Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

Bettina A Mayer; Markus Rehberg; Annette Erhardt; Alexander Wolf; Christoph A Reichel; Michael Kracht; Fritz Krombach; Gisa Tiegs; Stefan Zahler; Angelika M Vollmar; Robert Fürst

Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

Standard

Inhibitor of apoptosis proteins as novel targets in inflammatory processes. / Mayer, Bettina A; Rehberg, Markus; Erhardt, Annette; Wolf, Alexander; Reichel, Christoph A; Kracht, Michael; Krombach, Fritz; Tiegs, Gisa; Zahler, Stefan; Vollmar, Angelika M; Fürst, Robert.

In: ARTERIOSCL THROM VAS, Vol. 31, No. 10, 10, 2011, p. 2240-2250.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mayer, BA, Rehberg, M, Erhardt, A, Wolf, A, Reichel, CA, Kracht, M, Krombach, F, Tiegs, G, Zahler, S, Vollmar, AM & Fürst, R 2011, 'Inhibitor of apoptosis proteins as novel targets in inflammatory processes.', ARTERIOSCL THROM VAS, vol. 31, no. 10, 10, pp. 2240-2250. <http://www.ncbi.nlm.nih.gov/pubmed/21817100?dopt=Citation>

APA

Mayer, B. A., Rehberg, M., Erhardt, A., Wolf, A., Reichel, C. A., Kracht, M., Krombach, F., Tiegs, G., Zahler, S., Vollmar, A. M., & Fürst, R. (2011). Inhibitor of apoptosis proteins as novel targets in inflammatory processes. ARTERIOSCL THROM VAS, 31(10), 2240-2250. [10]. http://www.ncbi.nlm.nih.gov/pubmed/21817100?dopt=Citation

Vancouver

Mayer BA, Rehberg M, Erhardt A, Wolf A, Reichel CA, Kracht M et al. Inhibitor of apoptosis proteins as novel targets in inflammatory processes. ARTERIOSCL THROM VAS. 2011;31(10):2240-2250. 10.

Bibtex

@article{1602d7eae578469faec4de967128fa54,

title = "Inhibitor of apoptosis proteins as novel targets in inflammatory processes.",

abstract = "Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents. Interestingly, IAPs participate in the inflammation-associated TNF receptor signaling complex and regulate NF?B signaling. This raises the question about the role of IAPs in inflammation. Here, we investigated the anti-inflammatory potential of IAP inhibitors and the role of IAPs in inflammatory processes of endothelial cells.",

keywords = "Animals, Humans, Male, Time Factors, Disease Models, Animal, Mice, Mice, Inbred C57BL, Protein Processing, Post-Translational, Hela Cells, Enzyme Activation, Transfection, Dose-Response Relationship, Drug, Apoptosis/drug effects, Tumor Necrosis Factor-alpha/metabolism, NF-kappa B/metabolism, RNA Interference, Ubiquitination, Anti-Inflammatory Agents/*pharmacology, Arthritis, Experimental/immunology/metabolism/*prevention & control, Caspases/metabolism, Cell Adhesion/drug effects, Concanavalin A, Drug-Induced Liver Injury/immunology/metabolism/*prevention & control, Endothelial Cells/*drug effects/immunology/metabolism, Inhibitor of Apoptosis Proteins/*antagonists & inhibitors/genetics/metabolism, Intercellular Adhesion Molecule-1/metabolism, JNK Mitogen-Activated Protein Kinases/metabolism, Leukocytes/drug effects/immunology/metabolism, MAP Kinase Kinase Kinases/metabolism, Proteasome Endopeptidase Complex/metabolism, Serum Albumin, Bovine, TNF Receptor-Associated Factor 2/metabolism, TNF Receptor-Associated Factor 5/metabolism, Transendothelial and Transepithelial Migration/drug effects, p38 Mitogen-Activated Protein Kinases/metabolism, Animals, Humans, Male, Time Factors, Disease Models, Animal, Mice, Mice, Inbred C57BL, Protein Processing, Post-Translational, Hela Cells, Enzyme Activation, Transfection, Dose-Response Relationship, Drug, Apoptosis/drug effects, Tumor Necrosis Factor-alpha/metabolism, NF-kappa B/metabolism, RNA Interference, Ubiquitination, Anti-Inflammatory Agents/*pharmacology, Arthritis, Experimental/immunology/metabolism/*prevention & control, Caspases/metabolism, Cell Adhesion/drug effects, Concanavalin A, Drug-Induced Liver Injury/immunology/metabolism/*prevention & control, Endothelial Cells/*drug effects/immunology/metabolism, Inhibitor of Apoptosis Proteins/*antagonists & inhibitors/genetics/metabolism, Intercellular Adhesion Molecule-1/metabolism, JNK Mitogen-Activated Protein Kinases/metabolism, Leukocytes/drug effects/immunology/metabolism, MAP Kinase Kinase Kinases/metabolism, Proteasome Endopeptidase Complex/metabolism, Serum Albumin, Bovine, TNF Receptor-Associated Factor 2/metabolism, TNF Receptor-Associated Factor 5/metabolism, Transendothelial and Transepithelial Migration/drug effects, p38 Mitogen-Activated Protein Kinases/metabolism",

