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A comparative study of perfusion CT and 99m Tc-HMPAO SPECT measurement to assess cerebrovascular reserve capacity in patients with internal carotid artery occlusion

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A comparative study of perfusion CT and 99m Tc-HMPAO SPECT measurement to assess cerebrovascular reserve capacity in patients with internal carotid artery occlusion. / Eicker, Sven O; Turowski, B; Heiroth, H-J; Steiger, H-J; Hänggi, D.

In: EUR J MED RES, Vol. 16, No. 11, 10.11.2011, p. 484-90.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Eicker, SO, Turowski, B, Heiroth, H-J, Steiger, H-J & Hänggi, D 2011, 'A comparative study of perfusion CT and 99m Tc-HMPAO SPECT measurement to assess cerebrovascular reserve capacity in patients with internal carotid artery occlusion', EUR J MED RES, vol. 16, no. 11, pp. 484-90.

APA

Eicker, S. O., Turowski, B., Heiroth, H-J., Steiger, H-J., & Hänggi, D. (2011). A comparative study of perfusion CT and 99m Tc-HMPAO SPECT measurement to assess cerebrovascular reserve capacity in patients with internal carotid artery occlusion. EUR J MED RES, 16(11), 484-90.

Vancouver

Eicker SO, Turowski B, Heiroth H-J, Steiger H-J, Hänggi D. A comparative study of perfusion CT and 99m Tc-HMPAO SPECT measurement to assess cerebrovascular reserve capacity in patients with internal carotid artery occlusion. EUR J MED RES. 2011 Nov 10;16(11):484-90.

Bibtex

@article{06f8cb2e370f467a947d38ebd6cb9867,
title = "A comparative study of perfusion CT and 99m Tc-HMPAO SPECT measurement to assess cerebrovascular reserve capacity in patients with internal carotid artery occlusion",
abstract = "BACKGROUND AND PURPOSE: Patients with internal carotid artery (ICA) occlusion can demonstrate impaired cerebral vascular reserve (CVR). The detection of CVR using single photon emission CT (SPECT) is nowadays widely accepted as a predictor in the diagnostic pathway in patients considered for cerebral revascularization. Recently perfusion CT (PCT) gained widely acceptance in stroke imaging. The present study was aimed at comparing the results of perfusion CT (PCT) and 99m Tc-HMPAO SPECT with acetazolamide challenge in patients with ICA occlusion.METHODS: 13 patients were included in the prospective evaluation. Both PCT and 99m Tc-HMPAO SPECT were performed before and after the administration of acetazolamide. In detail, regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), adapted time to peak (Tmax) and mean transit times (MTT) were compared with SPECT data. -RESULTS: 99m Tc-HMPAO SPECT demonstrated an impairment of CVR in six patients. A preserved CVR was present in seven patients. All patients with impaired CVR proven by SPECT had a delayed MTT (mean +2.98 s) and a delayed Tmax (mean + 5.9 s), (both p <0.005 compared with the non occluded side). 66% of patients with impaired CVR in SPECT showed a complete correlation of Tmax measurements in PCT with a high positive predictive value (PPV: 88.8%). -CONCLUSION: The prospective study demonstrated a highly significant correlation of perfusion parameters as detected by 99m Tc-HMPAO SPECT and the Tmax as detected by PCT in patients with ICA occlusion. Therefore this easy-to-perform technique seems to be an adequate method for the evaluation of cerebral perfusion in patients with ICA occlusion.",
keywords = "Adolescent, Adult, Aged, Arterial Occlusive Diseases, Blood Volume, Brain Mapping, Carotid Artery, Internal, Cerebrovascular Circulation, Female, Humans, Male, Middle Aged, Perfusion, Regional Blood Flow, Technetium Tc 99m Exametazime, Time Factors, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed, Young Adult",
author = "Eicker, {Sven O} and B Turowski and H-J Heiroth and H-J Steiger and D H{\"a}nggi",
year = "2011",
month = nov,
day = "10",
language = "English",
volume = "16",
pages = "484--90",
journal = "EUR J MED RES",
issn = "0949-2321",
publisher = "BioMed Central Ltd.",
number = "11",

