Gold vs. platinum-iridium tip catheter for cavotricuspid isthmus ablation: the AURUM 8 study

TY - JOUR

T1 - Gold vs. platinum-iridium tip catheter for cavotricuspid isthmus ablation: the AURUM 8 study

AU - Lewalter, Thorsten

AU - Weiss, Christian

AU - Spencker, Sebastian

AU - Jung, Werner

AU - Haverkamp, Wilhelm

AU - Willems, Stephan

AU - Deneke, Thomas

AU - Kautzner, Josef

AU - Wiedemann, Michael

AU - Siebels, Jürgen

AU - Pitschner, Heinz Friedrich

AU - Hoffmann, Ellen

AU - Hindricks, Gerd

AU - Zabel, Markus

AU - Vester, Ernst

AU - Schwacke, Harald

AU - Mittmann-Braun, Erica

AU - Lickfett, Lars

AU - Hoffmeister, Sabine

AU - Proff, Jochen

AU - Mewis, Christian

AU - Bauer, Wolfgang

AU - AURUM 8 Study Investigators

PY - 2011/1

Y1 - 2011/1

N2 - AIMS: Gold electrodes have the theoretical advantage of creating bigger lesions than platinum-iridium (Pt-Ir) electrodes. We performed a prospective randomized study to compare the clinical efficacy of standard 8 mm Pt-Ir tip catheter (control) and 8 mm gold-tip catheters in the ablation of the cavotricuspid isthmus (CTI)-dependent atrial flutter.METHODS AND RESULTS: A total of 463 patients undergoing CTI ablation in 19 clinical centres were randomized to receive the treatment by gold-tip or control catheter. The primary endpoint was cumulative radiofrequency (RF) application duration until achieving bidirectional CTI block. It did not differ significantly for the two catheters. The gold-tip catheter was, however, associated with a higher ablation success rate (94.3 vs. 89.0%, P = 0.042) and a substantially lower incidence of char and coagulum formation (4.8 vs. 37.9%, P < 0.001), which required exchange of 1 gold-tip (0.4%) and 10 control catheters (4.6%, P = 0.005). The gold-tip catheter delivered more mean power (52 ± 12 W) than the control catheter (48 ± 13 W, P < 0.001). Both mean and maximum temperatures measured by the thermocouple integrated in the catheter tip were statistically significantly lower in the gold (mean: 53.2 ± 4.7°C, max: 68.7 ± 6.6°C) than in the control catheter (54.3 ± 5.2 and 70.2 ± 7.0°C, respectively, P < 0.05). Fluoroscopy time, procedure duration, procedural-related complications, and arrhythmia recurrence during 6 months of follow-up did not differ between the two catheters.CONCLUSION: Owing to a higher primary ablation success rate and reduced incidence of char/coagulum formation, gold may be preferred over Pt-Ir as electrode material for 8 mm tip catheters for CTI ablation. ClinicalTrials.gov: NCT00326001 (http://clinicaltrials.gov/ct2/show/NCT00326001).

AB - AIMS: Gold electrodes have the theoretical advantage of creating bigger lesions than platinum-iridium (Pt-Ir) electrodes. We performed a prospective randomized study to compare the clinical efficacy of standard 8 mm Pt-Ir tip catheter (control) and 8 mm gold-tip catheters in the ablation of the cavotricuspid isthmus (CTI)-dependent atrial flutter.METHODS AND RESULTS: A total of 463 patients undergoing CTI ablation in 19 clinical centres were randomized to receive the treatment by gold-tip or control catheter. The primary endpoint was cumulative radiofrequency (RF) application duration until achieving bidirectional CTI block. It did not differ significantly for the two catheters. The gold-tip catheter was, however, associated with a higher ablation success rate (94.3 vs. 89.0%, P = 0.042) and a substantially lower incidence of char and coagulum formation (4.8 vs. 37.9%, P < 0.001), which required exchange of 1 gold-tip (0.4%) and 10 control catheters (4.6%, P = 0.005). The gold-tip catheter delivered more mean power (52 ± 12 W) than the control catheter (48 ± 13 W, P < 0.001). Both mean and maximum temperatures measured by the thermocouple integrated in the catheter tip were statistically significantly lower in the gold (mean: 53.2 ± 4.7°C, max: 68.7 ± 6.6°C) than in the control catheter (54.3 ± 5.2 and 70.2 ± 7.0°C, respectively, P < 0.05). Fluoroscopy time, procedure duration, procedural-related complications, and arrhythmia recurrence during 6 months of follow-up did not differ between the two catheters.CONCLUSION: Owing to a higher primary ablation success rate and reduced incidence of char/coagulum formation, gold may be preferred over Pt-Ir as electrode material for 8 mm tip catheters for CTI ablation. ClinicalTrials.gov: NCT00326001 (http://clinicaltrials.gov/ct2/show/NCT00326001).

KW - Aged

KW - Atrial Flutter/surgery

KW - Catheter Ablation/instrumentation

KW - Electrodes

KW - Female

KW - Follow-Up Studies

KW - Gold

KW - Humans

KW - Iridium

KW - Male

KW - Middle Aged

KW - Platinum

KW - Prospective Studies

KW - Recurrence

KW - Retrospective Studies

KW - Thermal Conductivity

KW - Treatment Outcome

U2 - 10.1093/europace/euq339

DO - 10.1093/europace/euq339

M3 - SCORING: Journal article

C2 - 20876601

VL - 13

SP - 102

EP - 108

JO - EUROPACE

JF - EUROPACE

SN - 1099-5129

IS - 1

ER -