Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study.
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Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study. / Mueller, Sabine; Polley, Mei-Yin; Lee, Benjamin; Kunwar, Sandeep; Pedain, Christoph; Wembacher-Schröder, Eva; Mittermeyer, Stephan; Westphal, Manfred; Sampson, John H; Vogelbaum, Michael A; Croteau, David; Chang, Susan M.
In: J NEURO-ONCOL, Vol. 101, No. 2, 2, 2011, p. 267-277.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study.
AU - Mueller, Sabine
AU - Polley, Mei-Yin
AU - Lee, Benjamin
AU - Kunwar, Sandeep
AU - Pedain, Christoph
AU - Wembacher-Schröder, Eva
AU - Mittermeyer, Stephan
AU - Westphal, Manfred
AU - Sampson, John H
AU - Vogelbaum, Michael A
AU - Croteau, David
AU - Chang, Susan M
PY - 2011
Y1 - 2011
N2 - The PRECISE study used convection enhanced delivery (CED) to infuse IL13-PE38QQR in patients with recurrent glioblastoma multiforme (GBM) and compared survival to Gliadel Wafers (GW). The objectives of this retrospective evaluation were to assess: (1) catheter positioning in relation to imaging features and (2) to examine the potential impact of catheter positioning, overall catheter placement and imaging features on long term clinical outcome in the PRECISE study. Catheter positioning and overall catheter placement were scored and used as a surrogate of adequate placement. Imaging studies obtained on day 43 and day 71 after resection were each retrospectively reviewed. Catheter positioning scores, catheter overall placement scores, local tumor control and imaging change scores were reviewed and correlated using Generalized Linear Mixed Models. Cox PH regression analysis was used to examine whether these imaging based variables predicted overall survival (OS) and progression free survival (PFS) after adjusting for age and KPS. Of 180 patients in the CED group, 20 patients did not undergo gross total resection. Of the remaining 160 patients only 53% of patients had fully conforming catheters in respect to overall placement and 51% had adequate catheter positioning scores. Better catheter positioning scores were not correlated with local tumor control (P = 0.61) or imaging change score (P = 0.86). OS and PFS were not correlated with catheter positioning score (OS: P = 0.53; PFS: P = 0.72 respectively), overall placement score (OS: P = 0.55; PFS: P = 0.35) or imaging changes on day 43 MRI (P = 0.88). Catheter positioning scores and overall catheter placement scores were not associated with clinical outcome in this large prospective trial.
AB - The PRECISE study used convection enhanced delivery (CED) to infuse IL13-PE38QQR in patients with recurrent glioblastoma multiforme (GBM) and compared survival to Gliadel Wafers (GW). The objectives of this retrospective evaluation were to assess: (1) catheter positioning in relation to imaging features and (2) to examine the potential impact of catheter positioning, overall catheter placement and imaging features on long term clinical outcome in the PRECISE study. Catheter positioning and overall catheter placement were scored and used as a surrogate of adequate placement. Imaging studies obtained on day 43 and day 71 after resection were each retrospectively reviewed. Catheter positioning scores, catheter overall placement scores, local tumor control and imaging change scores were reviewed and correlated using Generalized Linear Mixed Models. Cox PH regression analysis was used to examine whether these imaging based variables predicted overall survival (OS) and progression free survival (PFS) after adjusting for age and KPS. Of 180 patients in the CED group, 20 patients did not undergo gross total resection. Of the remaining 160 patients only 53% of patients had fully conforming catheters in respect to overall placement and 51% had adequate catheter positioning scores. Better catheter positioning scores were not correlated with local tumor control (P = 0.61) or imaging change score (P = 0.86). OS and PFS were not correlated with catheter positioning score (OS: P = 0.53; PFS: P = 0.72 respectively), overall placement score (OS: P = 0.55; PFS: P = 0.35) or imaging changes on day 43 MRI (P = 0.88). Catheter positioning scores and overall catheter placement scores were not associated with clinical outcome in this large prospective trial.
KW - Humans
KW - Treatment Outcome
KW - Follow-Up Studies
KW - Combined Modality Therapy
KW - Disease-Free Survival
KW - Proportional Hazards Models
KW - Odds Ratio
KW - Karnofsky Performance Status
KW - Retrospective Studies
KW - Magnetic Resonance Imaging methods
KW - International Cooperation
KW - Neoplasm Recurrence, Local drug therapy
KW - Catheters
KW - Central Nervous System Neoplasms diagnosis
KW - Exotoxins therapeutic use
KW - Glioblastoma diagnosis
KW - Immunologic Factors therapeutic use
KW - Interleukin-13 therapeutic use
KW - Linear Models
KW - Humans
KW - Treatment Outcome
KW - Follow-Up Studies
KW - Combined Modality Therapy
KW - Disease-Free Survival
KW - Proportional Hazards Models
KW - Odds Ratio
KW - Karnofsky Performance Status
KW - Retrospective Studies
KW - Magnetic Resonance Imaging methods
KW - International Cooperation
KW - Neoplasm Recurrence, Local drug therapy
KW - Catheters
KW - Central Nervous System Neoplasms diagnosis
KW - Exotoxins therapeutic use
KW - Glioblastoma diagnosis
KW - Immunologic Factors therapeutic use
KW - Interleukin-13 therapeutic use
KW - Linear Models
M3 - SCORING: Zeitschriftenaufsatz
VL - 101
SP - 267
EP - 277
JO - J NEURO-ONCOL
JF - J NEURO-ONCOL
SN - 0167-594X
IS - 2
M1 - 2
ER -
