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Identification of quantitative trait loci for murine autoimmune pancreatitis

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Identification of quantitative trait loci for murine autoimmune pancreatitis. / Asghari, Farahnaz; Fitzner, Brit; Holzhüter, Stephanie-Anna; Nizze, Horst; de Castro Marques, Andreia; Müller, Susen; Möller, Steffen; Ibrahim, Saleh M; Jaster, Robert.

In: J MED GENET, Vol. 48, No. 8, 08.2011, p. 557-62.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Asghari, F, Fitzner, B, Holzhüter, S-A, Nizze, H, de Castro Marques, A, Müller, S, Möller, S, Ibrahim, SM & Jaster, R 2011, 'Identification of quantitative trait loci for murine autoimmune pancreatitis', J MED GENET, vol. 48, no. 8, pp. 557-62. https://doi.org/10.1136/jmg.2011.089730

APA

Asghari, F., Fitzner, B., Holzhüter, S-A., Nizze, H., de Castro Marques, A., Müller, S., Möller, S., Ibrahim, S. M., & Jaster, R. (2011). Identification of quantitative trait loci for murine autoimmune pancreatitis. J MED GENET, 48(8), 557-62. https://doi.org/10.1136/jmg.2011.089730

Vancouver

Asghari F, Fitzner B, Holzhüter S-A, Nizze H, de Castro Marques A, Müller S et al. Identification of quantitative trait loci for murine autoimmune pancreatitis. J MED GENET. 2011 Aug;48(8):557-62. https://doi.org/10.1136/jmg.2011.089730

Bibtex

@article{afffa9ccf642488a93e1234ad9974fec,
title = "Identification of quantitative trait loci for murine autoimmune pancreatitis",
abstract = "BACKGROUND AND AIMS: Autoimmune pancreatitis (AIP) represents a rare but clinically relevant cause of pancreatic inflammation. Using MRL/Mp mice as a model of spontaneous AIP, the genetic basis of the disease was studied.METHODS: To identify quantitative trait loci (QTL) of AIP, an advanced intercross line was studied, originating from MRL/MpJ parental mice and the following three mouse strains: Cast (healthy controls), BXD2 (susceptible to collagen induced arthritis), and NZM (a model of lupus erythematosus). This concept was chosen to identify both general autoimmune disease associated loci and AIP specific QTL. Therefore, generation G4 of outbred intercross mice was characterised phenotypically by scoring histopathological changes of the pancreas and genotyped with single nucleotide polymorphism (SNP) arrays. Data were analysed with the R implementation of HAPPY.RESULTS: Five QTLs, correlating with the severity of AIP, were identified. Two of them mapped to chromosome 4 and one to chromosomes 2, 5, and 6, respectively. The QTL on chromosome 6 displays the highest LOD score (5.4) and contains the C-type lectin domain family 4 member a2 in its peak region, which encodes a receptor protein of dendritic cells that has previously been implicated in autoimmune diseases such as Sjogren's syndrome. AIP candidate genes of other QTL's include heterogeneous nuclear ribonucleoprotein A3; nuclear factor, erythroid derived 2, like 2; Sjogren syndrome antigen B; and ubiquitin protein ligase E3 component n-recognin 3.CONCLUSIONS: This study has identified QTLs and putative candidate genes of murine AIP. Their functional role and relevance to human AIP will be studied further.",
keywords = "Animals, Autoimmune Diseases, Crosses, Genetic, Female, Genetic Association Studies, Immunohistochemistry, Male, Mice, Pancreatitis, Phenotype, Quantitative Trait Loci",
author = "Farahnaz Asghari and Brit Fitzner and Stephanie-Anna Holzh{\"u}ter and Horst Nizze and {de Castro Marques}, Andreia and Susen M{\"u}ller and Steffen M{\"o}ller and Ibrahim, {Saleh M} and Robert Jaster",
year = "2011",
month = aug,
doi = "10.1136/jmg.2011.089730",
language = "English",
volume = "48",
pages = "557--62",
journal = "J MED GENET",
issn = "0022-2593",
publisher = "BMJ PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Identification of quantitative trait loci for murine autoimmune pancreatitis

