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Distribution of histopathological features along the colon in microscopic colitis

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Distribution of histopathological features along the colon in microscopic colitis. / Fiehn, Anne-Marie Kanstrup; Miehlke, Stephan; Aust, Daniela; Vieth, Michael; Bonderup, Ole; Fernández-Bañares, Fernando; Mihaly, Emese; Kupcinskas, Juozas; Madisch, Ahmed; Munck, Lars Kristian; Nacak, Tanju; Mohrbacher, Ralf; Mueller, Ralph; Greinwald, Roland; Münch, Andreas.

In: INT J COLORECTAL DIS, Vol. 36, No. 1, 01.2021, p. 151-159.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fiehn, A-MK, Miehlke, S, Aust, D, Vieth, M, Bonderup, O, Fernández-Bañares, F, Mihaly, E, Kupcinskas, J, Madisch, A, Munck, LK, Nacak, T, Mohrbacher, R, Mueller, R, Greinwald, R & Münch, A 2021, 'Distribution of histopathological features along the colon in microscopic colitis', INT J COLORECTAL DIS, vol. 36, no. 1, pp. 151-159. https://doi.org/10.1007/s00384-020-03747-z

APA

Fiehn, A-M. K., Miehlke, S., Aust, D., Vieth, M., Bonderup, O., Fernández-Bañares, F., Mihaly, E., Kupcinskas, J., Madisch, A., Munck, L. K., Nacak, T., Mohrbacher, R., Mueller, R., Greinwald, R., & Münch, A. (2021). Distribution of histopathological features along the colon in microscopic colitis. INT J COLORECTAL DIS, 36(1), 151-159. https://doi.org/10.1007/s00384-020-03747-z

Vancouver

Fiehn A-MK, Miehlke S, Aust D, Vieth M, Bonderup O, Fernández-Bañares F et al. Distribution of histopathological features along the colon in microscopic colitis. INT J COLORECTAL DIS. 2021 Jan;36(1):151-159. https://doi.org/10.1007/s00384-020-03747-z

Bibtex

@article{dd0771a97ea24d8e94a2919124001302,
title = "Distribution of histopathological features along the colon in microscopic colitis",
abstract = "PURPOSE: The diagnosis microscopic colitis (MC) consisting of collagenous colitis (CC) and lymphocytic colitis (LC) relies on histological assessment of mucosal biopsies from the colon. The optimal biopsy strategy for reliable diagnosis of MC is controversial. The aim of this study was to evaluate the distribution of histopathological features of MC throughout the colon.METHODS: Mucosal biopsies from multiple colonic segments of patients with MC who participated in one of the three prospective European multicenter trials were analyzed. Histological slides were stained with hematoxylin-and-eosin, a connective tissue stain, and CD3 in selected cases.RESULTS: In total, 255 patients were included, 199 and 56 patients with CC and LC, respectively. Both groups exhibited a gradient with more pronounced inflammation in the lamina propria in the proximal colon compared with the distal colon. Similarly, the thickness of the subepithelial collagenous band in CC showed a gradient with higher values in the proximal colon. The mean number of intraepithelial lymphocytes was > 20 in all colonic segments in patients within both subgroups. Biopsies from 86 to 94% of individual segments were diagnostic, rectum excluded. Biopsies from non-diagnostic segments often showed features of another subgroup of MC.CONCLUSION: Conclusively, although the severity of the histological changes in MC differed in the colonic mucosa, the minimum criteria required for the diagnosis were present in the random biopsies from the majority of segments. Thus, our findings show MC to be a pancolitis, rectum excluded, questioning previously proclaimed patchiness throughout the colon.",
author = "Fiehn, {Anne-Marie Kanstrup} and Stephan Miehlke and Daniela Aust and Michael Vieth and Ole Bonderup and Fernando Fern{\'a}ndez-Ba{\~n}ares and Emese Mihaly and Juozas Kupcinskas and Ahmed Madisch and Munck, {Lars Kristian} and Tanju Nacak and Ralf Mohrbacher and Ralph Mueller and Roland Greinwald and Andreas M{\"u}nch",
year = "2021",
month = jan,
doi = "10.1007/s00384-020-03747-z",
language = "English",
volume = "36",
pages = "151--159",
journal = "INT J COLORECTAL DIS",
issn = "0179-1958",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Distribution of histopathological features along the colon in microscopic colitis

