Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials

GRIT Study Group; TRUFFLE Group

doi:10.1002/uog.20354

Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials

Standard

Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials. / GRIT Study Group; TRUFFLE Group.

In: ULTRASOUND OBST GYN, Vol. 55, No. 1, 01.2020, p. 68-74.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

GRIT Study Group & TRUFFLE Group 2020, 'Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials', ULTRASOUND OBST GYN, vol. 55, no. 1, pp. 68-74. https://doi.org/10.1002/uog.20354

APA

GRIT Study Group, & TRUFFLE Group (2020). Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials. ULTRASOUND OBST GYN, 55(1), 68-74. https://doi.org/10.1002/uog.20354

Vancouver

GRIT Study Group, TRUFFLE Group. Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials. ULTRASOUND OBST GYN. 2020 Jan;55(1):68-74. https://doi.org/10.1002/uog.20354

Bibtex

@article{30bb9788746d4a52a503f000446109e9,

title = "Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials",

abstract = "OBJECTIVE: To explore the effect on perinatal outcome of different fetal monitoring strategies for early-onset fetal growth restriction (FGR).METHODS: This was a cohort analysis of individual participant data from two European multicenter trials of fetal monitoring methods for FGR: the Growth Restriction Intervention Study (GRIT) and the Trial of Umbilical and Fetal Flow in Europe (TRUFFLE). All women from GRIT (n = 238) and TRUFFLE (n = 503) who were randomized between 26 and 32 weeks' gestation were included. The women were grouped according to intervention and monitoring method: immediate delivery (GRIT) or delayed delivery with monitoring by conventional cardiotocography (CTG) (GRIT), computerized CTG (cCTG) only (GRIT and TRUFFLE) or cCTG and ductus venosus (DV) Doppler (TRUFFLE). The primary outcome was survival without neurodevelopmental impairment at 2 years of age.RESULTS: Gestational age at delivery and birth weight were similar in both studies. Fetal death rate was similar between the GRIT and TRUFFLE groups, but neonatal and late death were more frequent in GRIT (18% vs 6%; P < 0.01). The rate of survival without impairment at 2 years was lowest in pregnancies that underwent immediate delivery (70% (95% CI, 61-78%)) or delayed delivery with monitoring by CTG (69% (95% CI, 57-82%)), increased in those monitored using cCTG only in both GRIT (80% (95% CI, 68-91%)) and TRUFFLE (77% (95% CI, 70-84%)), and was highest in pregnancies monitored using cCTG and DV Doppler (84% (95% CI, 80-89%)) (P < 0.01 for trend).CONCLUSIONS: This analysis supports the hypothesis that the optimal method for fetal monitoring in pregnancies complicated by early-onset FGR is a combination of cCTG and DV Doppler assessment.TRIAL REGISTRATION: GRIT ISRCTN41358726 and TRUFFLE ISRCTN56204499. {\textcopyright} 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.",

author = "W Ganzevoort and Thornton, {J G} and N Marlow and B Thilaganathan and B Arabin and F Prefumo and C Lees and H Wolf and {GRIT Study Group} and {TRUFFLE Group}",

note = "{\textcopyright} 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.",

