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Combining baseline characteristics to disentangle response differences to disorder-specific versus supportive psychotherapy in patients with persistent depressive disorder

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Combining baseline characteristics to disentangle response differences to disorder-specific versus supportive psychotherapy in patients with persistent depressive disorder. / Serbanescu, Ilinca; Walter, Henrik; Schnell, Knut; Kessler, Henrik; Weber, Bernd; Drost, Sarah; Groß, Magdalena; Neudeck, Peter; Klein, Jan Philipp; Assmann, Nele; Zobel, Ingo; Backenstrass, Matthias; Hautzinger, Martin; Meister, Ramona; Härter, Martin; Schramm, Elisabeth; Schoepf, Dieter.

In: BEHAV RES THER, Vol. 124, 01.2020, p. 103512.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Serbanescu, I, Walter, H, Schnell, K, Kessler, H, Weber, B, Drost, S, Groß, M, Neudeck, P, Klein, JP, Assmann, N, Zobel, I, Backenstrass, M, Hautzinger, M, Meister, R, Härter, M, Schramm, E & Schoepf, D 2020, 'Combining baseline characteristics to disentangle response differences to disorder-specific versus supportive psychotherapy in patients with persistent depressive disorder', BEHAV RES THER, vol. 124, pp. 103512. https://doi.org/10.1016/j.brat.2019.103512

APA

Serbanescu, I., Walter, H., Schnell, K., Kessler, H., Weber, B., Drost, S., Groß, M., Neudeck, P., Klein, J. P., Assmann, N., Zobel, I., Backenstrass, M., Hautzinger, M., Meister, R., Härter, M., Schramm, E., & Schoepf, D. (2020). Combining baseline characteristics to disentangle response differences to disorder-specific versus supportive psychotherapy in patients with persistent depressive disorder. BEHAV RES THER, 124, 103512. https://doi.org/10.1016/j.brat.2019.103512

Vancouver

Serbanescu I, Walter H, Schnell K, Kessler H, Weber B, Drost S et al. Combining baseline characteristics to disentangle response differences to disorder-specific versus supportive psychotherapy in patients with persistent depressive disorder. BEHAV RES THER. 2020 Jan;124:103512. https://doi.org/10.1016/j.brat.2019.103512

Bibtex

@article{440ee807acb342faaf5b540efce2706b,
title = "Combining baseline characteristics to disentangle response differences to disorder-specific versus supportive psychotherapy in patients with persistent depressive disorder",
abstract = "Does the pre-treatment profile of individuals with persistent depressive disorder (PDD) moderate their benefit from disorder-specific Cognitive Behavioral System of Psychotherapy (CBASP) versus supportive psychotherapy (SP)? We investigated this question by analyzing data from a multi-center randomized clinical trial comparing the effectiveness of 48 weeks of CBASP to SP in n  =  237 patients with early-onset PDD who were not taking antidepressant medication. We statistically developed an optimal composite moderator as a weighted combination of 13 preselected baseline variables and used it for identifying and characterizing subgroups for which CABSP may be preferable to SP or vice versa. We identified two distinct subgroups: 58.65% of the patients had a better treatment outcome with CBASP, while the remaining 41.35% had a better outcome with SP. At baseline, patients responding more favorably to CBASP were more severely depressed and more likely affected by moderate-to-severe childhood trauma including early emotional, physical, or sexual abuse, as well as emotional or physical neglect. In contrast, patients responding more favorably to SP had a higher pre-treatment global and social functioning level, a higher life quality and more often a recurrent illness pattern without complete remission between the episodes. These findings emphasize the relevance of considering pre-treatment characteristics when selecting between disorder-specific CBASP and SP for treating PDD. The practical implementation of this approach would advance personalized medicine for PDD by supporting mental health practitioners in their selection of the most effective psychotherapy for an individual patient.",
author = "Ilinca Serbanescu and Henrik Walter and Knut Schnell and Henrik Kessler and Bernd Weber and Sarah Drost and Magdalena Gro{\ss} and Peter Neudeck and Klein, {Jan Philipp} and Nele Assmann and Ingo Zobel and Matthias Backenstrass and Martin Hautzinger and Ramona Meister and Martin H{\"a}rter and Elisabeth Schramm and Dieter Schoepf",
note = "Copyright {\textcopyright} 2019 Elsevier Ltd. All rights reserved.",
year = "2020",
month = jan,
doi = "10.1016/j.brat.2019.103512",
language = "English",
volume = "124",
pages = "103512",
journal = "BEHAV RES THER",
issn = "0005-7967",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Combining baseline characteristics to disentangle response differences to disorder-specific versus supportive psychotherapy in patients with persistent depressive disorder

