Dr.med. ID: 6218005
Christian Schlein
Publications
Clinical and pathological characteristics of familial melanoma with germline TERT promoter variants
Zaremba, A., Meier, F., Schlein, C., Jansen, P., Lodde, G., Song, M., Kretz, J., Möller, I., Stadtler, N., Livingstone, E., Zimmer, L., Hadaschik, E., Sucker, A., Schadendorf, D. & Griewank, K., 11.2022, In: PIGM CELL MELANOMA R. 35, 6, p. 573-586 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
Worthmann, A., John, C., Rühlemann, M. C., Baguhl, M., Heinsen, F-A., Schaltenberg, N., Heine, M., Schlein, C., Evangelakos, I., Mineo, C., Fischer, M., Dandri, M., Kremoser, C., Scheja, L., Franke, A., Shaul, P. W. & Heeren, J., 07.2017, In: NAT MED. 23, 7, p. 839-849 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression
Worthmann, A., Schlein, C., Berbée, J. F. P., Rensen, P. C. N., Heeren, J. & Bartelt, A., 23.02.2019, In: NUTRIENTS. 11, 2Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
Worthmann, A., Ridder, J., Piel, S. Y. L., Evangelakos, I., Musfeldt, M., Voß, H., O'Farrell, M., Fischer, A. W., Adak, S., Sundd, M., Siffeti, H., Haumann, F., Kloth, K., Bierhals, T., Heine, M., Pertzborn, P., Pauly, M., Scholz, J-J., Kundu, S., Fuh, M. M., Neu, A., Tödter, K., Hempel, M., Knippschild, U., Semenkovich, C. F., Schlüter, H., Heeren, J., Scheja, L., Kubisch, C. & Schlein, C., 02.01.2024, In: NAT COMMUN. 15, 1, p. 45Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity
Wagner, T., Bartelt, A., Schlein, C. & Heeren, J., 2015, In: PLOS ONE. 10, 12, e0145102.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings
Schmidt, A., Danyel, M., Grundmann, K., Brunet, T., Klinkhammer, H., Hsieh, T-C., Engels, H., Peters, S., Knaus, A., Moosa, S., Averdunk, L., Boschann, F., Sczakiel, H. L., Schwartzmann, S., Mensah, M. A., Pantel, J. T., Holtgrewe, M., Bösch, A., Weiß, C., Weinhold, N., Suter, A-A., Stoltenburg, C., Neugebauer, J., Kallinich, T., Kaindl, A. M., Holzhauer, S., Bührer, C., Bufler, P., Kornak, U., Ott, C-E., Schülke, M., Nguyen, H. H. P., Hoffjan, S., Grasemann, C., Rothoeft, T., Brinkmann, F., Matar, N., Sivalingam, S., Perne, C., Mangold, E., Kreiss, M., Cremer, K., Betz, R. C., Mücke, M., Grigull, L., Klockgether, T., Spier, I., Heimbach, A., Bender, T., Brand, F., Stieber, C., Morawiec, A. M., Karakostas, P., Schäfer, V. S., Bernsen, S., Weydt, P., Castro-Gomez, S., Aziz, A., Grobe-Einsler, M., Kimmich, O., Kobeleva, X., Önder, D., Lesmann, H., Kumar, S., Tacik, P., Basin, M. A., Incardona, P., Lee-Kirsch, M. A., Berner, R., Schuetz, C., Körholz, J., Kretschmer, T., Di Donato, N., Schröck, E., Heinen, A., Reuner, U., Hanßke, A-M., Kaiser, F. J., Manka, E., Munteanu, M., Kuechler, A., Cordula, K., Hirtz, R., Schlapakow, E., Schlein, C., Lisfeld, J., Kubisch, C., Herget, T., Hempel, M., Weiler-Normann, C., Ullrich, K., Schramm, C., Rudolph, C., Rillig, F., Groffmann, M., Muntau, A., Tibelius, A., Schwaibold, E. M. C., Schaaf, C. P., Zawada, M., Kaufmann, L., Hinderhofer, K., Okun, P. M., Kotzaeridou, U., Hoffmann, G. F., Choukair, D., Bettendorf, M., Spielmann, M., Ripke, A., Pauly, M., Münchau, A., Lohmann, K., Hüning, I., Hanker, B., Bäumer, T., Herzog, R., Hellenbroich, Y., Westphal, D. S., Strom, T., Kovacs, R., Riedhammer, K. M., Mayerhanser, K., Graf, E., Brugger, M., Hoefele, J., Oexle, K., Mirza-Schreiber, N., Berutti, R., Schatz, U., Krenn, M., Makowski, C., Weigand, H., Schröder, S., Rohlfs, M., Vill, K., Hauck, F., Borggraefe, I., Müller-Felber, W., Kurth, I., Elbracht, M., Knopp, C., Begemann, M., Kraft, F., Lemke, J. R., Hentschel, J., Platzer, K., Strehlow, V., Abou