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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.

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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. / Haiman, Christopher A; Chen, Gary K; Vachon, Celine M; Canzian, Federico; Dunning, Alison; Millikan, Robert C; Wang, Xianshu; Ademuyiwa, Foluso; Ahmed, Shahana; Ambrosone, Christine B; Baglietto, Laura; Balleine, Rosemary; Bandera, Elisa V; Beckmann, Matthias W; Berg, Christine D; Bernstein, Leslie; Blomqvist, Carl; Blot, William J; Brauch, Hiltrud; Buring, Julie E; Carey, Lisa A; Carpenter, Jane E; Chang-Claude, Jenny; Chanock, Stephen J; Chasman, Daniel I; Clarke, Christine L; Cox, Angela; Cross, Simon S; Deming, Sandra L; Diasio, Robert B; Dimopoulos, Athanasios M; Driver, W Ryan; Dünnebier, Thomas; Durcan, Lorraine; Eccles, Diana; Edlund, Christopher K; Ekici, Arif B; Fasching, Peter A; Feigelson, Heather S; Flesch-Janys, Dieter; Fostira, Florentia; Försti, Asta; Fountzilas, George; Gerty, Susan M; Interaction, Gene Environment; Consortium, Breast Cancer In Germany; Giles, Graham G; Godwin, Andrew K; Goodfellow, Paul; Graham, Nikki; Greco, Dario; Hamann, Ute; Hankinson, Susan E; Hartmann, Arndt; Hein, Rebecca; Heinz, Judith; Holbrook, Andrea; Hoover, Robert N; Hu, Jennifer J; Hunter, David J; Ingles, Sue A; Irwanto, Astrid; Ivanovich, Jennifer; John, Esther M; Johnson, Nicola; Jukkola-Vuorinen, Arja; Kaaks, Rudolf; Ko, Yon-Dschun; Kolonel, Laurence N; Konstantopoulou, Irene; Kosma, Veli-Matti; Kulkarni, Swati; Lambrechts, Diether; Lee, Adam M; Marchand, Loïc Le; Lesnick, Timothy; Liu, Jianjun; Lindstrom, Sara; Mannermaa, Arto; Margolin, Sara; Martin, Nicholas G; Miron, Penelope; Montgomery, Grant W; Nevanlinna, Heli; Nickels, Stephan; Nyante, Sarah; Olswold, Curtis; Palmer, Julie; Pathak, Harsh; Pectasides, Dimitrios; Perou, Charles M; Peto, Julian; Pharoah, Paul D P; Pooler, Loreall C; Press, Michael F; Pylkäs, Katri; Rebbeck, Timothy R; Rodriguez-Gil, Jorge L; Rosenberg, Lynn; Ross, Eric; Rüdiger, Thomas; Silva, Isabel Dos Santos; Sawyer, Elinor; Schmidt, Marjanka K; Schulz-Wendtland, Rüdiger; Schumacher, Fredrick; Severi, Gianluca; Sheng, Xin; Signorello, Lisa B; Sinn, Hans-Peter; Stevens, Kristen N; Southey, Melissa C; Tapper, William J; Tomlinson, Ian; Hogervorst, Frans B L; Wauters, Els; Weaver, JoEllen; Wildiers, Hans; Winqvist, Robert; David, Van Den Berg; Wan, Peggy; Xia, Lucy Y; Yannoukakos, Drakoulis; Zheng, Wei; Ziegler, Regina G; Siddiq, Afshan; Slager, Susan L; Stram, Daniel O; Easton, Douglas; Kraft, Peter; Henderson, Brian E; Couch, Fergus J.

