Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses
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Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses. / Li, Shuo; Raychaudhuri, Sumana; Lee, Stephen Alexander; Brockmann, Marisa M.; Wang, Jing; Kusick, Grant; Prater, Christine; Syed, Sarah; Falahati, Hanieh; Ramos, Raul; Bartol, Tomas M.; Hosy, Eric; Watanabe, Shigeki.
In: NAT COMMUN, Vol. 12, No. 1, 29.01.2021, p. 677.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses
AU - Li, Shuo
AU - Raychaudhuri, Sumana
AU - Lee, Stephen Alexander
AU - Brockmann, Marisa M.
AU - Wang, Jing
AU - Kusick, Grant
AU - Prater, Christine
AU - Syed, Sarah
AU - Falahati, Hanieh
AU - Ramos, Raul
AU - Bartol, Tomas M.
AU - Hosy, Eric
AU - Watanabe, Shigeki
PY - 2021/1/29
Y1 - 2021/1/29
N2 - Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous release sites enriched near the center in mouse hippocampal synapses. Here we demonstrate that synchronous and asynchronous release sites are aligned with AMPA receptor and NMDA receptor clusters, respectively. Computational simulations indicate that this spatial and temporal arrangement of release can lead to maximal membrane depolarization through AMPA receptors, alleviating the pore-blocking magnesium leading to greater activation of NMDA receptors. Together, these results suggest that release sites are likely organized to activate NMDA receptors efficiently.
AB - Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous release sites enriched near the center in mouse hippocampal synapses. Here we demonstrate that synchronous and asynchronous release sites are aligned with AMPA receptor and NMDA receptor clusters, respectively. Computational simulations indicate that this spatial and temporal arrangement of release can lead to maximal membrane depolarization through AMPA receptors, alleviating the pore-blocking magnesium leading to greater activation of NMDA receptors. Together, these results suggest that release sites are likely organized to activate NMDA receptors efficiently.
U2 - 10.1038/s41467-021-21004-x
DO - 10.1038/s41467-021-21004-x
M3 - SCORING: Journal article
VL - 12
SP - 677
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
IS - 1
ER -