Comparison of visual evoked potentials and retinal nerve fiber layer thickness in Alzheimer's disease
Standard
Comparison of visual evoked potentials and retinal nerve fiber layer thickness in Alzheimer's disease. / Kromer, Robert; Serbecic, Nermin; Hausner, Lucrezia; Froelich, Lutz; Beutelspacher, Sven C.
In: FRONT NEUROL, Vol. 4, 2013, p. 203.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Comparison of visual evoked potentials and retinal nerve fiber layer thickness in Alzheimer's disease
AU - Kromer, Robert
AU - Serbecic, Nermin
AU - Hausner, Lucrezia
AU - Froelich, Lutz
AU - Beutelspacher, Sven C
PY - 2013
Y1 - 2013
N2 - INTRODUCTION: Alzheimer's disease (AD) is a long term progressive neurodegenerative disease and might affect the retinal nerve fiber layer thickness (RNFLT) of the eye. There is increasing evidence that visual evoked potentials (VEP), which are an objective way to indicate visual field loss, might be affected by the disease as well.MATERIALS AND METHODS: About 22 patients (mean age: 75.9 ± 6.1 years; 14 women) with mild-to-moderate AD and 22 sex-matched healthy patients were examined. We compared the use of VEP and RNFLT using the latest high-resolution spectral domain optical coherence tomography with eye-tracking capabilities for optimized peripapillary scan centering for the first time in AD patients.RESULTS: The mean MMSE score was 22.59 ± 5.47 in the AD group, and did not significantly correlate with the VEP latencies. We found no significant difference between the VEP latencies of the AD patients and those of the control patients. No peripapillary sector of the retina had a RNFLT significantly correlated with the VEP latencies.DISCUSSION: We demonstrated that pattern VEP did not show any significant correlation despite subtle loss in RNFLT. It remains open whether additional flash VEP combined with RNFLT analysis may be useful in diagnosing AD, particularly for mild-to-moderate stages of the disease.
AB - INTRODUCTION: Alzheimer's disease (AD) is a long term progressive neurodegenerative disease and might affect the retinal nerve fiber layer thickness (RNFLT) of the eye. There is increasing evidence that visual evoked potentials (VEP), which are an objective way to indicate visual field loss, might be affected by the disease as well.MATERIALS AND METHODS: About 22 patients (mean age: 75.9 ± 6.1 years; 14 women) with mild-to-moderate AD and 22 sex-matched healthy patients were examined. We compared the use of VEP and RNFLT using the latest high-resolution spectral domain optical coherence tomography with eye-tracking capabilities for optimized peripapillary scan centering for the first time in AD patients.RESULTS: The mean MMSE score was 22.59 ± 5.47 in the AD group, and did not significantly correlate with the VEP latencies. We found no significant difference between the VEP latencies of the AD patients and those of the control patients. No peripapillary sector of the retina had a RNFLT significantly correlated with the VEP latencies.DISCUSSION: We demonstrated that pattern VEP did not show any significant correlation despite subtle loss in RNFLT. It remains open whether additional flash VEP combined with RNFLT analysis may be useful in diagnosing AD, particularly for mild-to-moderate stages of the disease.
U2 - 10.3389/fneur.2013.00203
DO - 10.3389/fneur.2013.00203
M3 - SCORING: Journal article
C2 - 24379800
VL - 4
SP - 203
JO - FRONT NEUROL
JF - FRONT NEUROL
SN - 1664-2295
ER -