AU - Fiehn, Anne-Marie Kanstrup

AU - Miehlke, Stephan

AU - Aust, Daniela

AU - Vieth, Michael

AU - Bonderup, Ole

AU - Fernández-Bañares, Fernando

AU - Mihaly, Emese

AU - Kupcinskas, Juozas

AU - Madisch, Ahmed

AU - Munck, Lars Kristian

AU - Nacak, Tanju

AU - Mohrbacher, Ralf

AU - Mueller, Ralph

AU - Greinwald, Roland

AU - Münch, Andreas

PY - 2021/1

Y1 - 2021/1

N2 - PURPOSE: The diagnosis microscopic colitis (MC) consisting of collagenous colitis (CC) and lymphocytic colitis (LC) relies on histological assessment of mucosal biopsies from the colon. The optimal biopsy strategy for reliable diagnosis of MC is controversial. The aim of this study was to evaluate the distribution of histopathological features of MC throughout the colon.METHODS: Mucosal biopsies from multiple colonic segments of patients with MC who participated in one of the three prospective European multicenter trials were analyzed. Histological slides were stained with hematoxylin-and-eosin, a connective tissue stain, and CD3 in selected cases.RESULTS: In total, 255 patients were included, 199 and 56 patients with CC and LC, respectively. Both groups exhibited a gradient with more pronounced inflammation in the lamina propria in the proximal colon compared with the distal colon. Similarly, the thickness of the subepithelial collagenous band in CC showed a gradient with higher values in the proximal colon. The mean number of intraepithelial lymphocytes was > 20 in all colonic segments in patients within both subgroups. Biopsies from 86 to 94% of individual segments were diagnostic, rectum excluded. Biopsies from non-diagnostic segments often showed features of another subgroup of MC.CONCLUSION: Conclusively, although the severity of the histological changes in MC differed in the colonic mucosa, the minimum criteria required for the diagnosis were present in the random biopsies from the majority of segments. Thus, our findings show MC to be a pancolitis, rectum excluded, questioning previously proclaimed patchiness throughout the colon.

AB - PURPOSE: The diagnosis microscopic colitis (MC) consisting of collagenous colitis (CC) and lymphocytic colitis (LC) relies on histological assessment of mucosal biopsies from the colon. The optimal biopsy strategy for reliable diagnosis of MC is controversial. The aim of this study was to evaluate the distribution of histopathological features of MC throughout the colon.METHODS: Mucosal biopsies from multiple colonic segments of patients with MC who participated in one of the three prospective European multicenter trials were analyzed. Histological slides were stained with hematoxylin-and-eosin, a connective tissue stain, and CD3 in selected cases.RESULTS: In total, 255 patients were included, 199 and 56 patients with CC and LC, respectively. Both groups exhibited a gradient with more pronounced inflammation in the lamina propria in the proximal colon compared with the distal colon. Similarly, the thickness of the subepithelial collagenous band in CC showed a gradient with higher values in the proximal colon. The mean number of intraepithelial lymphocytes was > 20 in all colonic segments in patients within both subgroups. Biopsies from 86 to 94% of individual segments were diagnostic, rectum excluded. Biopsies from non-diagnostic segments often showed features of another subgroup of MC.CONCLUSION: Conclusively, although the severity of the histological changes in MC differed in the colonic mucosa, the minimum criteria required for the diagnosis were present in the random biopsies from the majority of segments. Thus, our findings show MC to be a pancolitis, rectum excluded, questioning previously proclaimed patchiness throughout the colon.

U2 - 10.1007/s00384-020-03747-z

DO - 10.1007/s00384-020-03747-z

M3 - SCORING: Journal article

C2 - 32920702

VL - 36

SP - 151

EP - 159

JO - INT J COLORECTAL DIS

JF - INT J COLORECTAL DIS

SN - 0179-1958

IS - 1

ER -