IgG4 antibodies and cancer-associated inflammation
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IgG4 antibodies and cancer-associated inflammation : Insights into a novel mechanism of immune escape. / Karagiannis, Panagiotis; Gilbert, Amy E; Nestle, Frank O; Karagiannis, Sophia N.
In: ONCOIMMUNOLOGY, Vol. 2, No. 7, 01.07.2013, p. e24889.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - IgG4 antibodies and cancer-associated inflammation
T2 - Insights into a novel mechanism of immune escape
AU - Karagiannis, Panagiotis
AU - Gilbert, Amy E
AU - Nestle, Frank O
AU - Karagiannis, Sophia N
PY - 2013/7/1
Y1 - 2013/7/1
N2 - The role of B cells and antibodies in cancer is insufficiently understood but is receiving increasing attention. We have recently identified IgG4 as an antibody subclass elicited by melanoma-associated interleukin-10-driven inflammation. In this setting, IgG4 exhibit inefficient immunostimulatory capacity and block the cytotoxic activities of other antibodies. These previously unappreciated mechanisms of immune escape may constitute promising targets for the development of novel anticancer immunotherapies.
AB - The role of B cells and antibodies in cancer is insufficiently understood but is receiving increasing attention. We have recently identified IgG4 as an antibody subclass elicited by melanoma-associated interleukin-10-driven inflammation. In this setting, IgG4 exhibit inefficient immunostimulatory capacity and block the cytotoxic activities of other antibodies. These previously unappreciated mechanisms of immune escape may constitute promising targets for the development of novel anticancer immunotherapies.
U2 - 10.4161/onci.24889
DO - 10.4161/onci.24889
M3 - SCORING: Journal article
C2 - 24073371
VL - 2
SP - e24889
JO - ONCOIMMUNOLOGY
JF - ONCOIMMUNOLOGY
SN - 2162-402X
IS - 7
ER -