Effect of smoking on macular function and retinal structure in retinitis pigmentosa
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Effect of smoking on macular function and retinal structure in retinitis pigmentosa. / Oishi, Akio; Noda, Kazunori; Birtel, Johannes; Miyake, Masahiro; Sato, Atsuyasu; Hasegawa, Tomoko; Miyata, Manabu; Numa, Shogo; Charbel Issa, Peter; Tsujikawa, Akitaka.
In: BRAIN COMMUN, Vol. 2, No. 2, 2020, p. fcaa117.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of smoking on macular function and retinal structure in retinitis pigmentosa
AU - Oishi, Akio
AU - Noda, Kazunori
AU - Birtel, Johannes
AU - Miyake, Masahiro
AU - Sato, Atsuyasu
AU - Hasegawa, Tomoko
AU - Miyata, Manabu
AU - Numa, Shogo
AU - Charbel Issa, Peter
AU - Tsujikawa, Akitaka
N1 - © The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.
PY - 2020
Y1 - 2020
N2 - Retinitis pigmentosa is an inherited neurodegenerative disease of the retina. We investigated smoking as a modifiable environmental factor for the progression of this currently untreatable disease. Clinical data, smoking history, macular function and morphology including visual acuity, visual field sensitivity, ellipsoid zone width and central retinal thickness were investigated. Association between pack × years and these parameters were evaluated using generalized estimating equation models to adjust confounding factors such as age and sex. A total of 410 patients with retinitis pigmentosa (≥20 years old; 209 female) were included, 164 had a smoking history. Patients without smoking history revealed a better visual acuity than smokers (0.39 versus 0.57, P = 0.001). The pack × years index was associated with worse visual acuity and thinner central retinal thickness after adjusting for age and sex (P = 0.0047 and 0.0099, respectively). Visual field and ellipsoid zone width showed a non-significant decline with increasing pack × years. This study indicates an association of smoking with worse macular function and structural integrity in retinitis pigmentosa patients, and hence a potential detrimental effect of smoking on the disease course.
AB - Retinitis pigmentosa is an inherited neurodegenerative disease of the retina. We investigated smoking as a modifiable environmental factor for the progression of this currently untreatable disease. Clinical data, smoking history, macular function and morphology including visual acuity, visual field sensitivity, ellipsoid zone width and central retinal thickness were investigated. Association between pack × years and these parameters were evaluated using generalized estimating equation models to adjust confounding factors such as age and sex. A total of 410 patients with retinitis pigmentosa (≥20 years old; 209 female) were included, 164 had a smoking history. Patients without smoking history revealed a better visual acuity than smokers (0.39 versus 0.57, P = 0.001). The pack × years index was associated with worse visual acuity and thinner central retinal thickness after adjusting for age and sex (P = 0.0047 and 0.0099, respectively). Visual field and ellipsoid zone width showed a non-significant decline with increasing pack × years. This study indicates an association of smoking with worse macular function and structural integrity in retinitis pigmentosa patients, and hence a potential detrimental effect of smoking on the disease course.
U2 - 10.1093/braincomms/fcaa117
DO - 10.1093/braincomms/fcaa117
M3 - SCORING: Journal article
C2 - 33134916
VL - 2
SP - fcaa117
JO - BRAIN COMMUN
JF - BRAIN COMMUN
SN - 2632-1297
IS - 2
ER -
