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Common breast cancer susceptibility loci are associated with triple-negative breast cancer.

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Common breast cancer susceptibility loci are associated with triple-negative breast cancer. / Stevens, Kristen N; Vachon, Celine M; Lee, Adam M; Slager, Susan; Lesnick, Timothy; Olswold, Curtis; Fasching, Peter A; Miron, Penelope; Eccles, Diana; Carpenter, Jane E; Godwin, Andrew K; Ambrosone, Christine; Winqvist, Robert; Brauch, Hiltrud; Consortium, GENICA; Schmidt, Marjanka K; Cox, Angela; Cross, Simon S; Sawyer, Elinor; Hartmann, Arndt; Beckmann, Matthias W; Schulz-Wendtland, Rüdiger; Ekici, Arif B; Tapper, William J; Gerty, Susan M; Durcan, Lorraine; Graham, Nikki; Hein, Rebecca; Nickels, Stephan; Flesch-Janys, Dieter; Heinz, Judith; Sinn, Hans-Peter; Konstantopoulou, Irene; Fostira, Florentia; Pectasides, Dimitrios; Dimopoulos, Athanasios M; Fountzilas, George; Clarke, Christine L; Balleine, Rosemary; Olson, Janet E; Fredericksen, Zachary; Diasio, Robert B; Pathak, Harsh; Ross, Eric; Weaver, JoEllen; Rüdiger, Thomas; Försti, Asta; Dünnebier, Thomas; Ademuyiwa, Foluso; Kulkarni, Swati; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Ko, Yon-Dschun; Erik, Van Limbergen; Janssen, Hilde; Peto, Julian; Fletcher, Olivia; Giles, Graham G; Baglietto, Laura; Verhoef, Senno; Tomlinson, Ian; Kosma, Veli-Matti; Beesley, Jonathan; Greco, Dario; Blomqvist, Carl; Irwanto, Astrid; Liu, Jianjun; Blows, Fiona M; Dawson, Sarah-Jane; Margolin, Sara; Mannermaa, Arto; Martin, Nicholas G; Montgomery, Grant W; Lambrechts, Diether; Isabel, Dos Santos Silva; Severi, Gianluca; Hamann, Ute; Pharoah, Paul; Easton, Douglas F; Chang-Claude, Jenny; Yannoukakos, Drakoulis; Nevanlinna, Heli; Wang, Xianshu; Couch, Fergus J.

In: CANCER RES, Vol. 71, No. 19, 19, 2011, p. 6240-6249.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stevens, KN, Vachon, CM, Lee, AM, Slager, S, Lesnick, T, Olswold, C, Fasching, PA, Miron, P, Eccles, D, Carpenter, JE, Godwin, AK, Ambrosone, C, Winqvist, R, Brauch, H, Consortium, GENICA, Schmidt, MK, Cox, A, Cross, SS, Sawyer, E, Hartmann, A, Beckmann, MW, Schulz-Wendtland, R, Ekici, AB, Tapper, WJ, Gerty, SM, Durcan, L, Graham, N, Hein, R, Nickels, S, Flesch-Janys, D, Heinz, J, Sinn, H-P, Konstantopoulou, I, Fostira, F, Pectasides, D, Dimopoulos, AM, Fountzilas, G, Clarke, CL, Balleine, R, Olson, JE, Fredericksen, Z, Diasio, RB, Pathak, H, Ross, E, Weaver, J, Rüdiger, T, Försti, A, Dünnebier, T, Ademuyiwa, F, Kulkarni, S, Pylkäs, K, Jukkola-Vuorinen, A, Ko, Y-D, Erik, VL, Janssen, H, Peto, J, Fletcher, O, Giles, GG, Baglietto, L, Verhoef, S, Tomlinson, I, Kosma, V-M, Beesley, J, Greco, D, Blomqvist, C, Irwanto, A, Liu, J, Blows, FM, Dawson, S-J, Margolin, S, Mannermaa, A, Martin, NG, Montgomery, GW, Lambrechts, D, Isabel, DSS, Severi, G, Hamann, U, Pharoah, P, Easton, DF, Chang-Claude, J, Yannoukakos, D, Nevanlinna, H, Wang, X & Couch, FJ 2011, 'Common breast cancer susceptibility loci are associated with triple-negative breast cancer.', CANCER RES, vol. 71, no. 19, 19, pp. 6240-6249. <http://www.ncbi.nlm.nih.gov/pubmed/21844186?dopt=Citation>