In: NAT GENET, Vol. 43, No. 12, 12, 2011, p. 1210-1214.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Haiman, CA, Chen, GK, Vachon, CM, Canzian, F, Dunning, A, Millikan, RC, Wang, X, Ademuyiwa, F, Ahmed, S, Ambrosone, CB, Baglietto, L, Balleine, R, Bandera, EV, Beckmann, MW, Berg, CD, Bernstein, L, Blomqvist, C, Blot, WJ, Brauch, H, Buring, JE, Carey, LA, Carpenter, JE, Chang-Claude, J, Chanock, SJ, Chasman, DI, Clarke, CL, Cox, A, Cross, SS, Deming, SL, Diasio, RB, Dimopoulos, AM, Driver, WR, Dünnebier, T, Durcan, L, Eccles, D, Edlund, CK, Ekici, AB, Fasching, PA, Feigelson, HS, Flesch-Janys, D, Fostira, F, Försti, A, Fountzilas, G, Gerty, SM, Interaction, GE, Consortium, BCIG, Giles, GG, Godwin, AK, Goodfellow, P, Graham, N, Greco, D, Hamann, U, Hankinson, SE, Hartmann, A, Hein, R, Heinz, J, Holbrook, A, Hoover, RN, Hu, JJ, Hunter, DJ, Ingles, SA, Irwanto, A, Ivanovich, J, John, EM, Johnson, N, Jukkola-Vuorinen, A, Kaaks, R, Ko, Y-D, Kolonel, LN, Konstantopoulou, I, Kosma, V-M, Kulkarni, S, Lambrechts, D, Lee, AM, Marchand, LL, Lesnick, T, Liu, J, Lindstrom, S, Mannermaa, A, Margolin, S, Martin, NG, Miron, P, Montgomery, GW, Nevanlinna, H, Nickels, S, Nyante, S, Olswold, C, Palmer, J, Pathak, H, Pectasides, D, Perou, CM, Peto, J, Pharoah, PDP, Pooler, LC, Press, MF, Pylkäs, K, Rebbeck, TR, Rodriguez-Gil, JL, Rosenberg, L, Ross, E, Rüdiger, T, Silva, IDS, Sawyer, E, Schmidt, MK, Schulz-Wendtland, R, Schumacher, F, Severi, G, Sheng, X, Signorello, LB, Sinn, H-P, Stevens, KN, Southey, MC, Tapper, WJ, Tomlinson, I, Hogervorst, FBL, Wauters, E, Weaver, J, Wildiers, H, Winqvist, R, David, VDB, Wan, P, Xia, LY, Yannoukakos, D, Zheng, W, Ziegler, RG, Siddiq, A, Slager, SL, Stram, DO, Easton, D, Kraft, P, Henderson, BE & Couch, FJ 2011, 'A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.', NAT GENET, vol. 43, no. 12, 12, pp. 1210-1214. <http://www.ncbi.nlm.nih.gov/pubmed/22037553?dopt=Citation>

APA

Haiman, C. A., Chen, G. K., Vachon, C. M., Canzian, F., Dunning, A., Millikan, R. C., Wang, X., Ademuyiwa, F., Ahmed, S., Ambrosone, C. B., Baglietto, L., Balleine, R., Bandera, E. V., Beckmann, M. W., Berg, C. D., Bernstein, L., Blomqvist, C., Blot, W. J., Brauch, H., ... Couch, F. J. (2011). A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. NAT GENET, 43(12), 1210-1214. [12]. http://www.ncbi.nlm.nih.gov/pubmed/22037553?dopt=Citation

Vancouver

Haiman CA, Chen GK, Vachon CM, Canzian F, Dunning A, Millikan RC et al. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. NAT GENET. 2011;43(12):1210-1214. 12.

