Dopaminergic mechanisms of target detection - P300 event related potential and striatal dopamine.
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Dopaminergic mechanisms of target detection - P300 event related potential and striatal dopamine. / Pogarell, Oliver; Padberg, Frank; Karch, Susanne; Segmiller, Felix; Juckel, Georg; Mulert, Christoph; Hegerl, Ulrich; Tatsch, Klaus; Koch, Walter.
In: PSYCHIAT RES, Vol. 194, No. 3, 3, 2011, p. 212-218.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Dopaminergic mechanisms of target detection - P300 event related potential and striatal dopamine.
AU - Pogarell, Oliver
AU - Padberg, Frank
AU - Karch, Susanne
AU - Segmiller, Felix
AU - Juckel, Georg
AU - Mulert, Christoph
AU - Hegerl, Ulrich
AU - Tatsch, Klaus
AU - Koch, Walter
PY - 2011
Y1 - 2011
N2 - The P300 is a cortically generated event related potential (ERP) widely used in neurophysiological research since it is related to cognitive functions and central information processing. Intracerebral recordings and functional neuroimaging studies have demonstrated that this potential is generated by various brain regions including frontal, temporal and parietal cortices. Regarding the neurochemical background, clinical and genetic investigations suggest that dopaminergic neurons could be involved in the generation of the P300. However, there is no direct evidence in vivo that P300 amplitudes and latencies are related to dopaminergic parameters. The aim of this study was to further elucidate dopaminergic aspects of the P300 ERP by combining neurophysiological and nuclear medicine assessments in vivo. Patients with a major depressive episode underwent both P300 recordings and dynamic [¹²³I] IBZM SPECT for the evaluation of striatal dopamine D?/D?-receptor availability. There were statistically significant positive correlations of the striatal dopamine D?/D?-receptor status with P300 amplitudes and significant negative correlations with P300 latencies. Using this combined approach, the study presents direct evidence in vivo that the central dopaminergic system might play an important role in the generation of the P300 and that central dopaminergic activity could be involved in the modulation of P300 parameters. This association might be of relevance for the interpretation of P300 studies in psychiatric disorders.
AB - The P300 is a cortically generated event related potential (ERP) widely used in neurophysiological research since it is related to cognitive functions and central information processing. Intracerebral recordings and functional neuroimaging studies have demonstrated that this potential is generated by various brain regions including frontal, temporal and parietal cortices. Regarding the neurochemical background, clinical and genetic investigations suggest that dopaminergic neurons could be involved in the generation of the P300. However, there is no direct evidence in vivo that P300 amplitudes and latencies are related to dopaminergic parameters. The aim of this study was to further elucidate dopaminergic aspects of the P300 ERP by combining neurophysiological and nuclear medicine assessments in vivo. Patients with a major depressive episode underwent both P300 recordings and dynamic [¹²³I] IBZM SPECT for the evaluation of striatal dopamine D?/D?-receptor availability. There were statistically significant positive correlations of the striatal dopamine D?/D?-receptor status with P300 amplitudes and significant negative correlations with P300 latencies. Using this combined approach, the study presents direct evidence in vivo that the central dopaminergic system might play an important role in the generation of the P300 and that central dopaminergic activity could be involved in the modulation of P300 parameters. This association might be of relevance for the interpretation of P300 studies in psychiatric disorders.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Time Factors
KW - Statistics, Nonparametric
KW - Brain Mapping
KW - Benzamides/metabolism/pharmacokinetics
KW - Corpus Striatum/drug effects/metabolism/radionuclide imaging
KW - Depressive Disorder, Major/pathology/physiopathology/radionuclide imaging
KW - Dopamine/metabolism
KW - Electroencephalography/methods
KW - Event-Related Potentials, P300/physiology
KW - Iodine Isotopes/metabolism/pharmacokinetics
KW - Pyrrolidines/metabolism/pharmacokinetics
KW - Tomography, Emission-Computed, Single-Photon/methods
KW - Transcranial Magnetic Stimulation/methods
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Time Factors
KW - Statistics, Nonparametric
KW - Brain Mapping
KW - Benzamides/metabolism/pharmacokinetics
KW - Corpus Striatum/drug effects/metabolism/radionuclide imaging
KW - Depressive Disorder, Major/pathology/physiopathology/radionuclide imaging
KW - Dopamine/metabolism
KW - Electroencephalography/methods
KW - Event-Related Potentials, P300/physiology
KW - Iodine Isotopes/metabolism/pharmacokinetics
KW - Pyrrolidines/metabolism/pharmacokinetics
KW - Tomography, Emission-Computed, Single-Photon/methods
KW - Transcranial Magnetic Stimulation/methods
M3 - SCORING: Journal article
VL - 194
SP - 212
EP - 218
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 3
M1 - 3
ER -