year = "2020",

month = jan,

doi = "10.1002/uog.20354",

language = "English",

volume = "55",

pages = "68--74",

journal = "ULTRASOUND OBST GYN",

issn = "0960-7692",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

RIS

TY - JOUR

T1 - Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials

AU - Ganzevoort, W

AU - Thornton, J G

AU - Marlow, N

AU - Thilaganathan, B

AU - Arabin, B

AU - Prefumo, F

AU - Lees, C

AU - Wolf, H

AU - GRIT Study Group

AU - TRUFFLE Group

PY - 2020/1

Y1 - 2020/1

N2 - OBJECTIVE: To explore the effect on perinatal outcome of different fetal monitoring strategies for early-onset fetal growth restriction (FGR).METHODS: This was a cohort analysis of individual participant data from two European multicenter trials of fetal monitoring methods for FGR: the Growth Restriction Intervention Study (GRIT) and the Trial of Umbilical and Fetal Flow in Europe (TRUFFLE). All women from GRIT (n = 238) and TRUFFLE (n = 503) who were randomized between 26 and 32 weeks' gestation were included. The women were grouped according to intervention and monitoring method: immediate delivery (GRIT) or delayed delivery with monitoring by conventional cardiotocography (CTG) (GRIT), computerized CTG (cCTG) only (GRIT and TRUFFLE) or cCTG and ductus venosus (DV) Doppler (TRUFFLE). The primary outcome was survival without neurodevelopmental impairment at 2 years of age.RESULTS: Gestational age at delivery and birth weight were similar in both studies. Fetal death rate was similar between the GRIT and TRUFFLE groups, but neonatal and late death were more frequent in GRIT (18% vs 6%; P < 0.01). The rate of survival without impairment at 2 years was lowest in pregnancies that underwent immediate delivery (70% (95% CI, 61-78%)) or delayed delivery with monitoring by CTG (69% (95% CI, 57-82%)), increased in those monitored using cCTG only in both GRIT (80% (95% CI, 68-91%)) and TRUFFLE (77% (95% CI, 70-84%)), and was highest in pregnancies monitored using cCTG and DV Doppler (84% (95% CI, 80-89%)) (P < 0.01 for trend).CONCLUSIONS: This analysis supports the hypothesis that the optimal method for fetal monitoring in pregnancies complicated by early-onset FGR is a combination of cCTG and DV Doppler assessment.TRIAL REGISTRATION: GRIT ISRCTN41358726 and TRUFFLE ISRCTN56204499. © 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.

AB - OBJECTIVE: To explore the effect on perinatal outcome of different fetal monitoring strategies for early-onset fetal growth restriction (FGR).METHODS: This was a cohort analysis of individual participant data from two European multicenter trials of fetal monitoring methods for FGR: the Growth Restriction Intervention Study (GRIT) and the Trial of Umbilical and Fetal Flow in Europe (TRUFFLE). All women from GRIT (n = 238) and TRUFFLE (n = 503) who were randomized between 26 and 32 weeks' gestation were included. The women were grouped according to intervention and monitoring method: immediate delivery (GRIT) or delayed delivery with monitoring by conventional cardiotocography (CTG) (GRIT), computerized CTG (cCTG) only (GRIT and TRUFFLE) or cCTG and ductus venosus (DV) Doppler (TRUFFLE). The primary outcome was survival without neurodevelopmental impairment at 2 years of age.RESULTS: Gestational age at delivery and birth weight were similar in both studies. Fetal death rate was similar between the GRIT and TRUFFLE groups, but neonatal and late death were more frequent in GRIT (18% vs 6%; P < 0.01). The rate of survival without impairment at 2 years was lowest in pregnancies that underwent immediate delivery (70% (95% CI, 61-78%)) or delayed delivery with monitoring by CTG (69% (95% CI, 57-82%)), increased in those monitored using cCTG only in both GRIT (80% (95% CI, 68-91%)) and TRUFFLE (77% (95% CI, 70-84%)), and was highest in pregnancies monitored using cCTG and DV Doppler (84% (95% CI, 80-89%)) (P < 0.01 for trend).CONCLUSIONS: This analysis supports the hypothesis that the optimal method for fetal monitoring in pregnancies complicated by early-onset FGR is a combination of cCTG and DV Doppler assessment.TRIAL REGISTRATION: GRIT ISRCTN41358726 and TRUFFLE ISRCTN56204499. © 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.

U2 - 10.1002/uog.20354

DO - 10.1002/uog.20354

M3 - SCORING: Journal article

C2 - 31125465

VL - 55

SP - 68

EP - 74

JO - ULTRASOUND OBST GYN

JF - ULTRASOUND OBST GYN

SN - 0960-7692

IS - 1

ER -