Jamra, R., Kehrer, M., Demidov, G., Beck-Wödl, S., Graessner, H., Sturm, M., Zeltner, L., Schöls, L. J., Magg, J., Bevot, A., Kehrer, C., Kaiser, N., Turro, E., Horn, D., Grüters-Kieslich, A., Klein, C., Mundlos, S., Nöthen, M., Riess, O., Meitinger, T., Krude, H., Krawitz, P. M., Haack, T., Ehmke, N. & Wagner, M., 08.2024, In: NAT GENET. 56, 8, p. 1644-1653 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
Schlein, C., Talukdar, S., Heine, M., Fischer, A. W., Krott, L. M., Nilsson, S. K., Brenner, M. B., Heeren, J. & Scheja, L., 08.03.2016, In: CELL METAB. 23, 3, p. 441-53 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Implications of thermogenic adipose tissues for metabolic health
Schlein, C. & Heeren, J., 08.2016, In: BEST PRACT RES CL EN. 30, 4, p. 487-496 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
Schlein, C., Fischer, A. W., Sass, F., Worthmann, A., Tödter, K., Jaeckstein, M. Y., Behrens, J., Lynes, M. D., Kiebish, M. A., Narain, N. R., Bussberg, V., Jespersen, N. Z., Nielsen, S., Scheele, C., Schweizer, M., Braren, I., Bartelt, A., Tseng, Y-H., Heeren, J. & Scheja, L., 12.01.2021, In: CELL REP. 34, 2, p. 108624Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
TFEB-deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality
Sass, F., Schlein, C., Jaeckstein, M. Y., Pertzborn, P., Schweizer, M., Schinke, T., Ballabio, A., Scheja, L., Heeren, J. & Fischer, A. W., 05.2021, In: MOL METAB. 47, p. 101173Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
Poch, T., Bahn, J., Casar, C., Krause, J., Evangelakos, I., Gilladi, H., Kunzmann, L. K., Laschtowitz, A., Iuso, N., Schäfer, A-M., Liebig, L. A., Steinmann, S., Sebode, M., Folseraas, T., Engesæter, L. K., Karlsen, T. H., Franke, A., Metabolic Sciences, Max Delbrück Centre for Molecular Medicine in the Helmholtz Association, C., Schlein, C., Galun, E., Huber, S., Lohse, A. W., Gagliani, N., Schwinge, D. & Schramm, C., 16.07.2024, In: CELL REP MED. 5, 7, p. 101620Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Niemann, B., Haufs-Brusberg, S., Puetz, L., feickert, M., Jaeckstein, M. Y., Hoffmann, A., Zurkovic, J., Heine, M., Trautmann, E-M., Müller, CE., Tönies, A., Schlein, C., Jafari, A., Eltzsching, H. K., Gnad, T., Blüher, M., Krahmer, N., Kovacs, P., Heeren, J. & Pfeifer, A., 08.09.2022, In: NATURE. 609, 7926, p. 361–368 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
FoxO transcription factors are required for hepatic HDL-cholesterol clearance
Lee, S. X., Heine, M., Schlein, C., Ramakrishnan, R., Liu, J., Belnavis, G., Haimi, I., Fischer, A. W., Ginsberg, H., Heeren, J., Rinninger, F. & Haeusler, R. A., 02.04.2018, In: J CLIN INVEST. 128, 4, p. 1615-1626 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors
Kraef, C., Schlein, C., Hiller, J., Westhölter, D., Denzer, U., Horvatits, T., Peine, S., Lohse, A. W., Lütgehetmann, M., Polywka, S. & Pischke, S., 08.2018, In: J CLIN VIROL. 105, p. 26-30 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice
