Research ExplorerPublicationsEffect of Systemic Antioxidant Allopurinol Therapy on Skin F...

Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival

Standard

Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival. / Rasti Ardakani, Mehdi; Al-Dam, Ahmed; Rashad, Ashkan; Shayesteh Moghadam, Ali.

In: WORLD J PLAST SURG, Vol. 6, No. 1, 01.2017, p. 54-61.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rasti Ardakani, M, Al-Dam, A, Rashad, A & Shayesteh Moghadam, A 2017, 'Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival', WORLD J PLAST SURG, vol. 6, no. 1, pp. 54-61.

APA

Rasti Ardakani, M., Al-Dam, A., Rashad, A., & Shayesteh Moghadam, A. (2017). Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival. WORLD J PLAST SURG, 6(1), 54-61.

Vancouver

Rasti Ardakani M, Al-Dam A, Rashad A, Shayesteh Moghadam A. Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival. WORLD J PLAST SURG. 2017 Jan;6(1):54-61.

Bibtex

@article{433b8ae6728842bcb1706419744b7d9f,
title = "Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival",
abstract = "BACKGROUND: It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs.METHODS: Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation.RESULTS: Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (p<0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps.CONCLUSION: It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.",
keywords = "Journal Article",
author = "{Rasti Ardakani}, Mehdi and Ahmed Al-Dam and Ashkan Rashad and {Shayesteh Moghadam}, Ali",
year = "2017",
month = jan,
language = "English",
volume = "6",
pages = "54--61",
journal = "WORLD J PLAST SURG",
issn = "2228-7914",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival

AU - Rasti Ardakani, Mehdi

AU - Al-Dam, Ahmed

AU - Rashad, Ashkan

AU - Shayesteh Moghadam, Ali

PY - 2017/1

Y1 - 2017/1

N2 - BACKGROUND: It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs.METHODS: Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation.RESULTS: Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (p<0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps.CONCLUSION: It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.

AB - BACKGROUND: It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs.METHODS: Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation.RESULTS: Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (p<0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps.CONCLUSION: It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.

KW - Journal Article

M3 - SCORING: Journal article

C2 - 28289614

VL - 6

SP - 54

EP - 61

JO - WORLD J PLAST SURG

JF - WORLD J PLAST SURG

SN - 2228-7914

IS - 1

ER -