Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene.
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Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene. / Lindstedt, Fredrik; Berrebi, Jonathan; Greayer, Erik; Lonsdorf, Tina; Schalling, Martin; Ingvar, Martin; Kosek, Eva.
In: PLOS ONE, Vol. 6, No. 3, 3, 2011, p. 18252.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene.
AU - Lindstedt, Fredrik
AU - Berrebi, Jonathan
AU - Greayer, Erik
AU - Lonsdorf, Tina
AU - Schalling, Martin
AU - Ingvar, Martin
AU - Kosek, Eva
PY - 2011
Y1 - 2011
N2 - Variation in the serotonin transporter (5-HTT) gene (SLC6A4) has been shown to influence a wide range of affective processes. Low 5-HTT gene-expression has also been suggested to increase the risk of chronic pain. Conditioned pain modulation (CPM)--i.e. 'pain inhibits pain'--is impaired in chronic pain states and, reciprocally, aberrations of CPM may predict the development of chronic pain. Therefore we hypothesized that a common variation in the SLC6A4 is associated with inter-individual variation in CPM. Forty-five healthy subjects recruited on the basis of tri-allelic 5-HTTLPR genotype, with inferred high or low 5-HTT-expression, were included in a double-blind study. A submaximal-effort tourniquet test was used to provide a standardized degree of conditioning ischemic pain. Individualized noxious heat and pressure pain thresholds (PPTs) were used as subjective test-modalities and the nociceptive flexion reflex (NFR) was used to provide an objective neurophysiological window into spinal processing.
AB - Variation in the serotonin transporter (5-HTT) gene (SLC6A4) has been shown to influence a wide range of affective processes. Low 5-HTT gene-expression has also been suggested to increase the risk of chronic pain. Conditioned pain modulation (CPM)--i.e. 'pain inhibits pain'--is impaired in chronic pain states and, reciprocally, aberrations of CPM may predict the development of chronic pain. Therefore we hypothesized that a common variation in the SLC6A4 is associated with inter-individual variation in CPM. Forty-five healthy subjects recruited on the basis of tri-allelic 5-HTTLPR genotype, with inferred high or low 5-HTT-expression, were included in a double-blind study. A submaximal-effort tourniquet test was used to provide a standardized degree of conditioning ischemic pain. Individualized noxious heat and pressure pain thresholds (PPTs) were used as subjective test-modalities and the nociceptive flexion reflex (NFR) was used to provide an objective neurophysiological window into spinal processing.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Questionnaires
KW - Young Adult
KW - Genotype
KW - Hot Temperature
KW - Pressure
KW - Polymorphism, Single Nucleotide/genetics
KW - Physical Stimulation
KW - Aging/pathology
KW - Conditioning (Psychology)
KW - Nociceptors/metabolism
KW - Pain/genetics/physiopathology
KW - Pain Measurement
KW - Pain Threshold
KW - Reflex/physiology
KW - Serotonin Plasma Membrane Transport Proteins/genetics
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Questionnaires
KW - Young Adult
KW - Genotype
KW - Hot Temperature
KW - Pressure
KW - Polymorphism, Single Nucleotide/genetics
KW - Physical Stimulation
KW - Aging/pathology
KW - Conditioning (Psychology)
KW - Nociceptors/metabolism
KW - Pain/genetics/physiopathology
KW - Pain Measurement
KW - Pain Threshold
KW - Reflex/physiology
KW - Serotonin Plasma Membrane Transport Proteins/genetics
U2 - 10.1371/journal.pone.0018252
DO - 10.1371/journal.pone.0018252
M3 - SCORING: Journal article
VL - 6
SP - 18252
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 3
M1 - 3
ER -
