Research ExplorerScientific StaffGeorg Rosenberger Publications

Dr. ID: 37508

Georg Rosenberger

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Affiliations
ORCID: 0000-0003-3625-3109
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Publications

  1. 1999

  2. Benzamide riboside induces apoptosis independent of Cdc25A expression in human ovarian carcinoma N.1 cells

    Grusch, M., Rosenberger, G., Fuhrmann, G., Braun, K., Titscher, B., Szekeres, T., Fritzer-Skekeres, M., Oberhuber, G., Krohn, K., Hengstschlaeger, M., Krupitza, G. & Jayaram, H. N., 01.08.1999, In: CELL DEATH DIFFER. 6, 8, p. 736-44 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. The MYC dualism in growth and death

    Fuhrmann, G., Rosenberger, G., Grusch, M., Klein, N., Hofmann, J. & Krupitza, G., 01.11.1999, In: MUTAT RES-FUND MOL M. 437, 3, p. 205-17 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. 2000

  5. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease

    Fichtlscherer, S., Rosenberger, G., Walter, D. H., Breuer, S., Dimmeler, S. & Zeiher, A. M., 29.08.2000, In: CIRCULATION. 102, 9, p. 1000-6 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells

    Rosenberger, G., Fuhrmann, G., Grusch, M., Fassl, S., Elford, H. L., Smid, K., Peters, G. J., Szekeres, T. & Krupitza, G., 17.11.2000, In: LIFE SCI. 67, 26, p. 3131-42 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. 2001

  8. Activation of caspases and induction of apoptosis by novel ribonucleotide reductase inhibitors amidox and didox

    Grusch, M., Fritzer-Szekeres, M., Fuhrmann, G., Rosenberger, G., Luxbacher, C., Elford, H. L., Smid, K., Peters, G. J., Szekeres, T. & Krupitza, G., 01.05.2001, In: Experimental hematology. 29, 5, p. 623-32 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Cdc25A phosphatase suppresses apoptosis induced by serum deprivation

    Fuhrmann, G., Leisser, C., Rosenberger, G., Grusch, M., Huettenbrenner, S., Halama, T., Mosberger, I., Sasgary, S., Cerni, C. & Krupitza, G., 27.07.2001, In: ONCOGENE. 20, 33, p. 4542-53 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. 2003

  11. Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling

    Rosenberger, G., Jantke, I., Gal, A. & Kutsche, K., 15.01.2003, In: HUM MOL GENET. 12, 2, p. 155-67 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFalpha, FasL, TRAIL, or Myc

    Fassl, S., Leisser, C., Huettenbrenner, S., Maier, S., Rosenberger, G., Strasser, S., Grusch, M., Fuhrmann, G., Leuhuber, K., Polgar, D., Stani, J., Tichy, B., Nowotny, C. & Krupitza, G., 13.11.2003, In: ONCOGENE. 22, 51, p. 8343-55 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. 2004

  14. Subcellular localisation of Cdc25A determines cell fate

    Leisser, C., Rosenberger, G., Maier, S., Fuhrmann, G., Grusch, M., Strasser, S., Huettenbrenner, S., Fassl, S., Polgar, D., Krieger, S., Cerni, C., Hofer-Warbinek, R., deMartin, R. & Krupitza, G., 01.01.2004, In: CELL DEATH DIFFER. 11, 1, p. 80-9 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. 2005

  16. Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin

    Hartwig, C., Veske, A., Krejcova, S., Rosenberger, G. & Finckh, U., 01.01.2005, In: BMC NEUROSCI. 6, p. 53

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. 2006

  18. AlphaPIX and betaPIX and their role in focal adhesion formation

    Rosenberger, G. & Kutsche, K., 2006, In: EUR J CELL BIOL. 85, 3-4, p. 265-274 10 p., 3-4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome.

    Rau, I., Morleo, M., Rosenberger, G., Iaconis, D., Orth, U., Meinecke, P., Lerer, I., Ballabio, A., Gal, A., Franco, B. & Kutsche, K., 2006, In: AM J HUM GENET. 79, 5, p. 878-889 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation.

    Gringel, A., Walz, D., Rosenberger, G., Minden, A., Kutsche, K., Kopp, P. & Linder, S., 2006, In: J CELL PHYSIOL. 209, 2, p. 568-579 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. 2008

  22. Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.