}

RIS

TY - JOUR

T1 - A comparative study of perfusion CT and 99m Tc-HMPAO SPECT measurement to assess cerebrovascular reserve capacity in patients with internal carotid artery occlusion

AU - Eicker, Sven O

AU - Turowski, B

AU - Heiroth, H-J

AU - Steiger, H-J

AU - Hänggi, D

PY - 2011/11/10

Y1 - 2011/11/10

N2 - BACKGROUND AND PURPOSE: Patients with internal carotid artery (ICA) occlusion can demonstrate impaired cerebral vascular reserve (CVR). The detection of CVR using single photon emission CT (SPECT) is nowadays widely accepted as a predictor in the diagnostic pathway in patients considered for cerebral revascularization. Recently perfusion CT (PCT) gained widely acceptance in stroke imaging. The present study was aimed at comparing the results of perfusion CT (PCT) and 99m Tc-HMPAO SPECT with acetazolamide challenge in patients with ICA occlusion.METHODS: 13 patients were included in the prospective evaluation. Both PCT and 99m Tc-HMPAO SPECT were performed before and after the administration of acetazolamide. In detail, regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), adapted time to peak (Tmax) and mean transit times (MTT) were compared with SPECT data. -RESULTS: 99m Tc-HMPAO SPECT demonstrated an impairment of CVR in six patients. A preserved CVR was present in seven patients. All patients with impaired CVR proven by SPECT had a delayed MTT (mean +2.98 s) and a delayed Tmax (mean + 5.9 s), (both p <0.005 compared with the non occluded side). 66% of patients with impaired CVR in SPECT showed a complete correlation of Tmax measurements in PCT with a high positive predictive value (PPV: 88.8%). -CONCLUSION: The prospective study demonstrated a highly significant correlation of perfusion parameters as detected by 99m Tc-HMPAO SPECT and the Tmax as detected by PCT in patients with ICA occlusion. Therefore this easy-to-perform technique seems to be an adequate method for the evaluation of cerebral perfusion in patients with ICA occlusion.

AB - BACKGROUND AND PURPOSE: Patients with internal carotid artery (ICA) occlusion can demonstrate impaired cerebral vascular reserve (CVR). The detection of CVR using single photon emission CT (SPECT) is nowadays widely accepted as a predictor in the diagnostic pathway in patients considered for cerebral revascularization. Recently perfusion CT (PCT) gained widely acceptance in stroke imaging. The present study was aimed at comparing the results of perfusion CT (PCT) and 99m Tc-HMPAO SPECT with acetazolamide challenge in patients with ICA occlusion.METHODS: 13 patients were included in the prospective evaluation. Both PCT and 99m Tc-HMPAO SPECT were performed before and after the administration of acetazolamide. In detail, regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), adapted time to peak (Tmax) and mean transit times (MTT) were compared with SPECT data. -RESULTS: 99m Tc-HMPAO SPECT demonstrated an impairment of CVR in six patients. A preserved CVR was present in seven patients. All patients with impaired CVR proven by SPECT had a delayed MTT (mean +2.98 s) and a delayed Tmax (mean + 5.9 s), (both p <0.005 compared with the non occluded side). 66% of patients with impaired CVR in SPECT showed a complete correlation of Tmax measurements in PCT with a high positive predictive value (PPV: 88.8%). -CONCLUSION: The prospective study demonstrated a highly significant correlation of perfusion parameters as detected by 99m Tc-HMPAO SPECT and the Tmax as detected by PCT in patients with ICA occlusion. Therefore this easy-to-perform technique seems to be an adequate method for the evaluation of cerebral perfusion in patients with ICA occlusion.

KW - Adolescent

KW - Adult

KW - Aged

KW - Arterial Occlusive Diseases

KW - Blood Volume

KW - Brain Mapping

KW - Carotid Artery, Internal

KW - Cerebrovascular Circulation

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Perfusion

KW - Regional Blood Flow

KW - Technetium Tc 99m Exametazime

KW - Time Factors

KW - Tomography, Emission-Computed, Single-Photon

KW - Tomography, X-Ray Computed

KW - Young Adult

M3 - SCORING: Journal article

C2 - 22027641

VL - 16

SP - 484

EP - 490

JO - EUR J MED RES

JF - EUR J MED RES

SN - 0949-2321

IS - 11

ER -