AU - Serbanescu, Ilinca

AU - Walter, Henrik

AU - Schnell, Knut

AU - Kessler, Henrik

AU - Weber, Bernd

AU - Drost, Sarah

AU - Groß, Magdalena

AU - Neudeck, Peter

AU - Klein, Jan Philipp

AU - Assmann, Nele

AU - Zobel, Ingo

AU - Backenstrass, Matthias

AU - Hautzinger, Martin

AU - Meister, Ramona

AU - Härter, Martin

AU - Schramm, Elisabeth

AU - Schoepf, Dieter

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2020/1

Y1 - 2020/1

N2 - Does the pre-treatment profile of individuals with persistent depressive disorder (PDD) moderate their benefit from disorder-specific Cognitive Behavioral System of Psychotherapy (CBASP) versus supportive psychotherapy (SP)? We investigated this question by analyzing data from a multi-center randomized clinical trial comparing the effectiveness of 48 weeks of CBASP to SP in n  =  237 patients with early-onset PDD who were not taking antidepressant medication. We statistically developed an optimal composite moderator as a weighted combination of 13 preselected baseline variables and used it for identifying and characterizing subgroups for which CABSP may be preferable to SP or vice versa. We identified two distinct subgroups: 58.65% of the patients had a better treatment outcome with CBASP, while the remaining 41.35% had a better outcome with SP. At baseline, patients responding more favorably to CBASP were more severely depressed and more likely affected by moderate-to-severe childhood trauma including early emotional, physical, or sexual abuse, as well as emotional or physical neglect. In contrast, patients responding more favorably to SP had a higher pre-treatment global and social functioning level, a higher life quality and more often a recurrent illness pattern without complete remission between the episodes. These findings emphasize the relevance of considering pre-treatment characteristics when selecting between disorder-specific CBASP and SP for treating PDD. The practical implementation of this approach would advance personalized medicine for PDD by supporting mental health practitioners in their selection of the most effective psychotherapy for an individual patient.

AB - Does the pre-treatment profile of individuals with persistent depressive disorder (PDD) moderate their benefit from disorder-specific Cognitive Behavioral System of Psychotherapy (CBASP) versus supportive psychotherapy (SP)? We investigated this question by analyzing data from a multi-center randomized clinical trial comparing the effectiveness of 48 weeks of CBASP to SP in n  =  237 patients with early-onset PDD who were not taking antidepressant medication. We statistically developed an optimal composite moderator as a weighted combination of 13 preselected baseline variables and used it for identifying and characterizing subgroups for which CABSP may be preferable to SP or vice versa. We identified two distinct subgroups: 58.65% of the patients had a better treatment outcome with CBASP, while the remaining 41.35% had a better outcome with SP. At baseline, patients responding more favorably to CBASP were more severely depressed and more likely affected by moderate-to-severe childhood trauma including early emotional, physical, or sexual abuse, as well as emotional or physical neglect. In contrast, patients responding more favorably to SP had a higher pre-treatment global and social functioning level, a higher life quality and more often a recurrent illness pattern without complete remission between the episodes. These findings emphasize the relevance of considering pre-treatment characteristics when selecting between disorder-specific CBASP and SP for treating PDD. The practical implementation of this approach would advance personalized medicine for PDD by supporting mental health practitioners in their selection of the most effective psychotherapy for an individual patient.

U2 - 10.1016/j.brat.2019.103512

DO - 10.1016/j.brat.2019.103512

M3 - SCORING: Journal article

C2 - 31734568

VL - 124

SP - 103512

JO - BEHAV RES THER

JF - BEHAV RES THER

SN - 0005-7967

ER -