Bibtex

@article{b5de11413f7649679a18fc1799a361b6,
title = "A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.",
abstract = "Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10(-9)), particularly in younger women (",
keywords = "Humans, Aged, Female, Middle Aged, Genotype, Genetic Predisposition to Disease, European Continental Ancestry Group, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Case-Control Studies, Membrane Proteins/*genetics, African Americans, Breast Neoplasms/ethnology/*genetics/metabolism, *Genetic Loci, Neoplasm Proteins/*genetics, Receptors, Estrogen/genetics/*metabolism, Telomerase/*genetics, Humans, Aged, Female, Middle Aged, Genotype, Genetic Predisposition to Disease, European Continental Ancestry Group, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Case-Control Studies, Membrane Proteins/*genetics, African Americans, Breast Neoplasms/ethnology/*genetics/metabolism, *Genetic Loci, Neoplasm Proteins/*genetics, Receptors, Estrogen/genetics/*metabolism, Telomerase/*genetics",
author = "Haiman, {Christopher A} and Chen, {Gary K} and Vachon, {Celine M} and Federico Canzian and Alison Dunning and Millikan, {Robert C} and Xianshu Wang and Foluso Ademuyiwa and Shahana Ahmed and Ambrosone, {Christine B} and Laura Baglietto and Rosemary Balleine and Bandera, {Elisa V} and Beckmann, {Matthias W} and Berg, {Christine D} and Leslie Bernstein and Carl Blomqvist and Blot, {William J} and Hiltrud Brauch and Buring, {Julie E} and Carey, {Lisa A} and Carpenter, {Jane E} and Jenny Chang-Claude and Chanock, {Stephen J} and Chasman, {Daniel I} and Clarke, {Christine L} and Angela Cox and Cross, {Simon S} and Deming, {Sandra L} and Diasio, {Robert B} and Dimopoulos, {Athanasios M} and Driver, {W Ryan} and Thomas D{\"u}nnebier and Lorraine Durcan and Diana Eccles and Edlund, {Christopher K} and Ekici, {Arif B} and Fasching, {Peter A} and Feigelson, {Heather S} and Dieter Flesch-Janys and Florentia Fostira and Asta F{\"o}rsti and George Fountzilas and Gerty, {Susan M} and Interaction, {Gene Environment} and Consortium, {Breast Cancer In Germany} and Giles, {Graham G} and Godwin, {Andrew K} and Paul Goodfellow and Nikki Graham and Dario Greco and Ute Hamann and Hankinson, {Susan E} and Arndt Hartmann and Rebecca Hein and Judith Heinz and Andrea Holbrook and Hoover, {Robert N} and Hu, {Jennifer J} and Hunter, {David J} and Ingles, {Sue A} and Astrid Irwanto and Jennifer Ivanovich and John, {Esther M} and Nicola Johnson and Arja Jukkola-Vuorinen and Rudolf Kaaks and Yon-Dschun Ko and Kolonel, {Laurence N} and Irene Konstantopoulou and Veli-Matti Kosma and Swati Kulkarni and Diether Lambrechts and Lee, {Adam M} and Marchand, {Lo{\"i}c Le} and Timothy Lesnick and Jianjun Liu and Sara Lindstrom and Arto Mannermaa and Sara Margolin and Martin, {Nicholas G} and Penelope Miron and Montgomery, {Grant W} and Heli Nevanlinna and Stephan Nickels and Sarah Nyante and Curtis Olswold and Julie Palmer and Harsh Pathak and Dimitrios Pectasides and Perou, {Charles M} and Julian Peto and Pharoah, {Paul D P} and Pooler, {Loreall C} and Press, {Michael F} and Katri Pylk{\"a}s and Rebbeck, {Timothy R} and Rodriguez-Gil, {Jorge L} and Lynn Rosenberg and Eric Ross and Thomas R{\"u}diger and Silva, {Isabel Dos Santos} and Elinor Sawyer and Schmidt, {Marjanka K} and R{\"u}diger Schulz-Wendtland and Fredrick Schumacher and Gianluca Severi and Xin Sheng and Signorello, {Lisa B} and Hans-Peter Sinn and Stevens, {Kristen N} and Southey, {Melissa C} and Tapper, {William J} and Ian Tomlinson and Hogervorst, {Frans B L} and Els Wauters and JoEllen Weaver and Hans Wildiers and Robert Winqvist and David, {Van Den Berg} and Peggy Wan and Xia, {Lucy Y} and Drakoulis Yannoukakos and Wei Zheng and Ziegler, {Regina G} and Afshan Siddiq and Slager, {Susan L} and Stram, {Daniel O} and Douglas Easton and Peter Kraft and Henderson, {Brian E} and Couch, {Fergus J}",
year = "2011",
language = "English",
volume = "43",
pages = "1210--1214",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "12",

}

RIS

TY - JOUR

T1 - A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.

