Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial
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Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial. / Ranieri, V Marco; Pettilä, Ville; Karvonen, Matti K; Jalkanen, Juho; Nightingale, Peter; Brealey, David; Mancebo, Jordi; Ferrer, Ricard; Mercat, Alain; Patroniti, Nicolò; Quintel, Michael; Vincent, Jean-Louis; Okkonen, Marjatta; Meziani, Ferhat; Bellani, Giacomo; MacCallum, Niall; Creteur, Jacques; Kluge, Stefan; Artigas-Raventos, Antonio; Maksimow, Mikael; Piippo, Ilse; Elima, Kati; Jalkanen, Sirpa; Jalkanen, Markku; Bellingan, Geoff; INTEREST Study Group.
In: JAMA-J AM MED ASSOC, Vol. 323, No. 8, 25.02.2020, p. 725-733.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial
AU - Ranieri, V Marco
AU - Pettilä, Ville
AU - Karvonen, Matti K
AU - Jalkanen, Juho
AU - Nightingale, Peter
AU - Brealey, David
AU - Mancebo, Jordi
AU - Ferrer, Ricard
AU - Mercat, Alain
AU - Patroniti, Nicolò
AU - Quintel, Michael
AU - Vincent, Jean-Louis
AU - Okkonen, Marjatta
AU - Meziani, Ferhat
AU - Bellani, Giacomo
AU - MacCallum, Niall
AU - Creteur, Jacques
AU - Kluge, Stefan
AU - Artigas-Raventos, Antonio
AU - Maksimow, Mikael
AU - Piippo, Ilse
AU - Elima, Kati
AU - Jalkanen, Sirpa
AU - Jalkanen, Markku
AU - Bellingan, Geoff
AU - INTEREST Study Group
PY - 2020/2/25
Y1 - 2020/2/25
N2 - Importance: Acute respiratory distress syndrome (ARDS) is associated with high mortality. Interferon (IFN) β-1a may prevent the underlying event of vascular leakage.Objective: To determine the efficacy and adverse events of IFN-β-1a in patients with moderate to severe ARDS.Design, Setting, and Participants: Multicenter, randomized, double-blind, parallel-group trial conducted at 74 intensive care units in 8 European countries (December 2015-December 2017) that included 301 adults with moderate to severe ARDS according to the Berlin definition. The radiological and partial pressure of oxygen, arterial (Pao2)/fraction of inspired oxygen (Fio2) criteria for ARDS had to be met within a 24-hour period, and the administration of the first dose of the study drug had to occur within 48 hours of the diagnosis of ARDS. The last patient visit was on March 6, 2018.Interventions: Patients were randomized to receive an intravenous injection of 10 μg of IFN-β-1a (144 patients) or placebo (152 patients) once daily for 6 days.Main Outcomes and Measures: The primary outcome was a score combining death and number of ventilator-free days at day 28 (score ranged from -1 for death to 27 if the patient was off ventilator on the first day). There were 16 secondary outcomes, including 28-day mortality, which were tested hierarchically to control type I error.Results: Among 301 patients who were randomized (mean age, 58 years; 103 women [34.2%]), 296 (98.3%) completed the trial and were included in the primary analysis. At 28 days, the median composite score of death and number of ventilator-free days at day 28 was 10 days (interquartile range, -1 to 20) in the IFN-β-1a group and 8.5 days (interquartile range, 0 to 20) in the placebo group (P = .82). There was no significant difference in 28-day mortality between the IFN-β-1a vs placebo groups (26.4% vs 23.0%; difference, 3.4% [95% CI, -8.1% to 14.8%]; P = .53). Seventy-four patients (25.0%) experienced adverse events considered to be related to treatment during the study (41 patients [28.5%] in the IFN-β-1a group and 33 [21.7%] in the placebo group).Conclusions and Relevance: Among adults with moderate or severe ARDS, intravenous IFN-β-1a administered for 6 days, compared with placebo, resulted in no significant difference in a composite score that included death and number of ventilator-free days over 28 days. These results do not support the use of IFN-β-1a in the management of ARDS.Trial Registration: ClinicalTrials.gov Identifier: NCT02622724.
AB - Importance: Acute respiratory distress syndrome (ARDS) is associated with high mortality. Interferon (IFN) β-1a may prevent the underlying event of vascular leakage.Objective: To determine the efficacy and adverse events of IFN-β-1a in patients with moderate to severe ARDS.Design, Setting, and Participants: Multicenter, randomized, double-blind, parallel-group trial conducted at 74 intensive care units in 8 European countries (December 2015-December 2017) that included 301 adults with moderate to severe ARDS according to the Berlin definition. The radiological and partial pressure of oxygen, arterial (Pao2)/fraction of inspired oxygen (Fio2) criteria for ARDS had to be met within a 24-hour period, and the administration of the first dose of the study drug had to occur within 48 hours of the diagnosis of ARDS. The last patient visit was on March 6, 2018.Interventions: Patients were randomized to receive an intravenous injection of 10 μg of IFN-β-1a (144 patients) or placebo (152 patients) once daily for 6 days.Main Outcomes and Measures: The primary outcome was a score combining death and number of ventilator-free days at day 28 (score ranged from -1 for death to 27 if the patient was off ventilator on the first day). There were 16 secondary outcomes, including 28-day mortality, which were tested hierarchically to control type I error.Results: Among 301 patients who were randomized (mean age, 58 years; 103 women [34.2%]), 296 (98.3%) completed the trial and were included in the primary analysis. At 28 days, the median composite score of death and number of ventilator-free days at day 28 was 10 days (interquartile range, -1 to 20) in the IFN-β-1a group and 8.5 days (interquartile range, 0 to 20) in the placebo group (P = .82). There was no significant difference in 28-day mortality between the IFN-β-1a vs placebo groups (26.4% vs 23.0%; difference, 3.4% [95% CI, -8.1% to 14.8%]; P = .53). Seventy-four patients (25.0%) experienced adverse events considered to be related to treatment during the study (41 patients [28.5%] in the IFN-β-1a group and 33 [21.7%] in the placebo group).Conclusions and Relevance: Among adults with moderate or severe ARDS, intravenous IFN-β-1a administered for 6 days, compared with placebo, resulted in no significant difference in a composite score that included death and number of ventilator-free days over 28 days. These results do not support the use of IFN-β-1a in the management of ARDS.Trial Registration: ClinicalTrials.gov Identifier: NCT02622724.
U2 - 10.1001/jama.2019.22525
DO - 10.1001/jama.2019.22525
M3 - SCORING: Journal article
C2 - 32065831
VL - 323
SP - 725
EP - 733
JO - JAMA-J AM MED ASSOC
JF - JAMA-J AM MED ASSOC
SN - 0098-7484
IS - 8
ER -