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APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease

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APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease. / Morgen, Katrin; Frölich, Lutz; Tost, Heike; Plichta, Michael M; Kölsch, Heike; Rakebrandt, Fabian; Rienhoff, Otto; Jessen, Frank; Peters, Oliver; Jahn, Holger; Luckhaus, Christian; Hüll, Michael; Gertz, Hermann-Josef; Schröder, Johannes; Hampel, Harald; Teipel, Stefan J; Pantel, Johannes; Heuser, Isabella; Wiltfang, Jens; Rüther, Eckart; Kornhuber, Johannes; Maier, Wolfgang; Meyer-Lindenberg, Andreas.

In: J ALZHEIMERS DIS, Vol. 37, No. 2, 01.01.2013, p. 389-401.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Morgen, K, Frölich, L, Tost, H, Plichta, MM, Kölsch, H, Rakebrandt, F, Rienhoff, O, Jessen, F, Peters, O, Jahn, H, Luckhaus, C, Hüll, M, Gertz, H-J, Schröder, J, Hampel, H, Teipel, SJ, Pantel, J, Heuser, I, Wiltfang, J, Rüther, E, Kornhuber, J, Maier, W & Meyer-Lindenberg, A 2013, 'APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease', J ALZHEIMERS DIS, vol. 37, no. 2, pp. 389-401. https://doi.org/10.3233/JAD-130326

APA

Morgen, K., Frölich, L., Tost, H., Plichta, M. M., Kölsch, H., Rakebrandt, F., Rienhoff, O., Jessen, F., Peters, O., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H-J., Schröder, J., Hampel, H., Teipel, S. J., Pantel, J., Heuser, I., Wiltfang, J., ... Meyer-Lindenberg, A. (2013). APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease. J ALZHEIMERS DIS, 37(2), 389-401. https://doi.org/10.3233/JAD-130326

Vancouver

Morgen K, Frölich L, Tost H, Plichta MM, Kölsch H, Rakebrandt F et al. APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease. J ALZHEIMERS DIS. 2013 Jan 1;37(2):389-401. https://doi.org/10.3233/JAD-130326

Bibtex

@article{d9d6aa7769ea45e2a347edb435784016,
title = "APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease",
abstract = "BACKGROUND: The E4 isoform of the APOE genotype is the most significant genetic risk factor for sporadic Alzheimer's disease (AD) and has recently been found to modulate disease expression in patients with AD.OBJECTIVE: To investigate APOE-dependent cognitive and structural phenotypes in subjects with mild cognitive impairment who converted to AD within the following three years.METHODS: Subjects converting to AD (n = 63) were compared to a control group with stable mild cognitive impairment (n = 131). Clinical, neuropsychological, and MRI data were obtained by the German Dementia Competence Network. Subgroups of converting and stable APOE E4 carriers and non-carriers were investigated longitudinally with MRI to examine structural correlates of conversion. Voxel-based morphometry was applied to investigate gray matter distribution.RESULTS: At baseline, executive performance correlated with global and bilateral prefrontal gray matter volume and predicted conversion only among non-carriers. Converting carriers and non-carriers presented distinct patterns of brain atrophy on longitudinal analysis, in line with a dissociation between more pronounced occipital atrophy in carriers and more frontoparietal volume loss in non-carriers at follow-up.CONCLUSIONS: The current findings suggest that in APOE E4 non-carriers with AD, executive dysfunction is closely linked to frontal gray matter atrophy and predictive of progression to dementia. The results are consistent with APOE genotype-dependent profiles of structural damage and cognitive decline in patients with imminent conversion to AD.",
keywords = "Alzheimer Disease, Apolipoproteins E, Atrophy, Cross-Sectional Studies, Disease Progression, Executive Function, Female, Genotype, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mild Cognitive Impairment, Neuropsychological Tests, Phenotype, Protein Isoforms, Statistics as Topic",
author = "Katrin Morgen and Lutz Fr{\"o}lich and Heike Tost and Plichta, {Michael M} and Heike K{\"o}lsch and Fabian Rakebrandt and Otto Rienhoff and Frank Jessen and Oliver Peters and Holger Jahn and Christian Luckhaus and Michael H{\"u}ll and Hermann-Josef Gertz and Johannes Schr{\"o}der and Harald Hampel and Teipel, {Stefan J} and Johannes Pantel and Isabella Heuser and Jens Wiltfang and Eckart R{\"u}ther and Johannes Kornhuber and Wolfgang Maier and Andreas Meyer-Lindenberg",
year = "2013",
month = jan,
day = "1",
doi = "10.3233/JAD-130326",
language = "English",
volume = "37",
pages = "389--401",
journal = "J ALZHEIMERS DIS",
issn = "1387-2877",
publisher = "IOS Press",
number = "2",

