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Ionizing radiation-induced DNA strand breaks and γ-H2AXγ-H2AX foci in cells exposed to nitric oxide

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Ionizing radiation-induced DNA strand breaks and γ-H2AXγ-H2AX foci in cells exposed to nitric oxide. / Rothkamm, Kai; Burdak-Rothkamm, Susanne.

In: Methods Mol Biol, Vol. 704, 2011, p. 17-25.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rothkamm, K & Burdak-Rothkamm, S 2011, 'Ionizing radiation-induced DNA strand breaks and γ-H2AXγ-H2AX foci in cells exposed to nitric oxide', Methods Mol Biol, vol. 704, pp. 17-25. https://doi.org/10.1007/978-1-61737-964-2_2

APA

Rothkamm, K., & Burdak-Rothkamm, S. (2011). Ionizing radiation-induced DNA strand breaks and γ-H2AXγ-H2AX foci in cells exposed to nitric oxide. Methods Mol Biol, 704, 17-25. https://doi.org/10.1007/978-1-61737-964-2_2

Vancouver

Rothkamm K, Burdak-Rothkamm S. Ionizing radiation-induced DNA strand breaks and γ-H2AXγ-H2AX foci in cells exposed to nitric oxide. Methods Mol Biol. 2011;704:17-25. https://doi.org/10.1007/978-1-61737-964-2_2

Bibtex

@article{a3aadbc774d540f596d6f9319d8a0407,
title = "Ionizing radiation-induced DNA strand breaks and γ-H2AXγ-H2AX foci in cells exposed to nitric oxide",
abstract = "A number of studies have demonstrated that nitric oxide enhances radiosensitivity of anoxic and hypoxic cells in vitro and in vivo, and some evidence points to a role for DNA damage and repair in this phenomenon. We have recently observed that nitric oxide enhances the formation of DNA single- and double-strand breaks following ionising irradiation, measured by the alkaline comet assay and immunofluorescence microscopy for γ-H2AXγ-H2AX.",
keywords = "Animals, Cells, Cultured, Comet Assay, Cricetinae, Cricetulus, DNA Breaks/drug effects, Histones/metabolism, Humans, Microscopy, Fluorescence, Nitric Oxide/pharmacology, Radiation, Ionizing",
author = "Kai Rothkamm and Susanne Burdak-Rothkamm",
year = "2011",
doi = "10.1007/978-1-61737-964-2_2",
language = "English",
volume = "704",
pages = "17--25",
journal = "Methods Mol Biol",
issn = "1064-3745",
publisher = "Humana Press",

}

RIS

TY - JOUR

T1 - Ionizing radiation-induced DNA strand breaks and γ-H2AXγ-H2AX foci in cells exposed to nitric oxide

AU - Rothkamm, Kai

AU - Burdak-Rothkamm, Susanne

PY - 2011

Y1 - 2011

N2 - A number of studies have demonstrated that nitric oxide enhances radiosensitivity of anoxic and hypoxic cells in vitro and in vivo, and some evidence points to a role for DNA damage and repair in this phenomenon. We have recently observed that nitric oxide enhances the formation of DNA single- and double-strand breaks following ionising irradiation, measured by the alkaline comet assay and immunofluorescence microscopy for γ-H2AXγ-H2AX.

AB - A number of studies have demonstrated that nitric oxide enhances radiosensitivity of anoxic and hypoxic cells in vitro and in vivo, and some evidence points to a role for DNA damage and repair in this phenomenon. We have recently observed that nitric oxide enhances the formation of DNA single- and double-strand breaks following ionising irradiation, measured by the alkaline comet assay and immunofluorescence microscopy for γ-H2AXγ-H2AX.

KW - Animals

KW - Cells, Cultured

KW - Comet Assay

KW - Cricetinae

KW - Cricetulus

KW - DNA Breaks/drug effects

KW - Histones/metabolism

KW - Humans

KW - Microscopy, Fluorescence

KW - Nitric Oxide/pharmacology

KW - Radiation, Ionizing

U2 - 10.1007/978-1-61737-964-2_2

DO - 10.1007/978-1-61737-964-2_2

M3 - SCORING: Journal article

C2 - 21161626

VL - 704

SP - 17

EP - 25

JO - Methods Mol Biol

JF - Methods Mol Biol

SN - 1064-3745

ER -