Hypermetabolism in 18F-FDG PET predicts favorable outcome following decompressive surgery in patients with degenerative cervical myelopathy
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Hypermetabolism in 18F-FDG PET predicts favorable outcome following decompressive surgery in patients with degenerative cervical myelopathy. / Floeth, Frank W; Galldiks, Norbert; Eicker, Sven; Stoffels, Gabriele; Herdmann, Jörg; Steiger, Hans-Jakob; Antoch, Gerald; Rhee, Sascha; Langen, Karl-Josef.
In: J NUCL MED, Vol. 54, No. 9, 09.2013, p. 1577-83.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Hypermetabolism in 18F-FDG PET predicts favorable outcome following decompressive surgery in patients with degenerative cervical myelopathy
AU - Floeth, Frank W
AU - Galldiks, Norbert
AU - Eicker, Sven
AU - Stoffels, Gabriele
AU - Herdmann, Jörg
AU - Steiger, Hans-Jakob
AU - Antoch, Gerald
AU - Rhee, Sascha
AU - Langen, Karl-Josef
PY - 2013/9
Y1 - 2013/9
N2 - UNLABELLED: The aim of this study was to prospectively assess the regional changes of glucose metabolism of the cervical spinal cord in patients with degenerative cervical spine stenosis and symptomatic cervical myelopathy after decompressive surgery using (18)F-FDG PET.METHODS: Twenty patients with symptomatic degenerative monosegmental cervical stenosis with neuroradiologic signs of spinal cord compression underwent decompressive surgery. The clinical course using a functional status score (Japanese Orthopedic Association [JOA] score), (18)F-FDG uptake, and MR imaging were assessed before and at follow-up 12 mo after surgery. Pre- and postoperative changes of (18)F-FDG PET were correlated to the patients' clinical outcome.RESULTS: Ten patients demonstrated preoperatively a focally increased (18)F-FDG uptake at the level of the stenosis. At follow-up, the uptake declined significantly (P = 0.008), and a significant improvement of JOA scores (P < 0.001) could be observed. The remaining 10 patients were characterized preoperatively by an inconspicuous glucose uptake at the level of cord compression in combination with a poststenotic decrease of (18)F-FDG uptake. At follow-up, both JOA scores and (18)F-FDG uptake changed insignificantly.CONCLUSION: Focal glucose hypermetabolism at the level of cervical spinal cord compression may predict an improved outcome after surgical decompression. Thus, this finding on (18)F-FDG PET suggests a functional damage in a reversible phase of cervical myelopathy.
AB - UNLABELLED: The aim of this study was to prospectively assess the regional changes of glucose metabolism of the cervical spinal cord in patients with degenerative cervical spine stenosis and symptomatic cervical myelopathy after decompressive surgery using (18)F-FDG PET.METHODS: Twenty patients with symptomatic degenerative monosegmental cervical stenosis with neuroradiologic signs of spinal cord compression underwent decompressive surgery. The clinical course using a functional status score (Japanese Orthopedic Association [JOA] score), (18)F-FDG uptake, and MR imaging were assessed before and at follow-up 12 mo after surgery. Pre- and postoperative changes of (18)F-FDG PET were correlated to the patients' clinical outcome.RESULTS: Ten patients demonstrated preoperatively a focally increased (18)F-FDG uptake at the level of the stenosis. At follow-up, the uptake declined significantly (P = 0.008), and a significant improvement of JOA scores (P < 0.001) could be observed. The remaining 10 patients were characterized preoperatively by an inconspicuous glucose uptake at the level of cord compression in combination with a poststenotic decrease of (18)F-FDG uptake. At follow-up, both JOA scores and (18)F-FDG uptake changed insignificantly.CONCLUSION: Focal glucose hypermetabolism at the level of cervical spinal cord compression may predict an improved outcome after surgical decompression. Thus, this finding on (18)F-FDG PET suggests a functional damage in a reversible phase of cervical myelopathy.
KW - Aged
KW - Aged, 80 and over
KW - Cervical Vertebrae
KW - Decompression, Surgical
KW - Female
KW - Fluorodeoxyglucose F18
KW - Humans
KW - Male
KW - Middle Aged
KW - Outcome Assessment (Health Care)
KW - Prognosis
KW - Radiopharmaceuticals
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Spinal Cord Compression
KW - Spinal Stenosis
KW - Treatment Outcome
U2 - 10.2967/jnumed.112.113183
DO - 10.2967/jnumed.112.113183
M3 - SCORING: Journal article
C2 - 23918736
VL - 54
SP - 1577
EP - 1583
JO - J NUCL MED
JF - J NUCL MED
SN - 0161-5505
IS - 9
ER -
