Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis.
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Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis. / Hawellek, David; Hipp, Jörg; Lewis, Christopher M; Corbetta, Maurizio; Engel, Andreas K.
In: P NATL ACAD SCI USA, Vol. 108, No. 47, 47, 2011, p. 19066-19071.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis.
AU - Hawellek, David
AU - Hipp, Jörg
AU - Lewis, Christopher M
AU - Corbetta, Maurizio
AU - Engel, Andreas K.
PY - 2011
Y1 - 2011
N2 - Correlations in spontaneous brain activity provide powerful access to large-scale organizational principles of the CNS. However, making inferences about cognitive processes requires a detailed understanding of the link between these couplings and the structural integrity of the CNS. We studied the impact of multiple sclerosis, which leads to the severe disintegration of the central white matter, on functional connectivity patterns in spontaneous cortical activity. Using a data driven approach based on the strength of a salient pattern of cognitive pathology, we identified distinct networks that exhibit increases in functional connectivity despite the presence of strong and diffuse reductions of the central white-matter integrity. The default mode network emerged as a core target of these connectivity modulations, showing enhanced functional coupling in bilateral inferior parietal cortex, posterior cingulate, and medial prefrontal cortex. These findings imply a complex and diverging relation of anatomical and functional connectivity in early multiple sclerosis and, thus, add an important observation for understanding how cognitive abilities and CNS integrity may be reflected in the intrinsic covariance of functional signals.
AB - Correlations in spontaneous brain activity provide powerful access to large-scale organizational principles of the CNS. However, making inferences about cognitive processes requires a detailed understanding of the link between these couplings and the structural integrity of the CNS. We studied the impact of multiple sclerosis, which leads to the severe disintegration of the central white matter, on functional connectivity patterns in spontaneous cortical activity. Using a data driven approach based on the strength of a salient pattern of cognitive pathology, we identified distinct networks that exhibit increases in functional connectivity despite the presence of strong and diffuse reductions of the central white-matter integrity. The default mode network emerged as a core target of these connectivity modulations, showing enhanced functional coupling in bilateral inferior parietal cortex, posterior cingulate, and medial prefrontal cortex. These findings imply a complex and diverging relation of anatomical and functional connectivity in early multiple sclerosis and, thus, add an important observation for understanding how cognitive abilities and CNS integrity may be reflected in the intrinsic covariance of functional signals.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Neuropsychological Tests
KW - Magnetic Resonance Imaging
KW - Brain Mapping
KW - Anisotropy
KW - Brain/physiology
KW - Cognition Disorders/etiology/pathology
KW - Diffusion Tensor Imaging
KW - Models, Neurological
KW - Multiple Sclerosis/complications/pathology
KW - Neural Pathways/pathology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Neuropsychological Tests
KW - Magnetic Resonance Imaging
KW - Brain Mapping
KW - Anisotropy
KW - Brain/physiology
KW - Cognition Disorders/etiology/pathology
KW - Diffusion Tensor Imaging
KW - Models, Neurological
KW - Multiple Sclerosis/complications/pathology
KW - Neural Pathways/pathology
M3 - SCORING: Journal article
VL - 108
SP - 19066
EP - 19071
JO - P NATL ACAD SCI USA
JF - P NATL ACAD SCI USA
SN - 0027-8424
IS - 47
M1 - 47
ER -