    Kim, H-G., Kurth, I., Lan, F., Meliciani, I., Wenzel, W., Eom, S. H., Kang, G. B., Rosenberger, G., Tekin, M., Ozata, M., Bick, D. P., Sherins, R. J., Walker, S. L., Shi, Y., Gusella, J. F. & Layman, L. C., 2008, In: AM J HUM GENET. 83, 4, p. 511-519 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. 2009

  24. Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation.

    Gremer, L., Alessandro, D. L., Merbitz-Zahradnik, T., Dallapiccola, B., Morlot, S., Tartaglia, M., Kutsche, K., Ahmadian, M. R. & Rosenberger, G., 2009, In: HUM MOL GENET.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. Oncogenic HRAS mutations cause prolonged PI3K signaling in response to epidermal growth factor in fibroblasts of patients with Costello syndrome.

    Rosenberger, G., Meien, S. & Kutsche, K., 2009, In: HUM MUTAT. 30, 3, p. 352-362 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. 2010

  27. Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.

    Endele, S., Rosenberger, G., Geider, K., Popp, B., Tamer, C., Stefanova, I., Milh, M., Kortüm, F., Fritsch, A., Pientka, F. K., Hellenbroich, Y., Kalscheuer, V. M., Kohlhase, J., Moog, U., Rappold, G., Rauch, A., Ropers, H-H., von Spiczak, S., Tönnies, H., Villeneuve, N., Villard, L., Zabel, B., Zenker, M., Laube, B., Reis, A., Wieczorek, D., Lionel, V. M. & Kutsche, K., 2010, In: NAT GENET. 42, 11, p. 1021-1026 11.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.

    Kim, H-G., Ahn, J-W., Kurth, I., Ullmann, R., Kim, H-T., Kulharya, A., Ha, K-S., Itokawa, Y., Meliciani, I., Wenzel, W., Lee, D., Rosenberger, G., Ozata, M., Bick, D. P., Sherins, R. J., Nagase, T., Tekin, M., Kim, S-H., Kim, C-H., Ropers, H-H., Gusella, J. F., Kalscheuer, V., Choi, C. Y. & Layman, L. C., 2010, In: AM J HUM GENET. 87, 4, p. 465-479 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. 2011

  30. Hallermann-Streiff Syndrome: No Evidence for a Link to Laminopathies.

    Kortüm, F., Chyrek, M., Fuchs, S., Albrecht, B., Gillessen-Kaesbach, G., Mütze, U., Seemanova, E., Tinschert, S., Wieczorek, D., Rosenberger, G. & Kutsche, K., 2011, In: MOL SYNDROMOL. 2, 1, p. 27-34 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity.

    Hua, K-T., Tan, C-T., Johansson, G., Lee, J-M., Yang, P-W., Lu, H-Y., Chen, C-K., Su, J-L., Chen, P. B., Wu, Y-L., Chi, C-C., Kao, H-J., Shih, H-J., Chen, M-W., Chien, M-H., Chen, P-S., Lee, W-J., Cheng, T-Y., Rosenberger, G., Chai, C-Y., Yang, C-J., Huang, M-S., Lai, T-C., Chou, T-Y., Hsiao, M. & Kuo, M-L., 2011, In: CANCER CELL. 19, 2, p. 218-231 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. 2012

  33. A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development.

    Gripp, K. W., Bifeld, E., Stabley, D. L., Hopkins, E., Meien, S., Vinette, K., Sol-Church, K. & Rosenberger, G., 2012, In: AM J MED GENET A. 158A, 9, p. 2106-2118 9.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.

    Ramakers, G. J. A., Wolfer, D., Rosenberger, G., Kuchenbecker, K., Kreienkamp, H-J., Prange-Kiel, J., Rune, G. M., Richter, K., Langnaese, K., Masneuf, S., Bösl, M. R., Fischer, K-D., Krugers, H. J., Lipp, H-P., van Galen, E. & Kutsche, K., 2012, In: HUM MOL GENET. 21, 2, p. 268-286 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. 2013

  36. Functional analysis of a duplication (p.E63_D69dup) in the switch II region of HRAS: new aspects of the molecular pathogenesis underlying Costello syndrome

    Lorenz, S., Lissewski, C., Simsek-Kiper, P. O., Alanay, Y., Boduroglu, K., Zenker, M. & Rosenberger, G., 15.04.2013, In: HUM MOL GENET. 22, 8, p. 1643-53 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor αPIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neurons

