Research ExplorerPublicationsGeniculocortical input drives genetic distinctions between p...

Geniculocortical input drives genetic distinctions between primary and higher-order visual areas

Standard

Geniculocortical input drives genetic distinctions between primary and higher-order visual areas. / Chou, Shen-Ju; Babot, Zoila; Leingärtner, Axel; Studer, Michele; Nakagawa, Yasushi; O'Leary, Dennis D M.

In: SCIENCE, Vol. 340, No. 6137, 07.06.2013, p. 1239-42.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chou, S-J, Babot, Z, Leingärtner, A, Studer, M, Nakagawa, Y & O'Leary, DDM 2013, 'Geniculocortical input drives genetic distinctions between primary and higher-order visual areas', SCIENCE, vol. 340, no. 6137, pp. 1239-42. https://doi.org/10.1126/science.1232806

APA

Chou, S-J., Babot, Z., Leingärtner, A., Studer, M., Nakagawa, Y., & O'Leary, D. D. M. (2013). Geniculocortical input drives genetic distinctions between primary and higher-order visual areas. SCIENCE, 340(6137), 1239-42. https://doi.org/10.1126/science.1232806

Vancouver

Chou S-J, Babot Z, Leingärtner A, Studer M, Nakagawa Y, O'Leary DDM. Geniculocortical input drives genetic distinctions between primary and higher-order visual areas. SCIENCE. 2013 Jun 7;340(6137):1239-42. https://doi.org/10.1126/science.1232806

Bibtex

@article{ff9543166cc24b2b8016fb1394019fb7,
title = "Geniculocortical input drives genetic distinctions between primary and higher-order visual areas",
abstract = "Studies of area patterning of the neocortex have focused on primary areas, concluding that the primary visual area, V1, is specified by transcription factors (TFs) expressed by progenitors. Mechanisms that determine higher-order visual areas (V(HO)) and distinguish them from V1 are unknown. We demonstrated a requirement for thalamocortical axon (TCA) input by genetically deleting geniculocortical TCAs and showed that they drive differentiation of patterned gene expression that distinguishes V1 and V(HO). Our findings suggest a multistage process for area patterning: TFs expressed by progenitors specify an occipital visual cortical field that differentiates into V1 and V(HO); this latter phase requires geniculocortical TCA input to the nascent V1 that determines genetic distinctions between V1 and V(HO) for all layers and ultimately determines their area-specific functional properties.",
keywords = "Animals, Axons, Gene Deletion, Gene Expression Regulation, Genetic Markers, Mice, Mice, Knockout, Neocortex, Neural Stem Cells, Thalamus, Transcription Factors, Visual Cortex, Visual Fields",
author = "Shen-Ju Chou and Zoila Babot and Axel Leing{\"a}rtner and Michele Studer and Yasushi Nakagawa and O'Leary, {Dennis D M}",
year = "2013",
month = jun,
day = "7",
doi = "10.1126/science.1232806",
language = "English",
volume = "340",
pages = "1239--42",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6137",

}

RIS

TY - JOUR

T1 - Geniculocortical input drives genetic distinctions between primary and higher-order visual areas

AU - Chou, Shen-Ju

AU - Babot, Zoila

AU - Leingärtner, Axel

AU - Studer, Michele

AU - Nakagawa, Yasushi

AU - O'Leary, Dennis D M

PY - 2013/6/7

Y1 - 2013/6/7

N2 - Studies of area patterning of the neocortex have focused on primary areas, concluding that the primary visual area, V1, is specified by transcription factors (TFs) expressed by progenitors. Mechanisms that determine higher-order visual areas (V(HO)) and distinguish them from V1 are unknown. We demonstrated a requirement for thalamocortical axon (TCA) input by genetically deleting geniculocortical TCAs and showed that they drive differentiation of patterned gene expression that distinguishes V1 and V(HO). Our findings suggest a multistage process for area patterning: TFs expressed by progenitors specify an occipital visual cortical field that differentiates into V1 and V(HO); this latter phase requires geniculocortical TCA input to the nascent V1 that determines genetic distinctions between V1 and V(HO) for all layers and ultimately determines their area-specific functional properties.

AB - Studies of area patterning of the neocortex have focused on primary areas, concluding that the primary visual area, V1, is specified by transcription factors (TFs) expressed by progenitors. Mechanisms that determine higher-order visual areas (V(HO)) and distinguish them from V1 are unknown. We demonstrated a requirement for thalamocortical axon (TCA) input by genetically deleting geniculocortical TCAs and showed that they drive differentiation of patterned gene expression that distinguishes V1 and V(HO). Our findings suggest a multistage process for area patterning: TFs expressed by progenitors specify an occipital visual cortical field that differentiates into V1 and V(HO); this latter phase requires geniculocortical TCA input to the nascent V1 that determines genetic distinctions between V1 and V(HO) for all layers and ultimately determines their area-specific functional properties.

KW - Animals

KW - Axons

KW - Gene Deletion

KW - Gene Expression Regulation

KW - Genetic Markers

KW - Mice

KW - Mice, Knockout

KW - Neocortex

KW - Neural Stem Cells

KW - Thalamus

KW - Transcription Factors

KW - Visual Cortex

KW - Visual Fields

U2 - 10.1126/science.1232806

DO - 10.1126/science.1232806

M3 - SCORING: Journal article

C2 - 23744949

VL - 340

SP - 1239

EP - 1242

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6137

ER -