011
N2 - Phase locking in the gamma-band range has been shown to be diminished in patients with schizophrenia. Moreover, there have been reports of positive correlations between phase locking in the gamma-band range and positive symptoms, especially hallucinations. The aim of the present study was to use a new methodological approach in order to investigate gamma-band phase synchronization between the left and right auditory cortex in patients with schizophrenia and its relationship to auditory hallucinations. Subjects were 18 patients with chronic schizophrenia (SZ) and 16 healthy control (HC) subjects. Auditory hallucination symptom scores were obtained using the Scale for the Assessment of Positive Symptoms. Stimuli were 40-Hz binaural click trains. The generators of the 40Hz-ASSR were localized using eLORETA and based on the computed intracranial signals lagged interhemispheric phase locking between primary and secondary auditory cortices was analyzed. Current source density of the 40 ASSR response was significantly diminished in SZ in comparison to HC in the right superior and middle temporal gyrus (p<0.05). Interhemispheric phase locking was reduced in SZ in comparison to HC for the primary auditory cortices (p<0.05) but not in the secondary auditory cortices. A significant positive correlation was found between auditory hallucination symptom scores and phase synchronization between the primary auditory cortices (p<0.05, corrected for multiple testing) but not for the secondary auditory cortices. These results suggest that long-range synchrony of gamma oscillations is disturbed in schizophrenia and that this deficit is related to clinical symptoms such as auditory hallucinations.
AB - Phase locking in the gamma-band range has been shown to be diminished in patients with schizophrenia. Moreover, there have been reports of positive correlations between phase locking in the gamma-band range and positive symptoms, especially hallucinations. The aim of the present study was to use a new methodological approach in order to investigate gamma-band phase synchronization between the left and right auditory cortex in patients with schizophrenia and its relationship to auditory hallucinations. Subjects were 18 patients with chronic schizophrenia (SZ) and 16 healthy control (HC) subjects. Auditory hallucination symptom scores were obtained using the Scale for the Assessment of Positive Symptoms. Stimuli were 40-Hz binaural click trains. The generators of the 40Hz-ASSR were localized using eLORETA and based on the computed intracranial signals lagged interhemispheric phase locking between primary and secondary auditory cortices was analyzed. Current source density of the 40 ASSR response was significantly diminished in SZ in comparison to HC in the right superior and middle temporal gyrus (p<0.05). Interhemispheric phase locking was reduced in SZ in comparison to HC for the primary auditory cortices (p<0.05) but not in the secondary auditory cortices. A significant positive correlation was found between auditory hallucination symptom scores and phase synchronization between the primary auditory cortices (p<0.05, corrected for multiple testing) but not for the secondary auditory cortices. These results suggest that long-range synchrony of gamma oscillations is disturbed in schizophrenia and that this deficit is related to clinical symptoms such as auditory hallucinations.
KW - Adult
KW - Humans
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Time Factors
KW - Brain Waves/physiology
KW - Acoustic Stimulation/methods
KW - Auditory Cortex/physiopathology
KW - Electroencephalography/methods
KW - Hallucinations/complications/physiopathology
KW - Schizophrenia/complications/physiopathology
KW - Adult
KW - Humans
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Time Factors
KW - Brain Waves/physiology
KW - Acoustic Stimulation/methods
KW - Auditory Cortex/physiopathology
KW - Electroencephalography/methods
KW - Hallucinations/complications/physiopathology
KW - Schizophrenia/complications/physiopathology
M3 - SCORING: Journal article
VL - 79
SP - 55
EP - 63
JO - INT J PSYCHOPHYSIOL
JF - INT J PSYCHOPHYSIOL
SN - 0167-8760
IS - 1
M1 - 1
ER -