    Meseke, M., Rosenberger, G. & Förster, E., 01.05.2013, In: EUR J NEUROSCI. 37, 9, p. 1404-12 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  38. A 1-bp duplication in TGFB2 in three family members with a syndromic form of thoracic aortic aneurysm

    Leutermann, R., Sheikhzadeh, S., Brockstädt, L., Rybczynski, M., van Rahden, V., Kutsche, K., Kodolitsch, Y. & Rosenberger, G., 06.11.2013, In: EUR J HUM GENET. 22, p. 944-948

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. Dysfunction of SHANK2 and CHRNA7 in a patient with intellectual disability and language impairment supports genetic epistasis of the two loci

    Chilian, B., Abdollahpour, H., Bierhals, T., Haltrich, I., Fekete, G., Nagel, I., Rosenberger, G. & Kutsche, K., 01.12.2013, In: CLIN GENET. 84, 6, p. 560-5 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. 2014

  41. Exom-Sequenzierung zur Identifizierung von Krankheitsgenen für seltene Syndrome: Erfahrungen aus Hamburg

    Kortüm, F., Abdollahpour, H., Alawi, M., Korenke, G. C., Seemanova, E., Tinschert, S., Zenker, M., Rosenberger, G. & Kutsche, K., 12.06.2014, In: MED GENET-BERLIN. 26, p. 246-254

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR

    Brand, K., Kentsch, H., Glashoff, C. & Rosenberger, G., 01.11.2014, In: HUM MUTAT. 35, 11, p. 1372-81 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. 2015

  44. An AP4B1 frameshift mutation in siblings with intellectual disability and spastic tetraplegia further delineates the AP-4 deficiency syndrome

    Abdollahpour, H., Alawi, M., Kortüm, F., Beckstette, M., Seemanova, E., Komárek, V., Rosenberger, G. & Kutsche, K., 2015, In: EUR J HUM GENET. 23, 2, p. 256-259

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor

    Kortüm, F., Harms, F. L., Hennighausen, N. & Rosenberger, G., 2015, In: PLOS ONE. 10, 7, p. e0132737

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences

    Gripp, K. W., Sol-Church, K., Smpokou, P., Graham, G. E., Stevenson, D. A., Hanson, H., Viskochil, D. H., Baker, L. C., Russo, B., Gardner, N., Stabley, D. L., Kolbe, V. & Rosenberger, G., 09.2015, In: AM J MED GENET A. 167A, 9, p. 2085-97 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. 2016

  48. The role of the multidisciplinary health care team in the management of patients with Marfan syndrome

    von Kodolitsch, Y., Rybczynski, M., Vogler, M., Mir, T. S., Schüler, H., Kutsche, K., Rosenberger, G., Detter, C., Bernhardt, A. M., Larena-Avellaneda, A., Kölbel, T., Debus, E. S., Schroeder, M., Linke, S. J., Fuisting, B., Napp, B., Kammal, A. L., Püschel, K., Bannas, P., Hoffmann, B. A., Gessler, N., Vahle-Hinz, E., Kahl-Nieke, B., Thomalla, G., Weiler-Normann, C., Ohm, G., Neumann, S., Benninghoven, D., Blankenberg, S. & Pyeritz, R. E., 2016, In: J MULTIDISCIP HEALTH. 9, p. 587-614 28 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. 2017

  50. Attenuated phenotype of Costello syndrome and early death in a patient with an HRAS Mutation (c.179G>T; p.Gly60Val) affecting signalling dynamics

    Gripp, K. W., Kolbe, V., Brandenstein, L. I. & Rosenberger, G., 31.01.2017, In: CLIN GENET. 92, 3, p. 332-337

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. 2018

  52. RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1

    Meyer Zum Büschenfelde, U., Brandenstein, L. I., von Elsner, L., Flato, K., Holling, T., Zenker, M., Rosenberger, G. & Kutsche, K., 05.2018, In: PLOS GENET. 14, 5, p. e1007370

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  53. A novel missense variant in the SDR domain of the WWOX gene leads to complete loss of WWOX protein with early-onset epileptic encephalopathy and severe developmental delay

    Johannsen, J., Kortüm, F., Rosenberger, G., Bokelmann, K., Schirmer, M. A., Denecke, J. & Santer, R., 08.2018, In: NEUROGENETICS. 19, 3, p. 151-156 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  54. 2019

  55. 16p13.11 microdeletion uncovers loss-of-function of a MYH11 missense variant in a patient with megacystis-microcolon-intestinal-hypoperistalsis syndrome

