Application and limitations of transient liver elastography in children
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Application and limitations of transient liver elastography in children. / Goldschmidt, Imeke; Streckenbach, Carolin; Dingemann, Carmen; Pfister, Eva Doreen; di Nanni, André; Zapf, Antonia; Baumann, Ulrich.
In: J PEDIATR GASTR NUTR, Vol. 57, No. 1, 07.2013, p. 109-113.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Application and limitations of transient liver elastography in children
AU - Goldschmidt, Imeke
AU - Streckenbach, Carolin
AU - Dingemann, Carmen
AU - Pfister, Eva Doreen
AU - di Nanni, André
AU - Zapf, Antonia
AU - Baumann, Ulrich
PY - 2013/7
Y1 - 2013/7
N2 - OBJECTIVES: Transient elastography (TE) using the FibroScan has gained popularity recently for the noninvasive diagnosis of hepatic fibrosis. Data on its use in children younger than 6 years are still scarce, and the influence of technical aspects such as probe choice and site of measurement on FibroScan results is not clear. Our study aims to clarify some technical issues concerning the use of the FibroScan in children and to deliver normal FibroScan values for reference.METHODS: TE was performed in 527 children (229 girls, ages 0.1-17.8 [median 6.0] years, including 400 healthy controls). Feasibility of different sites of measurements, paired comparison of probe settings, and pre- and postprandial measurements were systematically performed. Sedated versus unsedated measurements were compared in age- and sex-matched cohorts.RESULTS: Success rate of TE in our population was 90%, but decreased to 83% in children younger than 24 months even in ideal conditions. General anesthesia significantly increased liver stiffness in healthy children (5.4 [3-9.5] vs 4.2 [2.8-8.15] kPa; P < 0.01). Probe choice equally influenced results in paired comparisons (S1 5.5 [3.5-17.9] vs S2 4.8 [2.1-15.4] kPa; P < 0.01), as did food intake (5.9 [3.6-75] vs 5.4 [3.6-63.9] kPa; P = 0.015). Inter- and intraobserver agreements were good. Normal liver stiffness was 4.5 (2.5-8.9) kPa and did not vary significantly with age or sex.CONCLUSIONS: TE is feasible even in extremely young children, but confounding influences on test results such as probe choice, sedation, or food intake need to be taken into account when interpreting results.
AB - OBJECTIVES: Transient elastography (TE) using the FibroScan has gained popularity recently for the noninvasive diagnosis of hepatic fibrosis. Data on its use in children younger than 6 years are still scarce, and the influence of technical aspects such as probe choice and site of measurement on FibroScan results is not clear. Our study aims to clarify some technical issues concerning the use of the FibroScan in children and to deliver normal FibroScan values for reference.METHODS: TE was performed in 527 children (229 girls, ages 0.1-17.8 [median 6.0] years, including 400 healthy controls). Feasibility of different sites of measurements, paired comparison of probe settings, and pre- and postprandial measurements were systematically performed. Sedated versus unsedated measurements were compared in age- and sex-matched cohorts.RESULTS: Success rate of TE in our population was 90%, but decreased to 83% in children younger than 24 months even in ideal conditions. General anesthesia significantly increased liver stiffness in healthy children (5.4 [3-9.5] vs 4.2 [2.8-8.15] kPa; P < 0.01). Probe choice equally influenced results in paired comparisons (S1 5.5 [3.5-17.9] vs S2 4.8 [2.1-15.4] kPa; P < 0.01), as did food intake (5.9 [3.6-75] vs 5.4 [3.6-63.9] kPa; P = 0.015). Inter- and intraobserver agreements were good. Normal liver stiffness was 4.5 (2.5-8.9) kPa and did not vary significantly with age or sex.CONCLUSIONS: TE is feasible even in extremely young children, but confounding influences on test results such as probe choice, sedation, or food intake need to be taken into account when interpreting results.
KW - Age Factors
KW - Anesthesia, General
KW - Child
KW - Child, Preschool
KW - Cohort Studies
KW - Elasticity Imaging Techniques
KW - Fasting
KW - Feasibility Studies
KW - Female
KW - Humans
KW - Infant
KW - Liver
KW - Liver Cirrhosis
KW - Liver Diseases
KW - Male
KW - Postprandial Period
KW - Practice Guidelines as Topic
KW - Reference Values
KW - Reproducibility of Results
KW - Comparative Study
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1097/MPG.0b013e31829206a0
DO - 10.1097/MPG.0b013e31829206a0
M3 - SCORING: Journal article
C2 - 23539048
VL - 57
SP - 109
EP - 113
JO - J PEDIATR GASTR NUTR
JF - J PEDIATR GASTR NUTR
SN - 0277-2116
IS - 1
ER -