APA

Stevens, K. N., Vachon, C. M., Lee, A. M., Slager, S., Lesnick, T., Olswold, C., Fasching, P. A., Miron, P., Eccles, D., Carpenter, J. E., Godwin, A. K., Ambrosone, C., Winqvist, R., Brauch, H., Consortium, GENICA., Schmidt, M. K., Cox, A., Cross, S. S., Sawyer, E., ... Couch, F. J. (2011). Common breast cancer susceptibility loci are associated with triple-negative breast cancer. CANCER RES, 71(19), 6240-6249. [19]. http://www.ncbi.nlm.nih.gov/pubmed/21844186?dopt=Citation

Vancouver

Stevens KN, Vachon CM, Lee AM, Slager S, Lesnick T, Olswold C et al. Common breast cancer susceptibility loci are associated with triple-negative breast cancer. CANCER RES. 2011;71(19):6240-6249. 19.

Bibtex

@article{6f3d364fdb5e4efe8cfa24d60ab44d3e,
title = "Common breast cancer susceptibility loci are associated with triple-negative breast cancer.",
abstract = "Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.",
keywords = "Adult, Humans, Aged, Female, Middle Aged, Young Adult, European Continental Ancestry Group, Case-Control Studies, Risk, *Genetic Predisposition to Disease, Breast Neoplasms/etiology/*genetics/metabolism, Chromosomes, Human, Pair 19/genetics, *Polymorphism, Single Nucleotide, Receptors, Estrogen/*genetics/metabolism, Receptors, Progesterone/*genetics/metabolism, Adult, Humans, Aged, Female, Middle Aged, Young Adult, European Continental Ancestry Group, Case-Control Studies, Risk, *Genetic Predisposition to Disease, Breast Neoplasms/etiology/*genetics/metabolism, Chromosomes, Human, Pair 19/genetics, *Polymorphism, Single Nucleotide, Receptors, Estrogen/*genetics/metabolism, Receptors, Progesterone/*genetics/metabolism",
author = "Stevens, {Kristen N} and Vachon, {Celine M} and Lee, {Adam M} and Susan Slager and Timothy Lesnick and Curtis Olswold and Fasching, {Peter A} and Penelope Miron and Diana Eccles and Carpenter, {Jane E} and Godwin, {Andrew K} and Christine Ambrosone and Robert Winqvist and Hiltrud Brauch and GENICA Consortium and Schmidt, {Marjanka K} and Angela Cox and Cross, {Simon S} and Elinor Sawyer and Arndt Hartmann and Beckmann, {Matthias W} and R{\"u}diger Schulz-Wendtland and Ekici, {Arif B} and Tapper, {William J} and Gerty, {Susan M} and Lorraine Durcan and Nikki Graham and Rebecca Hein and Stephan Nickels and Dieter Flesch-Janys and Judith Heinz and Hans-Peter Sinn and Irene Konstantopoulou and Florentia Fostira and Dimitrios Pectasides and Dimopoulos, {Athanasios M} and George Fountzilas and Clarke, {Christine L} and Rosemary Balleine and Olson, {Janet E} and Zachary Fredericksen and Diasio, {Robert B} and Harsh Pathak and Eric Ross and JoEllen Weaver and Thomas R{\"u}diger and Asta F{\"o}rsti and Thomas D{\"u}nnebier and Foluso Ademuyiwa and Swati Kulkarni and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Yon-Dschun Ko and Erik, {Van Limbergen} and Hilde Janssen and Julian Peto and Olivia Fletcher and Giles, {Graham G} and Laura Baglietto and Senno Verhoef and Ian Tomlinson and Veli-Matti Kosma and Jonathan Beesley and Dario Greco and Carl Blomqvist and Astrid Irwanto and Jianjun Liu and Blows, {Fiona M} and Sarah-Jane Dawson and Sara Margolin and Arto Mannermaa and Martin, {Nicholas G} and Montgomery, {Grant W} and Diether Lambrechts and Isabel, {Dos Santos Silva} and Gianluca Severi and Ute Hamann and Paul Pharoah and Easton, {Douglas F} and Jenny Chang-Claude and Drakoulis Yannoukakos and Heli Nevanlinna and Xianshu Wang and Couch, {Fergus J}",
year = "2011",
language = "English",
volume = "71",
pages = "6240--6249",
journal = "CANCER RES",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "19",

}

RIS

TY - JOUR

T1 - Common breast cancer susceptibility loci are associated with triple-negative breast cancer.

