Research ExplorerPublicationsHeart re-transplantation in Eurotransplant

Heart re-transplantation in Eurotransplant

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Heart re-transplantation in Eurotransplant. / Smits, Jacqueline M; De Pauw, Michel; Schulz, Uwe; Van Cleemput, Johan; Raake, Philip; Knezevic, Ivan; Caliskan, Kadir; Sutlic, Zeljko; Knosalla, Christoph; Schoenrath, Felix; Szabolcs, Zoltan; Gottlieb, Jens; Hagl, Christian; Doesch, Andreas; Baric, Davor; Rudez, Igor; Strelniece, Agita; De Vries, Erwin; Green, Dave; Samuel, Undine; Milicic, Davor; Hartyanszky, Istvan; Berchtold-Herz, Michael; Schulze, P Christian; Mohr, Friedrich; Meiser, Bruno; Haverich, Axel; Reichenspurner, Hermann; Gummert, Jan; Laufer, Guenter; Zuckermann, Andreas.

In: TRANSPL INT, Vol. 31, No. 11, 11.2018, p. 1223-1232.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Smits, JM, De Pauw, M, Schulz, U, Van Cleemput, J, Raake, P, Knezevic, I, Caliskan, K, Sutlic, Z, Knosalla, C, Schoenrath, F, Szabolcs, Z, Gottlieb, J, Hagl, C, Doesch, A, Baric, D, Rudez, I, Strelniece, A, De Vries, E, Green, D, Samuel, U, Milicic, D, Hartyanszky, I, Berchtold-Herz, M, Schulze, PC, Mohr, F, Meiser, B, Haverich, A, Reichenspurner, H, Gummert, J, Laufer, G & Zuckermann, A 2018, 'Heart re-transplantation in Eurotransplant', TRANSPL INT, vol. 31, no. 11, pp. 1223-1232. https://doi.org/10.1111/tri.13289

APA

Smits, J. M., De Pauw, M., Schulz, U., Van Cleemput, J., Raake, P., Knezevic, I., Caliskan, K., Sutlic, Z., Knosalla, C., Schoenrath, F., Szabolcs, Z., Gottlieb, J., Hagl, C., Doesch, A., Baric, D., Rudez, I., Strelniece, A., De Vries, E., Green, D., ... Zuckermann, A. (2018). Heart re-transplantation in Eurotransplant. TRANSPL INT, 31(11), 1223-1232. https://doi.org/10.1111/tri.13289

Vancouver

Smits JM, De Pauw M, Schulz U, Van Cleemput J, Raake P, Knezevic I et al. Heart re-transplantation in Eurotransplant. TRANSPL INT. 2018 Nov;31(11):1223-1232. https://doi.org/10.1111/tri.13289

Bibtex

@article{d8e58d11c36743dead022545e0846786,
title = "Heart re-transplantation in Eurotransplant",
abstract = "Internationally 3% of the donor hearts are distributed to re-transplant patients. In Eurotransplant, only patients with a primary graft dysfunction (PGD) within 1 week after heart transplantation (HTX) are indicated for high urgency listing. The aim of this study is to provide evidence for the discussion on whether these patients should still be allocated with priority. All consecutive HTX performed in the period 1981-2015 were included. Multivariate Cox' model was built including: donor and recipient age and gender, ischaemia time, recipient diagnose, urgency status and era. The study population included 18 490 HTX, of these 463 (2.6%) were repeat transplants. The major indications for re-HTX were cardiac allograft vasculopathy (CAV) (50%), PGD (26%) and acute rejection (21%). In a multivariate model, compared with first HTX hazards ratio and 95% confidence interval for repeat HTX were 2.27 (1.83-2.82) for PGD, 2.24 (1.76-2.85) for acute rejection and 1.22 (1.00-1.48) for CAV (P < 0.0001). Outcome after cardiac re-HTX strongly depends on the indication for re-HTX with acceptable outcomes for CAV. In contrast, just 47.5% of all hearts transplanted in patients who were re-transplanted for PGD still functioned at 1-month post-transplant. Alternative options like VA-ECMO should be first offered before opting for acute re-transplantation.",
keywords = "Adult, Europe, Female, Graft Rejection/epidemiology, Heart Diseases/surgery, Heart Failure/surgery, Heart Transplantation/statistics & numerical data, Humans, Male, Middle Aged, Multivariate Analysis, Primary Graft Dysfunction/epidemiology, Proportional Hazards Models, Reoperation/statistics & numerical data, Retrospective Studies, Time Factors, Tissue Donors, Young Adult",
author = "Smits, {Jacqueline M} and {De Pauw}, Michel and Uwe Schulz and {Van Cleemput}, Johan and Philip Raake and Ivan Knezevic and Kadir Caliskan and Zeljko Sutlic and Christoph Knosalla and Felix Schoenrath and Zoltan Szabolcs and Jens Gottlieb and Christian Hagl and Andreas Doesch and Davor Baric and Igor Rudez and Agita Strelniece and {De Vries}, Erwin and Dave Green and Undine Samuel and Davor Milicic and Istvan Hartyanszky and Michael Berchtold-Herz and Schulze, {P Christian} and Friedrich Mohr and Bruno Meiser and Axel Haverich and Hermann Reichenspurner and Jan Gummert and Guenter Laufer and Andreas Zuckermann",
note = "{\textcopyright} 2018 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT.",
year = "2018",
month = nov,
doi = "10.1111/tri.13289",
language = "English",
volume = "31",
pages = "1223--1232",
journal = "TRANSPL INT",
issn = "0934-0874",
publisher = "Wiley-Blackwell",
number = "11",

