Efficacy of the Managing Cancer and Living Meaningfully (CALM) individual psychotherapy for patients with advanced cancer
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Efficacy of the Managing Cancer and Living Meaningfully (CALM) individual psychotherapy for patients with advanced cancer : A single-blind randomized controlled trial. / Mehnert, Anja; Koranyi, Susan; Philipp, Rebecca; Scheffold, Katharina; Kriston, Levente; Lehmann-Laue, Antje; Engelmann, Dorit; Vehling, Sigrun; Eisenecker, Christina; Oechsle, Karin; Schulz-Kindermann, Frank; Rodin, Gary; Härter, Martin.
In: PSYCHO-ONCOLOGY, Vol. 29, No. 11, 11.2020, p. 1895-1904.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Efficacy of the Managing Cancer and Living Meaningfully (CALM) individual psychotherapy for patients with advanced cancer
T2 - A single-blind randomized controlled trial
AU - Mehnert, Anja
AU - Koranyi, Susan
AU - Philipp, Rebecca
AU - Scheffold, Katharina
AU - Kriston, Levente
AU - Lehmann-Laue, Antje
AU - Engelmann, Dorit
AU - Vehling, Sigrun
AU - Eisenecker, Christina
AU - Oechsle, Karin
AU - Schulz-Kindermann, Frank
AU - Rodin, Gary
AU - Härter, Martin
N1 - © 2020 John Wiley & Sons Ltd.
PY - 2020/11
Y1 - 2020/11
N2 - OBJECTIVE: We aimed to determine whether the Managing Cancer and Living Meaningfully (CALM) therapy is superior to a non-manualized supportive psycho-oncological counselling intervention (SPI).METHODS: Adult patients with advanced cancer and ≥9 points on the PHQ-9 and/or ≥5 points on the DT were randomized to CALM or SPI. We hypothesized that CALM patients would report significantly less depression (primary outcome) on the BDI-II and the PHQ-9 6 months after baseline compared to SPI patients.RESULTS: From 329 eligible patients, 206 participated (61.2% female; age: M = 57.9 [SD = 11.7]; 84.5% UICC IV stage). Of them, 99 were assigned to CALM and 107 to SPI. Intention-to-treat analyses revealed significantly less depressive symptoms at 6 months than at baseline (P < .001 for BDI-II and PHQ-9), but participants in the CALM and SPI group did not differ in depression severity (BDI-II: P = .62, PHQ-9: P = .998). Group differences on secondary outcomes were statistically not significant either.CONCLUSIONS: CALM therapy was associated with reduction in depressive symptoms over time but this improvement was not statistically significant different than that obtained within SPI group.
AB - OBJECTIVE: We aimed to determine whether the Managing Cancer and Living Meaningfully (CALM) therapy is superior to a non-manualized supportive psycho-oncological counselling intervention (SPI).METHODS: Adult patients with advanced cancer and ≥9 points on the PHQ-9 and/or ≥5 points on the DT were randomized to CALM or SPI. We hypothesized that CALM patients would report significantly less depression (primary outcome) on the BDI-II and the PHQ-9 6 months after baseline compared to SPI patients.RESULTS: From 329 eligible patients, 206 participated (61.2% female; age: M = 57.9 [SD = 11.7]; 84.5% UICC IV stage). Of them, 99 were assigned to CALM and 107 to SPI. Intention-to-treat analyses revealed significantly less depressive symptoms at 6 months than at baseline (P < .001 for BDI-II and PHQ-9), but participants in the CALM and SPI group did not differ in depression severity (BDI-II: P = .62, PHQ-9: P = .998). Group differences on secondary outcomes were statistically not significant either.CONCLUSIONS: CALM therapy was associated with reduction in depressive symptoms over time but this improvement was not statistically significant different than that obtained within SPI group.
U2 - 10.1002/pon.5521
DO - 10.1002/pon.5521
M3 - SCORING: Journal article
C2 - 32803815
VL - 29
SP - 1895
EP - 1904
JO - PSYCHO-ONCOLOGY
JF - PSYCHO-ONCOLOGY
SN - 1057-9249
IS - 11
ER -
