Adenylylation
Standard
Adenylylation : renaissance of a forgotten post-translational modification. / Itzen, Aymelt; Blankenfeldt, Wulf; Goody, Roger S.
In: TRENDS BIOCHEM SCI, Vol. 36, No. 4, 04.2011, p. 221-8.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Adenylylation
T2 - renaissance of a forgotten post-translational modification
AU - Itzen, Aymelt
AU - Blankenfeldt, Wulf
AU - Goody, Roger S
N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.
PY - 2011/4
Y1 - 2011/4
N2 - The stable post-translational modification of proteins by adenylylation or uridylylation was discovered more than four decades ago as a mechanism to regulate the activity of enzymes. Although many other processes involving the covalent transfer of an AMP residue to an amino acid side chain have been identified since then, these are transient adenylylation events that essentially use the free energy of ATP hydrolysis to activate specific processes. Recently, new examples of stable adenylylation of small GTPases involved in signal transduction and regulation of cellular events were discovered, which appear to modulate downstream processes such as cytoskeletal rearrangement and vesicular trafficking. We present a survey of the historical and modern phases of research in this area, focusing on the common and differing aspects of protein adenylylation.
AB - The stable post-translational modification of proteins by adenylylation or uridylylation was discovered more than four decades ago as a mechanism to regulate the activity of enzymes. Although many other processes involving the covalent transfer of an AMP residue to an amino acid side chain have been identified since then, these are transient adenylylation events that essentially use the free energy of ATP hydrolysis to activate specific processes. Recently, new examples of stable adenylylation of small GTPases involved in signal transduction and regulation of cellular events were discovered, which appear to modulate downstream processes such as cytoskeletal rearrangement and vesicular trafficking. We present a survey of the historical and modern phases of research in this area, focusing on the common and differing aspects of protein adenylylation.
KW - Adenine
KW - Adenosine Monophosphate
KW - Animals
KW - Glutamate Synthase
KW - Humans
KW - Protein Processing, Post-Translational
KW - Proteins
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1016/j.tibs.2010.12.004
DO - 10.1016/j.tibs.2010.12.004
M3 - SCORING: Review article
C2 - 21256032
VL - 36
SP - 221
EP - 228
JO - TRENDS BIOCHEM SCI
JF - TRENDS BIOCHEM SCI
SN - 0968-0004
IS - 4
ER -