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Effect of incomplete parathyroidectomy preserving entire parathyroid glands on renal graft function

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Effect of incomplete parathyroidectomy preserving entire parathyroid glands on renal graft function. / Jäger, Mark D; Kaaden, Stephan; Emmanouilidis, Nikos; Lück, Rainer; Beckmann, Jan H; Güner, Zeynep; Kespohl, Holger; Glockzin, Kristina; Aselmann, Heiko; Kaudel, Christian P; Schwarz, Anke; Zapf, Antonia; Klempnauer, Jürgen; Scheumann, Georg F W.

In: ARCH SURG-CHICAGO, Vol. 146, No. 6, 06.2011, p. 704-10.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jäger, MD, Kaaden, S, Emmanouilidis, N, Lück, R, Beckmann, JH, Güner, Z, Kespohl, H, Glockzin, K, Aselmann, H, Kaudel, CP, Schwarz, A, Zapf, A, Klempnauer, J & Scheumann, GFW 2011, 'Effect of incomplete parathyroidectomy preserving entire parathyroid glands on renal graft function', ARCH SURG-CHICAGO, vol. 146, no. 6, pp. 704-10. https://doi.org/10.1001/archsurg.2011.138

APA

Jäger, M. D., Kaaden, S., Emmanouilidis, N., Lück, R., Beckmann, J. H., Güner, Z., Kespohl, H., Glockzin, K., Aselmann, H., Kaudel, C. P., Schwarz, A., Zapf, A., Klempnauer, J., & Scheumann, G. F. W. (2011). Effect of incomplete parathyroidectomy preserving entire parathyroid glands on renal graft function. ARCH SURG-CHICAGO, 146(6), 704-10. https://doi.org/10.1001/archsurg.2011.138

Vancouver

Jäger MD, Kaaden S, Emmanouilidis N, Lück R, Beckmann JH, Güner Z et al. Effect of incomplete parathyroidectomy preserving entire parathyroid glands on renal graft function. ARCH SURG-CHICAGO. 2011 Jun;146(6):704-10. https://doi.org/10.1001/archsurg.2011.138

Bibtex

@article{27e87d0f251f4242ab553d543feafe0c,
title = "Effect of incomplete parathyroidectomy preserving entire parathyroid glands on renal graft function",
abstract = "HYPOTHESIS: Parathyroidectomy (PT) corrects tertiary hyperparathyroidism in patients who have received renal grafts but can result in deterioration of renal function.OBJECTIVE: To compare different surgical procedures for their effect on renal function and efficacy to cure tertiary hyperparathyroidism.DESIGN: A retrospective cohort study.SETTING: University clinic.PATIENTS: Eighty-three patients with functioning renal grafts receiving PT for the first time.INTERVENTIONS: Group 1 received an incomplete PT, with at least 1 entire parathyroid gland (PG) remaining in situ (n = 12). Group 2 received an incomplete PT, with the most morphologically conserved PG partially resected (n = 22). Group 3 received a complete PT, with autotransplantation of PG tissue (n = 49).MAIN OUTCOMES MEASURES: The primary end point was the postoperative change in glomerular filtration rate. Secondary end points were rates of redialysis, hypercalcemia, and hyperparathyroidism within 5 years.RESULTS: A decrease in glomerular filtration rate occurred postoperatively in 75 patients (90%) and correlated significantly with the extent of PG resection. Recovery of renal function at month 6 was observed in group 1, but not in groups 2 and 3 (P < .001). Seven patients (8%) needed permanent dialysis (1 in group 2 and 6 in group 3). Hypercalcemia was abrogated in 78 patients (94%), without significant differences among the groups. Assessment of parathyroid hormone levels in accordance with target ranges from the Kidney Disease Outcomes Quality Initiative guidelines did not reveal significant differences in the rates of recurrent hyperparathyroidism.CONCLUSION: Incomplete PT preserving at least 1 entire PG does not cause deterioration of renal graft function and provides long-term correction of hypercalcemia and tertiary hyperparathyroidism.",
keywords = "Glomerular Filtration Rate, Humans, Hypercalcemia, Hyperparathyroidism, Secondary, Kidney Function Tests, Kidney Transplantation, Middle Aged, Parathyroid Hormone, Parathyroidectomy, Journal Article, Research Support, Non-U.S. Gov't",
author = "J{\"a}ger, {Mark D} and Stephan Kaaden and Nikos Emmanouilidis and Rainer L{\"u}ck and Beckmann, {Jan H} and Zeynep G{\"u}ner and Holger Kespohl and Kristina Glockzin and Heiko Aselmann and Kaudel, {Christian P} and Anke Schwarz and Antonia Zapf and J{\"u}rgen Klempnauer and Scheumann, {Georg F W}",
year = "2011",
month = jun,
doi = "10.1001/archsurg.2011.138",
language = "English",
volume = "146",
pages = "704--10",
number = "6",

