Altered microstructure of the contralesional ventral premotor cortex and motor output after stroke
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Altered microstructure of the contralesional ventral premotor cortex and motor output after stroke. / Wróbel, Paweł P; Guder, Stephanie; Feldheim, Jan F; Graterol Pérez, José A; Frey, Benedikt M; Choe, Chi-Un; Bönstrup, Marlene; Cheng, Bastian; Rathi, Yogesh; Pasternak, Ofer; Thomalla, Götz; Gerloff, Christian; Shenton, Martha E; Schulz, Robert.
In: BRAIN COMMUN, Vol. 5, No. 3, fcad160, 2023.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Altered microstructure of the contralesional ventral premotor cortex and motor output after stroke
AU - Wróbel, Paweł P
AU - Guder, Stephanie
AU - Feldheim, Jan F
AU - Graterol Pérez, José A
AU - Frey, Benedikt M
AU - Choe, Chi-Un
AU - Bönstrup, Marlene
AU - Cheng, Bastian
AU - Rathi, Yogesh
AU - Pasternak, Ofer
AU - Thomalla, Götz
AU - Gerloff, Christian
AU - Shenton, Martha E
AU - Schulz, Robert
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.
PY - 2023
Y1 - 2023
N2 - Cortical thickness analyses have provided valuable insights into changes in cortical brain structure after stroke and their association with recovery. Across studies though, relationships between cortical structure and function show inconsistent results. Recent developments in diffusion-weighted imaging of the cortex have paved the way to uncover hidden aspects of stroke-related alterations in cortical microstructure, going beyond cortical thickness as a surrogate for cortical macrostructure. We re-analysed clinical and imaging data of 42 well-recovered chronic stroke patients from 2 independent cohorts (mean age 64 years, 4 left-handed, 71% male, 16 right-sided strokes) and 33 healthy controls of similar age and gender. Cortical fractional anisotropy and cortical thickness values were obtained for six key sensorimotor areas of the contralesional hemisphere. The regions included the primary motor cortex, dorsal and ventral premotor cortex, supplementary and pre-supplementary motor areas, and primary somatosensory cortex. Linear models were estimated for group comparisons between patients and controls and for correlations between cortical fractional anisotropy and cortical thickness and clinical scores. Compared with controls, stroke patients exhibited a reduction in fractional anisotropy in the contralesional ventral premotor cortex (P = 0.005). Fractional anisotropy of the other regions and cortical thickness did not show a comparable group difference. Higher fractional anisotropy of the ventral premotor cortex, but not cortical thickness, was positively associated with residual grip force in the stroke patients. These data provide novel evidence that the contralesional ventral premotor cortex might constitute a key sensorimotor area particularly susceptible to stroke-related alterations in cortical microstructure as measured by diffusion MRI and they suggest a link between these changes and residual motor output after stroke.
AB - Cortical thickness analyses have provided valuable insights into changes in cortical brain structure after stroke and their association with recovery. Across studies though, relationships between cortical structure and function show inconsistent results. Recent developments in diffusion-weighted imaging of the cortex have paved the way to uncover hidden aspects of stroke-related alterations in cortical microstructure, going beyond cortical thickness as a surrogate for cortical macrostructure. We re-analysed clinical and imaging data of 42 well-recovered chronic stroke patients from 2 independent cohorts (mean age 64 years, 4 left-handed, 71% male, 16 right-sided strokes) and 33 healthy controls of similar age and gender. Cortical fractional anisotropy and cortical thickness values were obtained for six key sensorimotor areas of the contralesional hemisphere. The regions included the primary motor cortex, dorsal and ventral premotor cortex, supplementary and pre-supplementary motor areas, and primary somatosensory cortex. Linear models were estimated for group comparisons between patients and controls and for correlations between cortical fractional anisotropy and cortical thickness and clinical scores. Compared with controls, stroke patients exhibited a reduction in fractional anisotropy in the contralesional ventral premotor cortex (P = 0.005). Fractional anisotropy of the other regions and cortical thickness did not show a comparable group difference. Higher fractional anisotropy of the ventral premotor cortex, but not cortical thickness, was positively associated with residual grip force in the stroke patients. These data provide novel evidence that the contralesional ventral premotor cortex might constitute a key sensorimotor area particularly susceptible to stroke-related alterations in cortical microstructure as measured by diffusion MRI and they suggest a link between these changes and residual motor output after stroke.
U2 - 10.1093/braincomms/fcad160
DO - 10.1093/braincomms/fcad160
M3 - SCORING: Journal article
C2 - 37265601
VL - 5
JO - BRAIN COMMUN
JF - BRAIN COMMUN
SN - 2632-1297
IS - 3
M1 - fcad160
ER -
