Longitudinal studies of cognition in first episode psychosis
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Longitudinal studies of cognition in first episode psychosis : a systematic review of the literature. / Bozikas, Vasilis P; Andreou, Christina.
In: AUST NZ J PSYCHIAT, Vol. 45, No. 2, 01.02.2011, p. 93-108.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Longitudinal studies of cognition in first episode psychosis
T2 - a systematic review of the literature
AU - Bozikas, Vasilis P
AU - Andreou, Christina
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Although cognitive deficits are recognized as a core feature in schizophrenia, their evolution over the course of the illness is still debated. Longitudinal studies of cognition in patients after a first episode of psychosis (FEP) provide extremely useful information, in that they include an adequate and realistic baseline measure of cognitive performance, while at the same time minimizing the effect of confounding variables associated with chronicity. The aim of this systematic review was to summarize findings of studies assessing the longitudinal course of neuropsychological deficits in patients with FEP for durations of at least one year. Overall, the neuropsychological deficits that are present following a first episode of psychosis appeared to remain stable over time for periods of up to ten years, the only possible exception being verbal memory deficits, where there is some evidence of further deterioration over the long term. However, further studies are needed to confirm this conclusion, especially in the (somewhat inconsistently defined) domain of executive function. Improvements in psychopathology appear to positively influence the course of cognitive deficits, although the effects of antipsychotic medication are not as clear.
AB - Although cognitive deficits are recognized as a core feature in schizophrenia, their evolution over the course of the illness is still debated. Longitudinal studies of cognition in patients after a first episode of psychosis (FEP) provide extremely useful information, in that they include an adequate and realistic baseline measure of cognitive performance, while at the same time minimizing the effect of confounding variables associated with chronicity. The aim of this systematic review was to summarize findings of studies assessing the longitudinal course of neuropsychological deficits in patients with FEP for durations of at least one year. Overall, the neuropsychological deficits that are present following a first episode of psychosis appeared to remain stable over time for periods of up to ten years, the only possible exception being verbal memory deficits, where there is some evidence of further deterioration over the long term. However, further studies are needed to confirm this conclusion, especially in the (somewhat inconsistently defined) domain of executive function. Improvements in psychopathology appear to positively influence the course of cognitive deficits, although the effects of antipsychotic medication are not as clear.
KW - Cognition Disorders
KW - Disease Progression
KW - Humans
KW - Longitudinal Studies
KW - Schizophrenia
KW - Schizophrenic Psychology
U2 - 10.3109/00048674.2010.541418
DO - 10.3109/00048674.2010.541418
M3 - SCORING: Journal article
C2 - 21320033
VL - 45
SP - 93
EP - 108
JO - AUST NZ J PSYCHIAT
JF - AUST NZ J PSYCHIAT
SN - 0004-8674
IS - 2
ER -