AU - Haiman, Christopher A

AU - Chen, Gary K

AU - Vachon, Celine M

AU - Canzian, Federico

AU - Dunning, Alison

AU - Millikan, Robert C

AU - Wang, Xianshu

AU - Ademuyiwa, Foluso

AU - Ahmed, Shahana

AU - Ambrosone, Christine B

AU - Baglietto, Laura

AU - Balleine, Rosemary

AU - Bandera, Elisa V

AU - Beckmann, Matthias W

AU - Berg, Christine D

AU - Bernstein, Leslie

AU - Blomqvist, Carl

AU - Blot, William J

AU - Brauch, Hiltrud

AU - Buring, Julie E

AU - Carey, Lisa A

AU - Carpenter, Jane E

AU - Chang-Claude, Jenny

AU - Chanock, Stephen J

AU - Chasman, Daniel I

AU - Clarke, Christine L

AU - Cox, Angela

AU - Cross, Simon S

AU - Deming, Sandra L

AU - Diasio, Robert B

AU - Dimopoulos, Athanasios M

AU - Driver, W Ryan

AU - Dünnebier, Thomas

AU - Durcan, Lorraine

AU - Eccles, Diana

AU - Edlund, Christopher K

AU - Ekici, Arif B

AU - Fasching, Peter A

AU - Feigelson, Heather S

AU - Flesch-Janys, Dieter

AU - Fostira, Florentia

AU - Försti, Asta

AU - Fountzilas, George

AU - Gerty, Susan M

AU - Interaction, Gene Environment

AU - Consortium, Breast Cancer In Germany

AU - Giles, Graham G

AU - Godwin, Andrew K

AU - Goodfellow, Paul

AU - Graham, Nikki

AU - Greco, Dario

AU - Hamann, Ute

AU - Hankinson, Susan E

AU - Hartmann, Arndt

AU - Hein, Rebecca

AU - Heinz, Judith

AU - Holbrook, Andrea

AU - Hoover, Robert N

AU - Hu, Jennifer J

AU - Hunter, David J

AU - Ingles, Sue A

AU - Irwanto, Astrid

AU - Ivanovich, Jennifer

AU - John, Esther M

AU - Johnson, Nicola

AU - Jukkola-Vuorinen, Arja

AU - Kaaks, Rudolf

AU - Ko, Yon-Dschun

AU - Kolonel, Laurence N

AU - Konstantopoulou, Irene

AU - Kosma, Veli-Matti

AU - Kulkarni, Swati

AU - Lambrechts, Diether

AU - Lee, Adam M

AU - Marchand, Loïc Le

AU - Lesnick, Timothy

AU - Liu, Jianjun

AU - Lindstrom, Sara

AU - Mannermaa, Arto

AU - Margolin, Sara

AU - Martin, Nicholas G

AU - Miron, Penelope

AU - Montgomery, Grant W

AU - Nevanlinna, Heli

AU - Nickels, Stephan

AU - Nyante, Sarah

AU - Olswold, Curtis

AU - Palmer, Julie

AU - Pathak, Harsh

AU - Pectasides, Dimitrios

AU - Perou, Charles M

AU - Peto, Julian

AU - Pharoah, Paul D P

AU - Pooler, Loreall C

AU - Press, Michael F

AU - Pylkäs, Katri

AU - Rebbeck, Timothy R

AU - Rodriguez-Gil, Jorge L

AU - Rosenberg, Lynn

AU - Ross, Eric

AU - Rüdiger, Thomas

AU - Silva, Isabel Dos Santos

AU - Sawyer, Elinor

AU - Schmidt, Marjanka K

AU - Schulz-Wendtland, Rüdiger

AU - Schumacher, Fredrick

AU - Severi, Gianluca

AU - Sheng, Xin

AU - Signorello, Lisa B

AU - Sinn, Hans-Peter

AU - Stevens, Kristen N

AU - Southey, Melissa C

AU - Tapper, William J

AU - Tomlinson, Ian

AU - Hogervorst, Frans B L

AU - Wauters, Els

AU - Weaver, JoEllen

AU - Wildiers, Hans

AU - Winqvist, Robert

AU - David, Van Den Berg

AU - Wan, Peggy

AU - Xia, Lucy Y

AU - Yannoukakos, Drakoulis

AU - Zheng, Wei

AU - Ziegler, Regina G

AU - Siddiq, Afshan

AU - Slager, Susan L

AU - Stram, Daniel O

AU - Easton, Douglas

AU - Kraft, Peter

AU - Henderson, Brian E

AU - Couch, Fergus J

PY - 2011

Y1 - 2011

N2 - Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10(-9)), particularly in younger women (

AB - Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10(-9)), particularly in younger women (

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Genotype

KW - Genetic Predisposition to Disease

KW - European Continental Ancestry Group

KW - Genome-Wide Association Study

KW - Polymorphism, Single Nucleotide

KW - Case-Control Studies

KW - Membrane Proteins/genetics

KW - African Americans

KW - Breast Neoplasms/ethnology/genetics/metabolism

KW - Genetic Loci

KW - Neoplasm Proteins/genetics

KW - Receptors, Estrogen/genetics/metabolism

KW - Telomerase/genetics

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Genotype

KW - Genetic Predisposition to Disease

KW - European Continental Ancestry Group

KW - Genome-Wide Association Study

KW - Polymorphism, Single Nucleotide

KW - Case-Control Studies

KW - Membrane Proteins/genetics

KW - African Americans

KW - Breast Neoplasms/ethnology/genetics/metabolism

KW - Genetic Loci

KW - Neoplasm Proteins/genetics

KW - Receptors, Estrogen/genetics/metabolism

KW - Telomerase/genetics

M3 - SCORING: Journal article

VL - 43

SP - 1210

EP - 1214

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 12

M1 - 12

ER -