Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.
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Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. / Beesley, Jonathan; Pickett, Hilda A; Johnatty, Sharon E; Dunning, Alison M; Chen, Xiaoqing; Li, Jun; Michailidou, Kyriaki; Lu, Yi; Rider, David N; Palmieri, Rachel T; Stutz, Michael D; Lambrechts, Diether; Despierre, Evelyn; Lambrechts, Sandrina; Vergote, Ignace; Chang-Claude, Jenny; Nickels, Stefan; Vrieling, Alina; Flesch-Janys, Dieter; Wang-Gohrke, Shan; Eilber, Ursula; Bogdanova, Natalia; Antonenkova, Natalia; Runnebaum, Ingo B; Dörk, Thilo; Goodman, Marc T; Lurie, Galina; Wilkens, Lynne R; Matsuno, Rayna K; Kiemeney, Lambertus A; Aben, Katja K H; Marees, Tamara; Massuger, Leon F A G; Fridley, Brooke L; Vierkant, Robert A; Bandera, Elisa V; Olson, Sara H; Orlow, Irene; Rodriguez-Rodriguez, Lorna; Cook, Linda S; Le, Nhu D; Brooks-Wilson, Angela; Kelemen, Linda E; Campbell, Ian; Gayther, Simon A; Ramus, Susan J; Gentry-Maharaj, Aleksandra; Menon, Usha; Ahmed, Shahana; Baynes, Caroline; Pharoah, Paul D; Group, Australian Ovarian Cancer Study; Investigators, ABCTB; Muir, Kenneth; Lophatananon, Artitaya; Chaiwerawattana, Arkom; Wiangnon, Surapon; Macgregor, Stuart; Easton, Douglas F; Reddel, Roger R; Goode, Ellen L; Chenevix-Trench, Georgia; Consortium, Ovarian Cancer Association.
In: PLOS ONE, Vol. 6, No. 9, 9, 2011, p. 24987.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.
AU - Beesley, Jonathan
AU - Pickett, Hilda A
AU - Johnatty, Sharon E
AU - Dunning, Alison M
AU - Chen, Xiaoqing
AU - Li, Jun
AU - Michailidou, Kyriaki
AU - Lu, Yi
AU - Rider, David N
AU - Palmieri, Rachel T
AU - Stutz, Michael D
AU - Lambrechts, Diether
AU - Despierre, Evelyn
AU - Lambrechts, Sandrina
AU - Vergote, Ignace
AU - Chang-Claude, Jenny
AU - Nickels, Stefan
AU - Vrieling, Alina
AU - Flesch-Janys, Dieter
AU - Wang-Gohrke, Shan
AU - Eilber, Ursula
AU - Bogdanova, Natalia
AU - Antonenkova, Natalia
AU - Runnebaum, Ingo B
AU - Dörk, Thilo
AU - Goodman, Marc T
AU - Lurie, Galina
AU - Wilkens, Lynne R
AU - Matsuno, Rayna K
AU - Kiemeney, Lambertus A
AU - Aben, Katja K H
AU - Marees, Tamara
AU - Massuger, Leon F A G
AU - Fridley, Brooke L
AU - Vierkant, Robert A
AU - Bandera, Elisa V
AU - Olson, Sara H
AU - Orlow, Irene
AU - Rodriguez-Rodriguez, Lorna
AU - Cook, Linda S
AU - Le, Nhu D
AU - Brooks-Wilson, Angela
AU - Kelemen, Linda E
AU - Campbell, Ian
AU - Gayther, Simon A
AU - Ramus, Susan J
AU - Gentry-Maharaj, Aleksandra
AU - Menon, Usha
AU - Ahmed, Shahana
AU - Baynes, Caroline
AU - Pharoah, Paul D
AU - Group, Australian Ovarian Cancer Study
AU - Investigators, ABCTB
AU - Muir, Kenneth
AU - Lophatananon, Artitaya
AU - Chaiwerawattana, Arkom
AU - Wiangnon, Surapon
AU - Macgregor, Stuart
AU - Easton, Douglas F
AU - Reddel, Roger R
AU - Goode, Ellen L
AU - Chenevix-Trench, Georgia
AU - Consortium, Ovarian Cancer Association
PY - 2011
Y1 - 2011
N2 - Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the TERT promoter. We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity.
AB - Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the TERT promoter. We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity.
KW - Humans
KW - Female
KW - Prognosis
KW - Case-Control Studies
KW - Breast Neoplasms/genetics
KW - Polymorphism, Single Nucleotide/genetics
KW - Telomerase/genetics
KW - Cystadenocarcinoma, Serous/genetics
KW - Neoplasms, Glandular and Epithelial/genetics
KW - Ovarian Neoplasms/genetics
KW - Humans
KW - Female
KW - Prognosis
KW - Case-Control Studies
KW - Breast Neoplasms/genetics
KW - Polymorphism, Single Nucleotide/genetics
KW - Telomerase/genetics
KW - Cystadenocarcinoma, Serous/genetics
KW - Neoplasms, Glandular and Epithelial/genetics
KW - Ovarian Neoplasms/genetics
M3 - SCORING: Journal article
VL - 6
SP - 24987
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 9
M1 - 9
ER -