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A critical assessment of the value of lymph node dissection at radical prostatectomy: A population-based study.

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A critical assessment of the value of lymph node dissection at radical prostatectomy: A population-based study. / Abdollah, Firas; Schmitges, Jan; Sun, Maxine; Tian, Zhe; Briganti, Alberto; Shariat, Shahrokh F; Perrotte, Paul; Montorsi, Francesco; Karakiewicz, Pierre I.

In: PROSTATE, Vol. 71, No. 14, 14, 2011, p. 1587-1594.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Abdollah, F, Schmitges, J, Sun, M, Tian, Z, Briganti, A, Shariat, SF, Perrotte, P, Montorsi, F & Karakiewicz, PI 2011, 'A critical assessment of the value of lymph node dissection at radical prostatectomy: A population-based study.', PROSTATE, vol. 71, no. 14, 14, pp. 1587-1594. <http://www.ncbi.nlm.nih.gov/pubmed/21480307?dopt=Citation>

APA

Abdollah, F., Schmitges, J., Sun, M., Tian, Z., Briganti, A., Shariat, S. F., Perrotte, P., Montorsi, F., & Karakiewicz, P. I. (2011). A critical assessment of the value of lymph node dissection at radical prostatectomy: A population-based study. PROSTATE, 71(14), 1587-1594. [14]. http://www.ncbi.nlm.nih.gov/pubmed/21480307?dopt=Citation

Vancouver

Abdollah F, Schmitges J, Sun M, Tian Z, Briganti A, Shariat SF et al. A critical assessment of the value of lymph node dissection at radical prostatectomy: A population-based study. PROSTATE. 2011;71(14):1587-1594. 14.

Bibtex

@article{1f1cf53e1c7844e7ba7c4591c31f1a10,
title = "A critical assessment of the value of lymph node dissection at radical prostatectomy: A population-based study.",
abstract = "OBJECTIVE: We tested relationship between pelvic lymph node dissection (PLND) status at the time of radical prostatectomy (RP) and survival in prostate cancer (PCa) patients. METHODS: Overall, 127,824 PCa patients treated with RP between 1988 and 2006 were included. Univariable and multivariable Cox regression analyses were used to evaluate the impact of PLND status (pN0 vs. pNx vs. pN1) on cancer-specific mortality (CSM) and overall mortality (OM) rates. RESULTS: In pT2 patients, the 5-, 10-, and 15-year CSM rates were: 0.4%, 1.7%, and 3.9% for pN0, 0.6%, 2.5%, and 4.7% for pNx, 2.7%, 11.9%, and 20.6% for pN1 patients (all P??0.05). CONCLUSIONS: Patients with localized PCa treated with RP without a PLND (pNx) have less favorable survival rate than their counterparts that do not harbor lymph node invasion at PLND. However, the difference is modest (0.8% at 10 years). In consequence, the related costs and benefits of this procedure should be weighted carefully. In addition, the survival benefit of PLND was not observed in locally advanced PCa patients. Prostate {\textcopyright} 2011 Wiley-Liss, Inc.",
author = "Firas Abdollah and Jan Schmitges and Maxine Sun and Zhe Tian and Alberto Briganti and Shariat, {Shahrokh F} and Paul Perrotte and Francesco Montorsi and Karakiewicz, {Pierre I}",
year = "2011",
language = "English",
volume = "71",
pages = "1587--1594",
journal = "PROSTATE",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "14",

}

RIS

TY - JOUR

T1 - A critical assessment of the value of lymph node dissection at radical prostatectomy: A population-based study.

AU - Abdollah, Firas

AU - Schmitges, Jan

AU - Sun, Maxine

AU - Tian, Zhe

AU - Briganti, Alberto

AU - Shariat, Shahrokh F

AU - Perrotte, Paul

AU - Montorsi, Francesco

AU - Karakiewicz, Pierre I

PY - 2011

Y1 - 2011

N2 - OBJECTIVE: We tested relationship between pelvic lymph node dissection (PLND) status at the time of radical prostatectomy (RP) and survival in prostate cancer (PCa) patients. METHODS: Overall, 127,824 PCa patients treated with RP between 1988 and 2006 were included. Univariable and multivariable Cox regression analyses were used to evaluate the impact of PLND status (pN0 vs. pNx vs. pN1) on cancer-specific mortality (CSM) and overall mortality (OM) rates. RESULTS: In pT2 patients, the 5-, 10-, and 15-year CSM rates were: 0.4%, 1.7%, and 3.9% for pN0, 0.6%, 2.5%, and 4.7% for pNx, 2.7%, 11.9%, and 20.6% for pN1 patients (all P??0.05). CONCLUSIONS: Patients with localized PCa treated with RP without a PLND (pNx) have less favorable survival rate than their counterparts that do not harbor lymph node invasion at PLND. However, the difference is modest (0.8% at 10 years). In consequence, the related costs and benefits of this procedure should be weighted carefully. In addition, the survival benefit of PLND was not observed in locally advanced PCa patients. Prostate © 2011 Wiley-Liss, Inc.

AB - OBJECTIVE: We tested relationship between pelvic lymph node dissection (PLND) status at the time of radical prostatectomy (RP) and survival in prostate cancer (PCa) patients. METHODS: Overall, 127,824 PCa patients treated with RP between 1988 and 2006 were included. Univariable and multivariable Cox regression analyses were used to evaluate the impact of PLND status (pN0 vs. pNx vs. pN1) on cancer-specific mortality (CSM) and overall mortality (OM) rates. RESULTS: In pT2 patients, the 5-, 10-, and 15-year CSM rates were: 0.4%, 1.7%, and 3.9% for pN0, 0.6%, 2.5%, and 4.7% for pNx, 2.7%, 11.9%, and 20.6% for pN1 patients (all P??0.05). CONCLUSIONS: Patients with localized PCa treated with RP without a PLND (pNx) have less favorable survival rate than their counterparts that do not harbor lymph node invasion at PLND. However, the difference is modest (0.8% at 10 years). In consequence, the related costs and benefits of this procedure should be weighted carefully. In addition, the survival benefit of PLND was not observed in locally advanced PCa patients. Prostate © 2011 Wiley-Liss, Inc.

M3 - SCORING: Journal article

VL - 71

SP - 1587

EP - 1594

JO - PROSTATE

JF - PROSTATE

SN - 0270-4137

IS - 14

M1 - 14

ER -