Heine, M., Fischer, A. W., Schlein, C., Jung, C., Straub, L. G., Gottschling, K., Mangels, N., Yuan, Y., Nilsson, S. K., Liebscher, G., Chen, O., Schreiber, R., Zechner, R., Scheja, L. & Heeren, J., 02.10.2018, In: CELL METAB. 28, 4, p. 644-655.e4Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Intact innervation is essential for diet-induced recruitment of brown adipose tissue
Fischer, A. W., Schlein, C., Cannon, B., Heeren, J. & Nedergaard, J., 01.03.2019, In: AM J PHYSIOL-ENDOC M. 316, 3, p. E487-E503Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation
Fischer, A. W., Jaeckstein, M. Y., Gottschling, K., Heine, M., Sass, F., Mangels, N., Schlein, C., Worthmann, A., Bruns, O. T., Yuan, Y., Zhu, H., Chen, O., Ittrich, H., Nilsson, S. K., Stefanicka, P., Ukropec, J., Balaz, M., Dong, H., Sun, W., Reimer, R., Scheja, L. & Heeren, J., 02.03.2021, In: CELL METAB. 33, 3, p. 547-564.e7Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue's Competence for Cold-Induced Thermogenic Recruitment
Fischer, A. W., de Jong, J. M. A., Sass, F., Schlein, C., Heeren, J. & Petrovic, N., 2020, In: FRONT ENDOCRINOL. 11, p. 568682Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice
Fischer, A. W., Behrens, J., Sass, F., Schlein, C., Heine, M., Pertzborn, P., Scheja, L. & Heeren, J., 11.2020, In: J LIPID RES. 61, 11, p. 1377-1389 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles
Fischer, A. W., Albers, K., Schlein, C., Sass, F., Krott, L. M., Schmale, H., Gordts, P. L. S. M., Scheja, L. & Heeren, J., 01.06.2019, In: BBA-MOL BASIS DIS. 1865, 6, p. 1592-1603 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice
Evangelakos, I., Kuhl, A., Baguhl, M., Schlein, C., John, C., Rohde, J. K., Heine, M. & Worthmann, A-F., 11.04.2022, In: FRONT CELL DEV BIOL. 10, 10, p. 836741 836741.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity
Chen, Y., Buyel, J. J., Hanssen, M. J. W., Siegel, F., Pan, R., Naumann, J., Schell, M., van der Lans, A., Schlein, C., Froehlich, H., Heeren, J., Virtanen, K. A., van Marken Lichtenbelt, W. & Pfeifer, A., 2016, In: NAT COMMUN. 7, p. 11420Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., Jung, C., Vazirpanah, N., Brouwers, L. P. J., Gordts, P. L. S. M., Esko, J. D., Hiemstra, P. S., Havekes, L. M., Scheja, L., Heeren, J. & Rensen, P. C. N., 2015, In: NAT COMMUN. 6, p. 6356Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
Bartelt, A., John, C., Schaltenberg, N., Berbée, J. F. P., Worthmann, A., Cherradi, M. L., Schlein, C., Piepenburg, J., Boon, M. R., Rinninger, F., Heine, M., Toedter, K., Niemeier, A., Nilsson, S. K., Fischer, M., Wijers, S. L., van Marken Lichtenbelt, W. D., Scheja, L., Rensen, P. C. N. & Heeren, J., 19.04.2017, In: NAT COMMUN. 8, p. Art. 15010Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
Bartelt, A., Widenmaier, S. B., Schlein, C., Johann, K., Goncalves, R. L. S., Eguchi, K., Fischer, A. W., Parlakgül, G., Snyder, N. A., Nguyen, T. B., Bruns, O. T., Franke, D., Bawendi, M. G., Lynes, M. D., Leiria, L. O., Tseng, Y-H., Inouye, K. E., Arruda, A. P. & Hotamisligil, G. S., 03.2018, In: NAT MED. 24, 3, p. 292-303 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant
Albers, K., Schlein, C., Wenner, K., Lohse, P., Bartelt, A., Heeren, J., Santer, R. & Merkel, M., 01.03.2014, In: ATHEROSCLEROSIS. 233, 1, p. 97-103 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review