AU - Asghari, Farahnaz

AU - Fitzner, Brit

AU - Holzhüter, Stephanie-Anna

AU - Nizze, Horst

AU - de Castro Marques, Andreia

AU - Müller, Susen

AU - Möller, Steffen

AU - Ibrahim, Saleh M

AU - Jaster, Robert

PY - 2011/8

Y1 - 2011/8

N2 - BACKGROUND AND AIMS: Autoimmune pancreatitis (AIP) represents a rare but clinically relevant cause of pancreatic inflammation. Using MRL/Mp mice as a model of spontaneous AIP, the genetic basis of the disease was studied.METHODS: To identify quantitative trait loci (QTL) of AIP, an advanced intercross line was studied, originating from MRL/MpJ parental mice and the following three mouse strains: Cast (healthy controls), BXD2 (susceptible to collagen induced arthritis), and NZM (a model of lupus erythematosus). This concept was chosen to identify both general autoimmune disease associated loci and AIP specific QTL. Therefore, generation G4 of outbred intercross mice was characterised phenotypically by scoring histopathological changes of the pancreas and genotyped with single nucleotide polymorphism (SNP) arrays. Data were analysed with the R implementation of HAPPY.RESULTS: Five QTLs, correlating with the severity of AIP, were identified. Two of them mapped to chromosome 4 and one to chromosomes 2, 5, and 6, respectively. The QTL on chromosome 6 displays the highest LOD score (5.4) and contains the C-type lectin domain family 4 member a2 in its peak region, which encodes a receptor protein of dendritic cells that has previously been implicated in autoimmune diseases such as Sjogren's syndrome. AIP candidate genes of other QTL's include heterogeneous nuclear ribonucleoprotein A3; nuclear factor, erythroid derived 2, like 2; Sjogren syndrome antigen B; and ubiquitin protein ligase E3 component n-recognin 3.CONCLUSIONS: This study has identified QTLs and putative candidate genes of murine AIP. Their functional role and relevance to human AIP will be studied further.

AB - BACKGROUND AND AIMS: Autoimmune pancreatitis (AIP) represents a rare but clinically relevant cause of pancreatic inflammation. Using MRL/Mp mice as a model of spontaneous AIP, the genetic basis of the disease was studied.METHODS: To identify quantitative trait loci (QTL) of AIP, an advanced intercross line was studied, originating from MRL/MpJ parental mice and the following three mouse strains: Cast (healthy controls), BXD2 (susceptible to collagen induced arthritis), and NZM (a model of lupus erythematosus). This concept was chosen to identify both general autoimmune disease associated loci and AIP specific QTL. Therefore, generation G4 of outbred intercross mice was characterised phenotypically by scoring histopathological changes of the pancreas and genotyped with single nucleotide polymorphism (SNP) arrays. Data were analysed with the R implementation of HAPPY.RESULTS: Five QTLs, correlating with the severity of AIP, were identified. Two of them mapped to chromosome 4 and one to chromosomes 2, 5, and 6, respectively. The QTL on chromosome 6 displays the highest LOD score (5.4) and contains the C-type lectin domain family 4 member a2 in its peak region, which encodes a receptor protein of dendritic cells that has previously been implicated in autoimmune diseases such as Sjogren's syndrome. AIP candidate genes of other QTL's include heterogeneous nuclear ribonucleoprotein A3; nuclear factor, erythroid derived 2, like 2; Sjogren syndrome antigen B; and ubiquitin protein ligase E3 component n-recognin 3.CONCLUSIONS: This study has identified QTLs and putative candidate genes of murine AIP. Their functional role and relevance to human AIP will be studied further.

KW - Animals

KW - Autoimmune Diseases

KW - Crosses, Genetic

KW - Female

KW - Genetic Association Studies

KW - Immunohistochemistry

KW - Male

KW - Mice

KW - Pancreatitis

KW - Phenotype

KW - Quantitative Trait Loci

U2 - 10.1136/jmg.2011.089730

DO - 10.1136/jmg.2011.089730

M3 - SCORING: Journal article

C2 - 21709168

VL - 48

SP - 557

EP - 562

JO - J MED GENET

JF - J MED GENET

SN - 0022-2593

IS - 8

ER -