}

RIS

TY - JOUR

T1 - Heart re-transplantation in Eurotransplant

AU - Smits, Jacqueline M

AU - De Pauw, Michel

AU - Schulz, Uwe

AU - Van Cleemput, Johan

AU - Raake, Philip

AU - Knezevic, Ivan

AU - Caliskan, Kadir

AU - Sutlic, Zeljko

AU - Knosalla, Christoph

AU - Schoenrath, Felix

AU - Szabolcs, Zoltan

AU - Gottlieb, Jens

AU - Hagl, Christian

AU - Doesch, Andreas

AU - Baric, Davor

AU - Rudez, Igor

AU - Strelniece, Agita

AU - De Vries, Erwin

AU - Green, Dave

AU - Samuel, Undine

AU - Milicic, Davor

AU - Hartyanszky, Istvan

AU - Berchtold-Herz, Michael

AU - Schulze, P Christian

AU - Mohr, Friedrich

AU - Meiser, Bruno

AU - Haverich, Axel

AU - Reichenspurner, Hermann

AU - Gummert, Jan

AU - Laufer, Guenter

AU - Zuckermann, Andreas

N1 - © 2018 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT.

PY - 2018/11

Y1 - 2018/11

N2 - Internationally 3% of the donor hearts are distributed to re-transplant patients. In Eurotransplant, only patients with a primary graft dysfunction (PGD) within 1 week after heart transplantation (HTX) are indicated for high urgency listing. The aim of this study is to provide evidence for the discussion on whether these patients should still be allocated with priority. All consecutive HTX performed in the period 1981-2015 were included. Multivariate Cox' model was built including: donor and recipient age and gender, ischaemia time, recipient diagnose, urgency status and era. The study population included 18 490 HTX, of these 463 (2.6%) were repeat transplants. The major indications for re-HTX were cardiac allograft vasculopathy (CAV) (50%), PGD (26%) and acute rejection (21%). In a multivariate model, compared with first HTX hazards ratio and 95% confidence interval for repeat HTX were 2.27 (1.83-2.82) for PGD, 2.24 (1.76-2.85) for acute rejection and 1.22 (1.00-1.48) for CAV (P < 0.0001). Outcome after cardiac re-HTX strongly depends on the indication for re-HTX with acceptable outcomes for CAV. In contrast, just 47.5% of all hearts transplanted in patients who were re-transplanted for PGD still functioned at 1-month post-transplant. Alternative options like VA-ECMO should be first offered before opting for acute re-transplantation.

AB - Internationally 3% of the donor hearts are distributed to re-transplant patients. In Eurotransplant, only patients with a primary graft dysfunction (PGD) within 1 week after heart transplantation (HTX) are indicated for high urgency listing. The aim of this study is to provide evidence for the discussion on whether these patients should still be allocated with priority. All consecutive HTX performed in the period 1981-2015 were included. Multivariate Cox' model was built including: donor and recipient age and gender, ischaemia time, recipient diagnose, urgency status and era. The study population included 18 490 HTX, of these 463 (2.6%) were repeat transplants. The major indications for re-HTX were cardiac allograft vasculopathy (CAV) (50%), PGD (26%) and acute rejection (21%). In a multivariate model, compared with first HTX hazards ratio and 95% confidence interval for repeat HTX were 2.27 (1.83-2.82) for PGD, 2.24 (1.76-2.85) for acute rejection and 1.22 (1.00-1.48) for CAV (P < 0.0001). Outcome after cardiac re-HTX strongly depends on the indication for re-HTX with acceptable outcomes for CAV. In contrast, just 47.5% of all hearts transplanted in patients who were re-transplanted for PGD still functioned at 1-month post-transplant. Alternative options like VA-ECMO should be first offered before opting for acute re-transplantation.

KW - Adult

KW - Europe

KW - Female

KW - Graft Rejection/epidemiology

KW - Heart Diseases/surgery

KW - Heart Failure/surgery

KW - Heart Transplantation/statistics & numerical data

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Primary Graft Dysfunction/epidemiology

KW - Proportional Hazards Models

KW - Reoperation/statistics & numerical data

KW - Retrospective Studies

KW - Time Factors

KW - Tissue Donors

KW - Young Adult

U2 - 10.1111/tri.13289

DO - 10.1111/tri.13289

M3 - SCORING: Journal article

C2 - 29885002

VL - 31

SP - 1223

EP - 1232

JO - TRANSPL INT

JF - TRANSPL INT

SN - 0934-0874

IS - 11

ER -