Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat.
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Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat. / Brockmann, Marco David; Pöschel, Beatrice; Cichon, Nicole; Hanganu-Opatz, Ileana.
In: NEURON, Vol. 71, No. 2, 2, 2011, p. 332-347.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat.
AU - Brockmann, Marco David
AU - Pöschel, Beatrice
AU - Cichon, Nicole
AU - Hanganu-Opatz, Ileana
PY - 2011
Y1 - 2011
N2 - The coactivation of prefrontal and hippocampal networks in oscillatory rhythms is critical for precise information flow in mnemonic and executive tasks, yet the mechanisms governing its development are still unknown. Here, we demonstrate that already in neonatal rats, patterns of discontinuous oscillatory activity precisely entrain the firing of prefrontal neurons and have distinct spatial and temporal organization over cingulate and prelimbic cortices. Moreover, we show that hippocampal theta bursts drive the generation of neonatal prefrontal oscillations by phase-locking the neuronal firing via axonal pathways. Consequently, functional impairment of the hippocampus reduces the prefrontal activity. With ongoing maturation continuous theta-gamma oscillations emerge and mutually entrain the prejuvenile prefrontal-hippocampal networks. Thus, theta-modulated communication within developing prefrontal-hippocampal networks may be relevant for circuitry refinement and maturation of functional units underlying information storage at adulthood.
AB - The coactivation of prefrontal and hippocampal networks in oscillatory rhythms is critical for precise information flow in mnemonic and executive tasks, yet the mechanisms governing its development are still unknown. Here, we demonstrate that already in neonatal rats, patterns of discontinuous oscillatory activity precisely entrain the firing of prefrontal neurons and have distinct spatial and temporal organization over cingulate and prelimbic cortices. Moreover, we show that hippocampal theta bursts drive the generation of neonatal prefrontal oscillations by phase-locking the neuronal firing via axonal pathways. Consequently, functional impairment of the hippocampus reduces the prefrontal activity. With ongoing maturation continuous theta-gamma oscillations emerge and mutually entrain the prejuvenile prefrontal-hippocampal networks. Thus, theta-modulated communication within developing prefrontal-hippocampal networks may be relevant for circuitry refinement and maturation of functional units underlying information storage at adulthood.
KW - Animals
KW - Age Factors
KW - Rats
KW - Animals, Newborn
KW - Analysis of Variance
KW - Action Potentials/drug effects/physiology
KW - Amino Acids/diagnostic use
KW - Anesthetics, Local/pharmacology
KW - Biological Clocks/drug effects/physiology
KW - Electric Stimulation/methods
KW - Fourier Analysis
KW - GABA Plasma Membrane Transport Proteins/metabolism
KW - Hippocampus/cytology/growth & development/injuries
KW - Lidocaine/pharmacology
KW - N-Methylaspartate/toxicity
KW - Neural Pathways/drug effects/growth & development
KW - Neurons/drug effects/physiology
KW - Parvalbumins/metabolism
KW - Prefrontal Cortex/cytology/growth & development/injuries
KW - Animals
KW - Age Factors
KW - Rats
KW - Animals, Newborn
KW - Analysis of Variance
KW - Action Potentials/drug effects/physiology
KW - Amino Acids/diagnostic use
KW - Anesthetics, Local/pharmacology
KW - Biological Clocks/drug effects/physiology
KW - Electric Stimulation/methods
KW - Fourier Analysis
KW - GABA Plasma Membrane Transport Proteins/metabolism
KW - Hippocampus/cytology/growth & development/injuries
KW - Lidocaine/pharmacology
KW - N-Methylaspartate/toxicity
KW - Neural Pathways/drug effects/growth & development
KW - Neurons/drug effects/physiology
KW - Parvalbumins/metabolism
KW - Prefrontal Cortex/cytology/growth & development/injuries
M3 - SCORING: Journal article
VL - 71
SP - 332
EP - 347
JO - NEURON
JF - NEURON
SN - 0896-6273
IS - 2
M1 - 2
ER -
