Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.
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Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. / Hu, Xinli; Atzler, Dorothee; Xu, Xin; Zhang, Ping; Guo, Haipeng; Lu, Zhongbing; Fassett, John; Schwedhelm, Edzard; Böger, Rainer; Bache, Robert J; Chen, Yingjie.
In: ARTERIOSCL THROM VAS, Vol. 31, No. 7, 7, 2011, p. 1540-1546.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.
AU - Hu, Xinli
AU - Atzler, Dorothee
AU - Xu, Xin
AU - Zhang, Ping
AU - Guo, Haipeng
AU - Lu, Zhongbing
AU - Fassett, John
AU - Schwedhelm, Edzard
AU - Böger, Rainer
AU - Bache, Robert J
AU - Chen, Yingjie
PY - 2011
Y1 - 2011
N2 - The objective of this study was to identify the role of dimethylarginine dimethylaminohydrolase-1 (DDAH1) in degrading the endogenous nitric oxide synthase inhibitors asymmetrical dimethylarginine (ADMA) and N(g)-monomethyl-L-arginine (L-NMMA).
AB - The objective of this study was to identify the role of dimethylarginine dimethylaminohydrolase-1 (DDAH1) in degrading the endogenous nitric oxide synthase inhibitors asymmetrical dimethylarginine (ADMA) and N(g)-monomethyl-L-arginine (L-NMMA).
KW - Animals
KW - Male
KW - Female
KW - Risk Factors
KW - Time Factors
KW - Genotype
KW - Cells, Cultured
KW - Mice
KW - Mice, Knockout
KW - Phenotype
KW - Substrate Specificity
KW - Transfection
KW - Infusion Pumps, Implantable
KW - RNA Interference
KW - Blood Pressure
KW - Nitric Oxide/metabolism
KW - Amidohydrolases/deficiency/genetics/metabolism
KW - Arginine/analogs & derivatives/blood/metabolism
KW - Cardiovascular Diseases/enzymology/etiology/genetics
KW - Endothelial Cells/enzymology
KW - Enzyme Inhibitors/administration & dosage
KW - Hypertension/enzymology/physiopathology
KW - Mice, 129 Strain
KW - NG-Nitroarginine Methyl Ester/administration & dosage
KW - Nitric Oxide Synthase/antagonists & inhibitors/metabolism
KW - omega-N-Methylarginine/metabolism
KW - Animals
KW - Male
KW - Female
KW - Risk Factors
KW - Time Factors
KW - Genotype
KW - Cells, Cultured
KW - Mice
KW - Mice, Knockout
KW - Phenotype
KW - Substrate Specificity
KW - Transfection
KW - Infusion Pumps, Implantable
KW - RNA Interference
KW - Blood Pressure
KW - Nitric Oxide/metabolism
KW - Amidohydrolases/deficiency/genetics/metabolism
KW - Arginine/analogs & derivatives/blood/metabolism
KW - Cardiovascular Diseases/enzymology/etiology/genetics
KW - Endothelial Cells/enzymology
KW - Enzyme Inhibitors/administration & dosage
KW - Hypertension/enzymology/physiopathology
KW - Mice, 129 Strain
KW - NG-Nitroarginine Methyl Ester/administration & dosage
KW - Nitric Oxide Synthase/antagonists & inhibitors/metabolism
KW - omega-N-Methylarginine/metabolism
M3 - SCORING: Journal article
VL - 31
SP - 1540
EP - 1546
JO - ARTERIOSCL THROM VAS
JF - ARTERIOSCL THROM VAS
SN - 1079-5642
IS - 7
M1 - 7
ER -