Effect of sensory stimulation in rat barrel cortex, dorsolateral striatum and on corticostriatal functional connectivity.
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Effect of sensory stimulation in rat barrel cortex, dorsolateral striatum and on corticostriatal functional connectivity. / Syed, Emilie; Sharott, Andrew; Moll, Christian; Engel, Andreas K.; Král, Andrej.
In: EUR J NEUROSCI, Vol. 33, No. 3, 3, 2011, p. 461-470.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of sensory stimulation in rat barrel cortex, dorsolateral striatum and on corticostriatal functional connectivity.
AU - Syed, Emilie
AU - Sharott, Andrew
AU - Moll, Christian
AU - Engel, Andreas K.
AU - Král, Andrej
PY - 2011
Y1 - 2011
N2 - The striatum integrates sensory information to enable action selection and behavioural reinforcement. In the rat, a large topographical projection from the rat barrel cortex to widely distributed areas of the striatum is assumed to be an important structural component supporting these processes. The striatal sensory response is, however, not comprehensively understood at a network level. We used a 10-Hz, 100-ms air puff, allowing undamped movement of multiple whiskers, to look at functional connectivity in contralateral cortex and striatum in response to sensory stimulation. Simultaneous recordings of cortical and striatal local field potentials (LFPs) were made under isoflurane anaesthesia in 15 male Brown Norway rats. Four electrodes were placed in the barrel cortex while the dorsolateral striatum was mapped with a 500- m resolution, resulting in a maximum of 315 recording positions per animal. Significant event-related responses were unevenly distributed throughout the striatum in 34.8% of positions recorded within this area. Only 10.3% of recorded positions displayed significant total power increases in the LFPs during the stimulation period at the stimulus frequency. This suggests that the responses seen in the LFPs are due to phase rearrangement rather than an amplitude increase in the signal. Analysis of corticostriatal imaginary coherence revealed stimulus-induced changes in the functional connectivity of 12% of corticostriatal pairs, the sensory response of sparsely distributed neuronal ensembles within the dorsolateral striatum is reflected in the phase relationship between the cortical and striatal local fields.
AB - The striatum integrates sensory information to enable action selection and behavioural reinforcement. In the rat, a large topographical projection from the rat barrel cortex to widely distributed areas of the striatum is assumed to be an important structural component supporting these processes. The striatal sensory response is, however, not comprehensively understood at a network level. We used a 10-Hz, 100-ms air puff, allowing undamped movement of multiple whiskers, to look at functional connectivity in contralateral cortex and striatum in response to sensory stimulation. Simultaneous recordings of cortical and striatal local field potentials (LFPs) were made under isoflurane anaesthesia in 15 male Brown Norway rats. Four electrodes were placed in the barrel cortex while the dorsolateral striatum was mapped with a 500- m resolution, resulting in a maximum of 315 recording positions per animal. Significant event-related responses were unevenly distributed throughout the striatum in 34.8% of positions recorded within this area. Only 10.3% of recorded positions displayed significant total power increases in the LFPs during the stimulation period at the stimulus frequency. This suggests that the responses seen in the LFPs are due to phase rearrangement rather than an amplitude increase in the signal. Analysis of corticostriatal imaginary coherence revealed stimulus-induced changes in the functional connectivity of 12% of corticostriatal pairs, the sensory response of sparsely distributed neuronal ensembles within the dorsolateral striatum is reflected in the phase relationship between the cortical and striatal local fields.
KW - Animals
KW - Male
KW - Rats
KW - Brain Mapping
KW - Vibrissae innervation
KW - Evoked Potentials physiology
KW - Afferent Pathways cytology
KW - Corpus Striatum cytology
KW - Animals
KW - Male
KW - Rats
KW - Brain Mapping
KW - Vibrissae innervation
KW - Evoked Potentials physiology
KW - Afferent Pathways cytology
KW - Corpus Striatum cytology
M3 - SCORING: Zeitschriftenaufsatz
VL - 33
SP - 461
EP - 470
JO - EUR J NEUROSCI
JF - EUR J NEUROSCI
SN - 0953-816X
IS - 3
M1 - 3
ER -