}

RIS

TY - JOUR

T1 - Effect of incomplete parathyroidectomy preserving entire parathyroid glands on renal graft function

AU - Jäger, Mark D

AU - Kaaden, Stephan

AU - Emmanouilidis, Nikos

AU - Lück, Rainer

AU - Beckmann, Jan H

AU - Güner, Zeynep

AU - Kespohl, Holger

AU - Glockzin, Kristina

AU - Aselmann, Heiko

AU - Kaudel, Christian P

AU - Schwarz, Anke

AU - Zapf, Antonia

AU - Klempnauer, Jürgen

AU - Scheumann, Georg F W

PY - 2011/6

Y1 - 2011/6

N2 - HYPOTHESIS: Parathyroidectomy (PT) corrects tertiary hyperparathyroidism in patients who have received renal grafts but can result in deterioration of renal function.OBJECTIVE: To compare different surgical procedures for their effect on renal function and efficacy to cure tertiary hyperparathyroidism.DESIGN: A retrospective cohort study.SETTING: University clinic.PATIENTS: Eighty-three patients with functioning renal grafts receiving PT for the first time.INTERVENTIONS: Group 1 received an incomplete PT, with at least 1 entire parathyroid gland (PG) remaining in situ (n = 12). Group 2 received an incomplete PT, with the most morphologically conserved PG partially resected (n = 22). Group 3 received a complete PT, with autotransplantation of PG tissue (n = 49).MAIN OUTCOMES MEASURES: The primary end point was the postoperative change in glomerular filtration rate. Secondary end points were rates of redialysis, hypercalcemia, and hyperparathyroidism within 5 years.RESULTS: A decrease in glomerular filtration rate occurred postoperatively in 75 patients (90%) and correlated significantly with the extent of PG resection. Recovery of renal function at month 6 was observed in group 1, but not in groups 2 and 3 (P < .001). Seven patients (8%) needed permanent dialysis (1 in group 2 and 6 in group 3). Hypercalcemia was abrogated in 78 patients (94%), without significant differences among the groups. Assessment of parathyroid hormone levels in accordance with target ranges from the Kidney Disease Outcomes Quality Initiative guidelines did not reveal significant differences in the rates of recurrent hyperparathyroidism.CONCLUSION: Incomplete PT preserving at least 1 entire PG does not cause deterioration of renal graft function and provides long-term correction of hypercalcemia and tertiary hyperparathyroidism.

AB - HYPOTHESIS: Parathyroidectomy (PT) corrects tertiary hyperparathyroidism in patients who have received renal grafts but can result in deterioration of renal function.OBJECTIVE: To compare different surgical procedures for their effect on renal function and efficacy to cure tertiary hyperparathyroidism.DESIGN: A retrospective cohort study.SETTING: University clinic.PATIENTS: Eighty-three patients with functioning renal grafts receiving PT for the first time.INTERVENTIONS: Group 1 received an incomplete PT, with at least 1 entire parathyroid gland (PG) remaining in situ (n = 12). Group 2 received an incomplete PT, with the most morphologically conserved PG partially resected (n = 22). Group 3 received a complete PT, with autotransplantation of PG tissue (n = 49).MAIN OUTCOMES MEASURES: The primary end point was the postoperative change in glomerular filtration rate. Secondary end points were rates of redialysis, hypercalcemia, and hyperparathyroidism within 5 years.RESULTS: A decrease in glomerular filtration rate occurred postoperatively in 75 patients (90%) and correlated significantly with the extent of PG resection. Recovery of renal function at month 6 was observed in group 1, but not in groups 2 and 3 (P < .001). Seven patients (8%) needed permanent dialysis (1 in group 2 and 6 in group 3). Hypercalcemia was abrogated in 78 patients (94%), without significant differences among the groups. Assessment of parathyroid hormone levels in accordance with target ranges from the Kidney Disease Outcomes Quality Initiative guidelines did not reveal significant differences in the rates of recurrent hyperparathyroidism.CONCLUSION: Incomplete PT preserving at least 1 entire PG does not cause deterioration of renal graft function and provides long-term correction of hypercalcemia and tertiary hyperparathyroidism.

KW - Glomerular Filtration Rate

KW - Humans

KW - Hypercalcemia

KW - Hyperparathyroidism, Secondary

KW - Kidney Function Tests

KW - Kidney Transplantation

KW - Middle Aged

KW - Parathyroid Hormone

KW - Parathyroidectomy

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1001/archsurg.2011.138

DO - 10.1001/archsurg.2011.138

M3 - SCORING: Journal article

C2 - 21690447

VL - 146

SP - 704

EP - 710

IS - 6

ER -