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Extracorporeal lung support in H1N1 provoked acute respiratory failure: the experience of the German ARDS Network

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Extracorporeal lung support in H1N1 provoked acute respiratory failure: the experience of the German ARDS Network. / Weber-Carstens, Steffen; Goldmann, Anton; Quintel, Michael; Kalenka, Armin; Kluge, Stefan; Peters, Jürgen; Putensen, Christian; Müller, Thomas; Rosseau, Simone; Zwißler, Bernhard; Moerer, Onnen.

In: DTSCH ARZTEBL INT, Vol. 110, No. 33-34, 01.08.2013, p. 543-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Weber-Carstens, S, Goldmann, A, Quintel, M, Kalenka, A, Kluge, S, Peters, J, Putensen, C, Müller, T, Rosseau, S, Zwißler, B & Moerer, O 2013, 'Extracorporeal lung support in H1N1 provoked acute respiratory failure: the experience of the German ARDS Network', DTSCH ARZTEBL INT, vol. 110, no. 33-34, pp. 543-9. https://doi.org/10.3238/arztebl.2013.0543

APA

Weber-Carstens, S., Goldmann, A., Quintel, M., Kalenka, A., Kluge, S., Peters, J., Putensen, C., Müller, T., Rosseau, S., Zwißler, B., & Moerer, O. (2013). Extracorporeal lung support in H1N1 provoked acute respiratory failure: the experience of the German ARDS Network. DTSCH ARZTEBL INT, 110(33-34), 543-9. https://doi.org/10.3238/arztebl.2013.0543

Vancouver

Weber-Carstens S, Goldmann A, Quintel M, Kalenka A, Kluge S, Peters J et al. Extracorporeal lung support in H1N1 provoked acute respiratory failure: the experience of the German ARDS Network. DTSCH ARZTEBL INT. 2013 Aug 1;110(33-34):543-9. https://doi.org/10.3238/arztebl.2013.0543

Bibtex

@article{1a5542e6c3284ddb8168750e0adfd8ec,
title = "Extracorporeal lung support in H1N1 provoked acute respiratory failure: the experience of the German ARDS Network",
abstract = "BACKGROUND: During the H1N1 pandemic of 2009 and 2010, the large number of patients with severe respiratory failure due to H1N1 infection strained the capacities of treatment facilities for extracorporeal membrane oxygenation (ECMO) around the world. No data on this topic have yet been published for Germany.METHODS: During the pandemic, the German ARDS Network (a task force of the DIVI's respiratory failure section) kept track of the availability of ECMO treatment facilities with a day-to-day, Internet-based capacity assessment. In cooperation with the Robert Koch Institute, epidemiological and clinical data were obtained on all patients treated for influenza in intensive care units.RESULTS: 116 patients were identified who had H1N1 disease and were treated in the intensive care units of 9 university hospitals and 3 other maximum medical care hospitals. 61 of them received ECMO. The overall mortality was 38% (44 of 116 patients); among patients receiving ECMO, the mortality was 54% (33 of 61 patients). The mortality was higher among patients who had an accompanying malignancy or immune deficiency (72.2%).CONCLUSION: Even persons without any other accompanying disease developed life-threatening respiratory failure as a result of H1N1 infection, and many of these patients needed ECMO. This study reveals for the first time that the mortality of H1N1 infection in Germany is comparable to that in other countries. H1N1 patients with acute respiratory failure had a worse outcome if they also had serious accompanying diseases.",
keywords = "Acute Disease, Adult, Age Distribution, Causality, Community Networks, Comorbidity, Extracorporeal Membrane Oxygenation, Female, Germany, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Male, Middle Aged, Pandemics, Prevalence, Respiratory Distress Syndrome, Adult, Retrospective Studies, Risk Factors, Sex Distribution, Survival Rate, Treatment Outcome",
author = "Steffen Weber-Carstens and Anton Goldmann and Michael Quintel and Armin Kalenka and Stefan Kluge and J{\"u}rgen Peters and Christian Putensen and Thomas M{\"u}ller and Simone Rosseau and Bernhard Zwi{\ss}ler and Onnen Moerer",
year = "2013",
month = aug,
day = "1",
doi = "10.3238/arztebl.2013.0543",
language = "English",
volume = "110",
pages = "543--9",
journal = "DTSCH ARZTEBL INT",
issn = "1866-0452",
publisher = "Deutscher Arzte-Verlag",
number = "33-34",

