IgG4 antibodies and cancer-associated inflammation

  • Panagiotis Karagiannis
  • Amy E Gilbert
  • Frank O Nestle
  • Sophia N Karagiannis

Abstract

The role of B cells and antibodies in cancer is insufficiently understood but is receiving increasing attention. We have recently identified IgG4 as an antibody subclass elicited by melanoma-associated interleukin-10-driven inflammation. In this setting, IgG4 exhibit inefficient immunostimulatory capacity and block the cytotoxic activities of other antibodies. These previously unappreciated mechanisms of immune escape may constitute promising targets for the development of novel anticancer immunotherapies.

Bibliographical data

Original languageEnglish
ISSN2162-402X
DOIs
Publication statusPublished - 01.07.2013
Externally publishedYes
PubMed 24073371