}

RIS

TY - JOUR

T1 - APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease

AU - Morgen, Katrin

AU - Frölich, Lutz

AU - Tost, Heike

AU - Plichta, Michael M

AU - Kölsch, Heike

AU - Rakebrandt, Fabian

AU - Rienhoff, Otto

AU - Jessen, Frank

AU - Peters, Oliver

AU - Jahn, Holger

AU - Luckhaus, Christian

AU - Hüll, Michael

AU - Gertz, Hermann-Josef

AU - Schröder, Johannes

AU - Hampel, Harald

AU - Teipel, Stefan J

AU - Pantel, Johannes

AU - Heuser, Isabella

AU - Wiltfang, Jens

AU - Rüther, Eckart

AU - Kornhuber, Johannes

AU - Maier, Wolfgang

AU - Meyer-Lindenberg, Andreas

PY - 2013/1/1

Y1 - 2013/1/1

N2 - BACKGROUND: The E4 isoform of the APOE genotype is the most significant genetic risk factor for sporadic Alzheimer's disease (AD) and has recently been found to modulate disease expression in patients with AD.OBJECTIVE: To investigate APOE-dependent cognitive and structural phenotypes in subjects with mild cognitive impairment who converted to AD within the following three years.METHODS: Subjects converting to AD (n = 63) were compared to a control group with stable mild cognitive impairment (n = 131). Clinical, neuropsychological, and MRI data were obtained by the German Dementia Competence Network. Subgroups of converting and stable APOE E4 carriers and non-carriers were investigated longitudinally with MRI to examine structural correlates of conversion. Voxel-based morphometry was applied to investigate gray matter distribution.RESULTS: At baseline, executive performance correlated with global and bilateral prefrontal gray matter volume and predicted conversion only among non-carriers. Converting carriers and non-carriers presented distinct patterns of brain atrophy on longitudinal analysis, in line with a dissociation between more pronounced occipital atrophy in carriers and more frontoparietal volume loss in non-carriers at follow-up.CONCLUSIONS: The current findings suggest that in APOE E4 non-carriers with AD, executive dysfunction is closely linked to frontal gray matter atrophy and predictive of progression to dementia. The results are consistent with APOE genotype-dependent profiles of structural damage and cognitive decline in patients with imminent conversion to AD.

AB - BACKGROUND: The E4 isoform of the APOE genotype is the most significant genetic risk factor for sporadic Alzheimer's disease (AD) and has recently been found to modulate disease expression in patients with AD.OBJECTIVE: To investigate APOE-dependent cognitive and structural phenotypes in subjects with mild cognitive impairment who converted to AD within the following three years.METHODS: Subjects converting to AD (n = 63) were compared to a control group with stable mild cognitive impairment (n = 131). Clinical, neuropsychological, and MRI data were obtained by the German Dementia Competence Network. Subgroups of converting and stable APOE E4 carriers and non-carriers were investigated longitudinally with MRI to examine structural correlates of conversion. Voxel-based morphometry was applied to investigate gray matter distribution.RESULTS: At baseline, executive performance correlated with global and bilateral prefrontal gray matter volume and predicted conversion only among non-carriers. Converting carriers and non-carriers presented distinct patterns of brain atrophy on longitudinal analysis, in line with a dissociation between more pronounced occipital atrophy in carriers and more frontoparietal volume loss in non-carriers at follow-up.CONCLUSIONS: The current findings suggest that in APOE E4 non-carriers with AD, executive dysfunction is closely linked to frontal gray matter atrophy and predictive of progression to dementia. The results are consistent with APOE genotype-dependent profiles of structural damage and cognitive decline in patients with imminent conversion to AD.

KW - Alzheimer Disease

KW - Apolipoproteins E

KW - Atrophy

KW - Cross-Sectional Studies

KW - Disease Progression

KW - Executive Function

KW - Female

KW - Genotype

KW - Humans

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging

KW - Male

KW - Mild Cognitive Impairment

KW - Neuropsychological Tests

KW - Phenotype

KW - Protein Isoforms

KW - Statistics as Topic

U2 - 10.3233/JAD-130326

DO - 10.3233/JAD-130326

M3 - SCORING: Journal article

C2 - 23948881

VL - 37

SP - 389

EP - 401

JO - J ALZHEIMERS DIS

JF - J ALZHEIMERS DIS

SN - 1387-2877

IS - 2

ER -