Dopaminergic modulation of novelty repetition in Parkinson’s disease: A study of P3 event-related brain potentials

TY - JOUR

T1 - Dopaminergic modulation of novelty repetition in Parkinson’s disease: A study of P3 event-related brain potentials

AU - Bertram, Malte

AU - Warren, Claire

AU - Lange, Florian

AU - Seer, Caroline

AU - Steinke, Alexander

AU - Wegner, Florian

AU - Schrader, Christoph

AU - Dressler, Dirk

AU - Dengler, Reinhard

AU - Kopp, Bruno

PY - 2020

Y1 - 2020

N2 - ObjectiveParkinson’s Disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons. Cognitive impairments have been reported using the event-related potential (ERP) technique. Patients show reduced novelty P3 (nP3) amplitudes in oddball experiments, a response to infrequent, surprising stimuli, linked to the orienting response of the brain. The nP3 is thought to depend on dopaminergic neuronal pathways though the effect of dopaminergic medication in PD has not yet been investigated.MethodsTwenty-two patients with PD were examined “on” and “off” their regular dopaminergic medication in a novelty 3-stimulus-oddball task. Thirty-four healthy controls were also examined over two sessions, but received no medication. P3 amplitudes were compared throughout experimental conditions.ResultsAll participants showed sizeable novelty difference ERP effects, i.e. ndP3 amplitudes, during both testing sessions. An interaction of diagnosis, medication and testing order was also found, indicating that dopaminergic medication modulated ndP3 in patients with PD across the two testing sessions: We observed enhanced ndP3 amplitudes from PD patients who were off medication on the second testing session.ConclusionPatients with PD ‘off’ medication showed ERP evidence for repetition-related enhancement of novelty responses. Dopamine depletion in neuronal pathways that are affected by mid-stage PD possibly accounts for this modulation of novelty processing.SignificanceThe data in this study potentially suggest that repetition effects on novelty processing in patients with PD are enhanced by dopaminergic depletion.

AB - ObjectiveParkinson’s Disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons. Cognitive impairments have been reported using the event-related potential (ERP) technique. Patients show reduced novelty P3 (nP3) amplitudes in oddball experiments, a response to infrequent, surprising stimuli, linked to the orienting response of the brain. The nP3 is thought to depend on dopaminergic neuronal pathways though the effect of dopaminergic medication in PD has not yet been investigated.MethodsTwenty-two patients with PD were examined “on” and “off” their regular dopaminergic medication in a novelty 3-stimulus-oddball task. Thirty-four healthy controls were also examined over two sessions, but received no medication. P3 amplitudes were compared throughout experimental conditions.ResultsAll participants showed sizeable novelty difference ERP effects, i.e. ndP3 amplitudes, during both testing sessions. An interaction of diagnosis, medication and testing order was also found, indicating that dopaminergic medication modulated ndP3 in patients with PD across the two testing sessions: We observed enhanced ndP3 amplitudes from PD patients who were off medication on the second testing session.ConclusionPatients with PD ‘off’ medication showed ERP evidence for repetition-related enhancement of novelty responses. Dopamine depletion in neuronal pathways that are affected by mid-stage PD possibly accounts for this modulation of novelty processing.SignificanceThe data in this study potentially suggest that repetition effects on novelty processing in patients with PD are enhanced by dopaminergic depletion.

U2 - 10.1016/j.clinph.2020.09.013

DO - 10.1016/j.clinph.2020.09.013

M3 - SCORING: Journal article

VL - 131

SP - 2841

EP - 2850

JO - CLIN NEUROPHYSIOL

JF - CLIN NEUROPHYSIOL

SN - 1388-2457

IS - 12

ER -