}

RIS

TY - JOUR

T1 - Extracorporeal lung support in H1N1 provoked acute respiratory failure: the experience of the German ARDS Network

AU - Weber-Carstens, Steffen

AU - Goldmann, Anton

AU - Quintel, Michael

AU - Kalenka, Armin

AU - Kluge, Stefan

AU - Peters, Jürgen

AU - Putensen, Christian

AU - Müller, Thomas

AU - Rosseau, Simone

AU - Zwißler, Bernhard

AU - Moerer, Onnen

PY - 2013/8/1

Y1 - 2013/8/1

N2 - BACKGROUND: During the H1N1 pandemic of 2009 and 2010, the large number of patients with severe respiratory failure due to H1N1 infection strained the capacities of treatment facilities for extracorporeal membrane oxygenation (ECMO) around the world. No data on this topic have yet been published for Germany.METHODS: During the pandemic, the German ARDS Network (a task force of the DIVI's respiratory failure section) kept track of the availability of ECMO treatment facilities with a day-to-day, Internet-based capacity assessment. In cooperation with the Robert Koch Institute, epidemiological and clinical data were obtained on all patients treated for influenza in intensive care units.RESULTS: 116 patients were identified who had H1N1 disease and were treated in the intensive care units of 9 university hospitals and 3 other maximum medical care hospitals. 61 of them received ECMO. The overall mortality was 38% (44 of 116 patients); among patients receiving ECMO, the mortality was 54% (33 of 61 patients). The mortality was higher among patients who had an accompanying malignancy or immune deficiency (72.2%).CONCLUSION: Even persons without any other accompanying disease developed life-threatening respiratory failure as a result of H1N1 infection, and many of these patients needed ECMO. This study reveals for the first time that the mortality of H1N1 infection in Germany is comparable to that in other countries. H1N1 patients with acute respiratory failure had a worse outcome if they also had serious accompanying diseases.

AB - BACKGROUND: During the H1N1 pandemic of 2009 and 2010, the large number of patients with severe respiratory failure due to H1N1 infection strained the capacities of treatment facilities for extracorporeal membrane oxygenation (ECMO) around the world. No data on this topic have yet been published for Germany.METHODS: During the pandemic, the German ARDS Network (a task force of the DIVI's respiratory failure section) kept track of the availability of ECMO treatment facilities with a day-to-day, Internet-based capacity assessment. In cooperation with the Robert Koch Institute, epidemiological and clinical data were obtained on all patients treated for influenza in intensive care units.RESULTS: 116 patients were identified who had H1N1 disease and were treated in the intensive care units of 9 university hospitals and 3 other maximum medical care hospitals. 61 of them received ECMO. The overall mortality was 38% (44 of 116 patients); among patients receiving ECMO, the mortality was 54% (33 of 61 patients). The mortality was higher among patients who had an accompanying malignancy or immune deficiency (72.2%).CONCLUSION: Even persons without any other accompanying disease developed life-threatening respiratory failure as a result of H1N1 infection, and many of these patients needed ECMO. This study reveals for the first time that the mortality of H1N1 infection in Germany is comparable to that in other countries. H1N1 patients with acute respiratory failure had a worse outcome if they also had serious accompanying diseases.

KW - Acute Disease

KW - Adult

KW - Age Distribution

KW - Causality

KW - Community Networks

KW - Comorbidity

KW - Extracorporeal Membrane Oxygenation

KW - Female

KW - Germany

KW - Humans

KW - Influenza A Virus, H1N1 Subtype

KW - Influenza, Human

KW - Male

KW - Middle Aged

KW - Pandemics

KW - Prevalence

KW - Respiratory Distress Syndrome, Adult

KW - Retrospective Studies

KW - Risk Factors

KW - Sex Distribution

KW - Survival Rate

KW - Treatment Outcome

U2 - 10.3238/arztebl.2013.0543

DO - 10.3238/arztebl.2013.0543

M3 - SCORING: Journal article

C2 - 24069078

VL - 110

SP - 543

EP - 549

JO - DTSCH ARZTEBL INT

JF - DTSCH ARZTEBL INT

SN - 1866-0452

IS - 33-34

ER -