AU - Stevens, Kristen N

AU - Vachon, Celine M

AU - Lee, Adam M

AU - Slager, Susan

AU - Lesnick, Timothy

AU - Olswold, Curtis

AU - Fasching, Peter A

AU - Miron, Penelope

AU - Eccles, Diana

AU - Carpenter, Jane E

AU - Godwin, Andrew K

AU - Ambrosone, Christine

AU - Winqvist, Robert

AU - Brauch, Hiltrud

AU - Consortium, GENICA

AU - Schmidt, Marjanka K

AU - Cox, Angela

AU - Cross, Simon S

AU - Sawyer, Elinor

AU - Hartmann, Arndt

AU - Beckmann, Matthias W

AU - Schulz-Wendtland, Rüdiger

AU - Ekici, Arif B

AU - Tapper, William J

AU - Gerty, Susan M

AU - Durcan, Lorraine

AU - Graham, Nikki

AU - Hein, Rebecca

AU - Nickels, Stephan

AU - Flesch-Janys, Dieter

AU - Heinz, Judith

AU - Sinn, Hans-Peter

AU - Konstantopoulou, Irene

AU - Fostira, Florentia

AU - Pectasides, Dimitrios

AU - Dimopoulos, Athanasios M

AU - Fountzilas, George

AU - Clarke, Christine L

AU - Balleine, Rosemary

AU - Olson, Janet E

AU - Fredericksen, Zachary

AU - Diasio, Robert B

AU - Pathak, Harsh

AU - Ross, Eric

AU - Weaver, JoEllen

AU - Rüdiger, Thomas

AU - Försti, Asta

AU - Dünnebier, Thomas

AU - Ademuyiwa, Foluso

AU - Kulkarni, Swati

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Ko, Yon-Dschun

AU - Erik, Van Limbergen

AU - Janssen, Hilde

AU - Peto, Julian

AU - Fletcher, Olivia

AU - Giles, Graham G

AU - Baglietto, Laura

AU - Verhoef, Senno

AU - Tomlinson, Ian

AU - Kosma, Veli-Matti

AU - Beesley, Jonathan

AU - Greco, Dario

AU - Blomqvist, Carl

AU - Irwanto, Astrid

AU - Liu, Jianjun

AU - Blows, Fiona M

AU - Dawson, Sarah-Jane

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Martin, Nicholas G

AU - Montgomery, Grant W

AU - Lambrechts, Diether

AU - Isabel, Dos Santos Silva

AU - Severi, Gianluca

AU - Hamann, Ute

AU - Pharoah, Paul

AU - Easton, Douglas F

AU - Chang-Claude, Jenny

AU - Yannoukakos, Drakoulis

AU - Nevanlinna, Heli

AU - Wang, Xianshu

AU - Couch, Fergus J

PY - 2011

Y1 - 2011

N2 - Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.

AB - Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Young Adult

KW - European Continental Ancestry Group

KW - Case-Control Studies

KW - Risk

KW - Genetic Predisposition to Disease

KW - Breast Neoplasms/etiology/genetics/metabolism

KW - Chromosomes, Human, Pair 19/genetics

KW - Polymorphism, Single Nucleotide

KW - Receptors, Estrogen/genetics/metabolism

KW - Receptors, Progesterone/genetics/metabolism

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Young Adult

KW - European Continental Ancestry Group

KW - Case-Control Studies

KW - Risk

KW - Genetic Predisposition to Disease

KW - Breast Neoplasms/etiology/genetics/metabolism

KW - Chromosomes, Human, Pair 19/genetics

KW - Polymorphism, Single Nucleotide

KW - Receptors, Estrogen/genetics/metabolism

KW - Receptors, Progesterone/genetics/metabolism

M3 - SCORING: Journal article

VL - 71

SP - 6240

EP - 6249

JO - CANCER RES

JF - CANCER RES

SN - 0008-5472

IS - 19

M1 - 19

ER -