Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry
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Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry. / D'Ascenzo, Fabrizio; Gili, Sebastiano; Bertaina, Maurizio; Iannaccone, Mario; Cammann, Victoria L; Di Vece, Davide; Kato, Ken; Saglietto, Andrea; Szawan, Konrad A; Frangieh, Antonio H; Boffini, Beatrice; Annaratone, Margherita; Sarcon, Annahita; Levinson, Rena A; Franke, Jennifer; Napp, L Christian; Jaguszewski, Milosz; Noutsias, Michel; Münzel, Thomas; Knorr, Maike; Heiner, Susanne; Katus, Hugo A; Burgdorf, Christof; Schunkert, Heribert; Thiele, Holger; Bauersachs, Johann; Tschöpe, Carsten; Pieske, Burkert M; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Cuneo, Alessandro; Jacobshagen, Claudius; Hasenfuß, Gerd; Karakas, Mahir; Koenig, Wolfgang; Rottbauer, Wolfgang; Said, Samir M; Braun-Dullaeus, Ruediger C; Banning, Adrian; Cuculi, Florim; Kobza, Richard; Fischer, Thomas A; Vasankari, Tuija; Airaksinen, K E Juhani; Opolski, Grzegorz; Dworakowski, Rafal; MacCarthy, Philip; Kaiser, Christoph; Osswald, Stefan; Galiuto, Leonarda; Crea, Filippo; Dichtl, Wolfgang; Franz, Wolfgang M; Empen, Klaus; Felix, Stephan B; Delmas, Clément; Lairez, Olivier; El-Battrawy, Ibrahim; Akin, Ibrahim; Borggrefe, Martin; Horowitz, John D; Kozel, Martin; Tousek, Petr; Widimský, Petr; Gilyarova, Ekaterina; Shilova, Alexandra; Gilyarov, Mikhail; Biondi-Zoccai, Giuseppe; Winchester, David E; Ukena, Christian; Neuhaus, Michael; Bax, Jeroen J; Prasad, Abhiram; Di Mario, Carlo; Böhm, Michael; Gasparini, Mauro; Ruschitzka, Frank; Bossone, Eduardo; Citro, Rodolfo; Rinaldi, Mauro; De Ferrari, Gaetano Maria; Lüscher, Thomas; Ghadri, Jelena R; Templin, Christian.
In: EUR J HEART FAIL, Vol. 22, No. 2, 01.02.2020, p. 330-337.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry
AU - D'Ascenzo, Fabrizio
AU - Gili, Sebastiano
AU - Bertaina, Maurizio
AU - Iannaccone, Mario
AU - Cammann, Victoria L
AU - Di Vece, Davide
AU - Kato, Ken
AU - Saglietto, Andrea
AU - Szawan, Konrad A
AU - Frangieh, Antonio H
AU - Boffini, Beatrice
AU - Annaratone, Margherita
AU - Sarcon, Annahita
AU - Levinson, Rena A
AU - Franke, Jennifer
AU - Napp, L Christian
AU - Jaguszewski, Milosz
AU - Noutsias, Michel
AU - Münzel, Thomas
AU - Knorr, Maike
AU - Heiner, Susanne
AU - Katus, Hugo A
AU - Burgdorf, Christof
AU - Schunkert, Heribert
AU - Thiele, Holger
AU - Bauersachs, Johann
AU - Tschöpe, Carsten
AU - Pieske, Burkert M
AU - Rajan, Lawrence
AU - Michels, Guido
AU - Pfister, Roman
AU - Cuneo, Alessandro
AU - Jacobshagen, Claudius
AU - Hasenfuß, Gerd
AU - Karakas, Mahir
AU - Koenig, Wolfgang
AU - Rottbauer, Wolfgang
AU - Said, Samir M
AU - Braun-Dullaeus, Ruediger C
AU - Banning, Adrian
AU - Cuculi, Florim
AU - Kobza, Richard
AU - Fischer, Thomas A
AU - Vasankari, Tuija
AU - Airaksinen, K E Juhani
AU - Opolski, Grzegorz
AU - Dworakowski, Rafal
AU - MacCarthy, Philip
AU - Kaiser, Christoph
AU - Osswald, Stefan
AU - Galiuto, Leonarda
AU - Crea, Filippo
AU - Dichtl, Wolfgang
AU - Franz, Wolfgang M
AU - Empen, Klaus
AU - Felix, Stephan B
AU - Delmas, Clément
AU - Lairez, Olivier
AU - El-Battrawy, Ibrahim
AU - Akin, Ibrahim
AU - Borggrefe, Martin
AU - Horowitz, John D
AU - Kozel, Martin
AU - Tousek, Petr
AU - Widimský, Petr
AU - Gilyarova, Ekaterina
AU - Shilova, Alexandra
AU - Gilyarov, Mikhail
AU - Biondi-Zoccai, Giuseppe
AU - Winchester, David E
AU - Ukena, Christian
AU - Neuhaus, Michael
AU - Bax, Jeroen J
AU - Prasad, Abhiram
AU - Di Mario, Carlo
AU - Böhm, Michael
AU - Gasparini, Mauro
AU - Ruschitzka, Frank
AU - Bossone, Eduardo
AU - Citro, Rodolfo
AU - Rinaldi, Mauro
AU - De Ferrari, Gaetano Maria
AU - Lüscher, Thomas
AU - Ghadri, Jelena R
AU - Templin, Christian
N1 - © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - AIMS: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS).METHODS AND RESULTS: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50-3.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78-1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting.CONCLUSION: In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.
AB - AIMS: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS).METHODS AND RESULTS: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50-3.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78-1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting.CONCLUSION: In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.
KW - Aspirin/therapeutic use
KW - Heart Failure
KW - Humans
KW - Ischemic Attack, Transient
KW - Myocardial Infarction
KW - Platelet Aggregation Inhibitors/therapeutic use
KW - Propensity Score
KW - Recurrence
KW - Registries
KW - Stroke
KW - Takotsubo Cardiomyopathy/drug therapy
KW - Treatment Outcome
U2 - 10.1002/ejhf.1698
DO - 10.1002/ejhf.1698
M3 - SCORING: Journal article
C2 - 31863563
VL - 22
SP - 330
EP - 337
JO - EUR J HEART FAIL
JF - EUR J HEART FAIL
SN - 1388-9842
IS - 2
ER -