author = "Mayer, {Bettina A} and Markus Rehberg and Annette Erhardt and Alexander Wolf and Reichel, {Christoph A} and Michael Kracht and Fritz Krombach and Gisa Tiegs and Stefan Zahler and Vollmar, {Angelika M} and Robert F{\"u}rst",

year = "2011",

language = "English",

volume = "31",

pages = "2240--2250",

journal = "ARTERIOSCL THROM VAS",

issn = "1079-5642",

publisher = "Lippincott Williams and Wilkins",

number = "10",

}

RIS

TY - JOUR

T1 - Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

AU - Mayer, Bettina A

AU - Rehberg, Markus

AU - Erhardt, Annette

AU - Wolf, Alexander

AU - Reichel, Christoph A

AU - Kracht, Michael

AU - Krombach, Fritz

AU - Tiegs, Gisa

AU - Zahler, Stefan

AU - Vollmar, Angelika M

AU - Fürst, Robert

PY - 2011

Y1 - 2011

N2 - Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents. Interestingly, IAPs participate in the inflammation-associated TNF receptor signaling complex and regulate NF?B signaling. This raises the question about the role of IAPs in inflammation. Here, we investigated the anti-inflammatory potential of IAP inhibitors and the role of IAPs in inflammatory processes of endothelial cells.

AB - Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents. Interestingly, IAPs participate in the inflammation-associated TNF receptor signaling complex and regulate NF?B signaling. This raises the question about the role of IAPs in inflammation. Here, we investigated the anti-inflammatory potential of IAP inhibitors and the role of IAPs in inflammatory processes of endothelial cells.

KW - Animals

KW - Humans

KW - Male

KW - Time Factors

KW - Disease Models, Animal

KW - Mice

KW - Mice, Inbred C57BL

KW - Protein Processing, Post-Translational

KW - Hela Cells

KW - Enzyme Activation

KW - Transfection

KW - Dose-Response Relationship, Drug

KW - Apoptosis/drug effects

KW - Tumor Necrosis Factor-alpha/metabolism

KW - NF-kappa B/metabolism

KW - RNA Interference

KW - Ubiquitination

KW - Anti-Inflammatory Agents/pharmacology

KW - Arthritis, Experimental/immunology/metabolism/prevention & control

KW - Caspases/metabolism

KW - Cell Adhesion/drug effects

KW - Concanavalin A

KW - Drug-Induced Liver Injury/immunology/metabolism/prevention & control

KW - Endothelial Cells/drug effects/immunology/metabolism

KW - Inhibitor of Apoptosis Proteins/antagonists & inhibitors/genetics/metabolism

KW - Intercellular Adhesion Molecule-1/metabolism

KW - JNK Mitogen-Activated Protein Kinases/metabolism

KW - Leukocytes/drug effects/immunology/metabolism

KW - MAP Kinase Kinase Kinases/metabolism

KW - Proteasome Endopeptidase Complex/metabolism

KW - Serum Albumin, Bovine

KW - TNF Receptor-Associated Factor 2/metabolism

KW - TNF Receptor-Associated Factor 5/metabolism

KW - Transendothelial and Transepithelial Migration/drug effects

KW - p38 Mitogen-Activated Protein Kinases/metabolism