Gender differences in first episode psychotic mania
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Gender differences in first episode psychotic mania. / Cotton, Sue M; Lambert, Martin; Berk, Michael; Schimmelmann, Benno G; Butselaar, Felicity J; McGorry, Patrick D; Conus, Philippe.
In: BMC PSYCHIATRY, Vol. 13, 01.01.2013, p. 82.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Gender differences in first episode psychotic mania
AU - Cotton, Sue M
AU - Lambert, Martin
AU - Berk, Michael
AU - Schimmelmann, Benno G
AU - Butselaar, Felicity J
AU - McGorry, Patrick D
AU - Conus, Philippe
PY - 2013/1/1
Y1 - 2013/1/1
N2 - BACKGROUND: The aim of this paper was to delineate the impact of gender on premorbid history, onset, and 18 month outcomes of first episode psychotic mania (FEPM) patients.METHODS: Medical file audit assessment of 118 (male = 71; female = 47) patients with FEPM aged 15 to 29 years was undertaken on clinical and functional measures.RESULTS: Males with FEPM had increased likelihood of substance use (OR = 13.41, p <.001) and forensic issues (OR = 4.71, p = .008), whereas females were more likely to have history of sexual abuse trauma (OR = 7.12, p = .001). At service entry, males were more likely to be using substances, especially cannabis (OR = 2.15, p = .047), had more severe illness (OR = 1.72, p = .037), and poorer functioning (OR = 0.96, p = .045). During treatment males were more likely to decrease substance use (OR = 5.34, p = .008) and were more likely to be living with family (OR = 4.30, p = .009). There were no gender differences in age of onset, psychopathology or functioning at discharge.CONCLUSIONS: Clinically meaningful gender differences in FEPM were driven by risk factors possibly associated with poor outcome. For males, substance use might be associated with poorer clinical presentation and functioning. In females with FEPM, the impact of sexual trauma on illness course warrants further consideration.
AB - BACKGROUND: The aim of this paper was to delineate the impact of gender on premorbid history, onset, and 18 month outcomes of first episode psychotic mania (FEPM) patients.METHODS: Medical file audit assessment of 118 (male = 71; female = 47) patients with FEPM aged 15 to 29 years was undertaken on clinical and functional measures.RESULTS: Males with FEPM had increased likelihood of substance use (OR = 13.41, p <.001) and forensic issues (OR = 4.71, p = .008), whereas females were more likely to have history of sexual abuse trauma (OR = 7.12, p = .001). At service entry, males were more likely to be using substances, especially cannabis (OR = 2.15, p = .047), had more severe illness (OR = 1.72, p = .037), and poorer functioning (OR = 0.96, p = .045). During treatment males were more likely to decrease substance use (OR = 5.34, p = .008) and were more likely to be living with family (OR = 4.30, p = .009). There were no gender differences in age of onset, psychopathology or functioning at discharge.CONCLUSIONS: Clinically meaningful gender differences in FEPM were driven by risk factors possibly associated with poor outcome. For males, substance use might be associated with poorer clinical presentation and functioning. In females with FEPM, the impact of sexual trauma on illness course warrants further consideration.
KW - Adolescent
KW - Adult
KW - Age of Onset
KW - Bipolar Disorder
KW - Female
KW - Humans
KW - Logistic Models
KW - Male
KW - Risk Factors
KW - Sex Factors
KW - Sex Offenses
KW - Substance-Related Disorders
KW - Young Adult
U2 - 10.1186/1471-244X-13-82
DO - 10.1186/1471-244X-13-82
M3 - SCORING: Journal article
C2 - 23497439
VL - 13
SP - 82
JO - BMC PSYCHIATRY
JF - BMC PSYCHIATRY
SN - 1471-244X
ER -