    Kloth, K., Renner, S., Burmester, G., Steinemann, D., Pabst, B., Lorenz, B., Simon, R., Kolbe, V., Hempel, M. & Rosenberger, G., 07.2019, In: CLIN GENET. 96, 1, p. 85-90 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  56. Next-generation sequencing of 32 genes associated with hereditary aortopathies and related disorders of connective tissue in a cohort of 199 patients

    Renner, S., Schüler, H., Alawi, M., Kolbe, V., Rybczynski, M., Woitschach, R., Sheikhzadeh, S., Stark, V. C., Olfe, J., Roser, E., Seggewies, F. S., Mahlmann, A., Hempel, M., Hartmann, M. J., Hillebrand, M., Wieczorek, D., Volk, A. E., Kloth, K., Koch-Hogrebe, M., Abou Jamra, R., Mitter, D., Altmüller, J., Wey-Fabrizius, A., Petersen, C., Rau, I., Borck, G., Kubisch, C., Mir, T. S., von Kodolitsch, Y., Kutsche, K. & Rosenberger, G., 08.2019, In: GENET MED. 21, 8, p. 1832-1841 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  57. 2020

  58. Exome sequencing in 38 patients with intracranial aneurysms and subarachnoid hemorrhage

    Sauvigny, T., Alawi, M., Krause, L., Renner, S., Spohn, M., Busch, A., Kolbe, V., Altmüller, J., Löscher, B-S., Franke, A., Brockmann, C., Lieb, W., Westphal, M., Schmidt, N. O., Regelsberger, J. & Rosenberger, G., 09.2020, In: J NEUROL. 267, 9, p. 2533-2545 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  59. The novel duplication HRAS c.186_206dup p.(Glu62_Arg68dup): clinical and functional aspects

    Gripp, K. W., Baker, L., Robbins, K. M., Stabley, D. L., Bellus, G. A., Kolbe, V., Nauth, T. & Rosenberger, G., 11.2020, In: EUR J HUM GENET. 28, 11, p. 1548-1554 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  60. 2022

  61. Expanding the clinical spectrum of COL2A1 related disorders by a MASS like phenotype

    Demal, T. J., Scholz, T., Schüler, H., Olfe, J., Fröhlich, A., Speth, F., von Kodolitsch, Y., Mir, T. S., Reichenspurner, H., Kubisch, C., Hempel, M. & Rosenberger, G., 16.03.2022, In: SCI REP-UK. 12, 1, p. 4489

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  62. The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load

    Thievessen, I., Suhr, F., Vergarajauregui, S., Böttcher, R. T., Brixius, K., Rosenberger, G., Dewald, O., Fleischmann, B. K., Ghanem, A., Krüger, M., Engel, F. B., Fabry, B., Bloch, W. & Fässler, R., 25.07.2022, In: CURR BIOL. 32, 14, p. 3033-3047.e9

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  63. A novel HRAS c.466C>T p.(Phe156Leu) variant in two patients with attenuated features of Costello syndrome

    Lindsey-Temple, S., Edwards, M., Rickassel, V., Nauth, T. & Rosenberger, G., 09.2022, In: EUR J HUM GENET. 30, 9, p. 1088-1093 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  64. 2023

  65. Cutaneous manifestations in Costello syndrome: HRAS p.Gly12Ser affects RIN1-mediated integrin trafficking in immortalized epidermal keratinocytes

    Nauth, T., Bazgir, F., Voß, H., Brandenstein, L. I., Mosaddeghzadeh, N., Rickassel, V., Deden, S., Gorzelanny, C., Schlüter, H., Ahmadian, M. R. & Rosenberger, G., 06.01.2023, In: HUM MOL GENET. 32, 2, p. 304-318 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  66. Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs

    Klämbt, V., Buerger, F., Wang, C., Naert, T., Richter, K., Nauth, T., Weiss, A-C., Sieckmann, T., Lai, E., Connaughton, D., Seltzsam, S., Mann, N., Majmundar, A., Wu, C-H., Onuchic-Whitford, A., Shril, S., Schneider, S., Schierbaum, L., Dai, R., Bekheirnia, M. R., Joosten, M., Shlomovitz, O., Vivante, A., Banne, E., Mane, S., Lifton, R. P., Kirschner, K., Kispert, A., Rosenberger, G., Fischer, K-D., Lienkamp, S., Zegers, M. & Hildebrandt, F., 01.02.2023, In: J AM SOC NEPHROL. 34, 2, p. 273-290 18 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review