Research ExplorerScientific StaffBabett Steglich Publications

Dr.phil. ID: 2597790

Babett Steglich

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Affiliations
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Publications

  1. 2024

  2. Protective function of sclerosing cholangitis on IBD

    Bedke, T., Stumme, F., Tomczak, M., Steglich, B., Jia, R., Bohmann, S., Wittek, A., Kempski, J., Göke, E., Böttcher, M., Reher, D., Franke, A., Lennartz, M., Clauditz, T., Sauter, G., Fründt, T., Weidemann, S., Tiegs, G., Schramm, C., Gagliani, N., Pelczar, P. & Huber, S., 11.07.2024, In: GUT. 73, 8, p. 1292-1301 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. A Gradient of Intestinal Inflammation in Primary Sclerosing Cholangitis

    Wittek, A., Steglich, B., Casar, C., Seiz, O., Huber, P., Ehlken, H., Reher, D., Wende, S., Bedke, T., Kempski, J., Böttcher, M., Bang, C., Thingholm, L., Krech, T., Lohse, A. W., Sauter, G., Rösch, T., Franke, A., Schramm, C., Gagliani, N., Pelczar, P. & Huber, S., 03.06.2024, In: INFLAMM BOWEL DIS. 30, 6, p. 900-910 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction

    Shiri, A. M., Zhang, T., Bedke, T., Zazara, D. E., Zhao, L., Lücke, J., Sabihi, M., Fazio, A., Zhang, S., Tauriello, D. V. F., Batlle, E., Steglich, B., Kempski, J., Agalioti, T., Nawrocki, M., Xu, Y., Riecken, K., Liebold, I., Brockmann, L., Konczalla, L., Bosurgi, L., Mercanoglu, B., Seeger, P., Küsters, N., Lykoudis, P. M., Heumann, A., Arck, P. C., Fehse, B., Busch, P., Grotelüschen, R., Mann, O., Izbicki, J. R., Hackert, T., Flavell, R. A., Gagliani, N., Giannou, A. D. & Huber, S., 04.2024, In: J HEPATOL. 80, 4, p. 634-644 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. A protective effect of inflammatory bowel disease on the severity of sclerosing cholangitis

    Stumme, F., Steffens, N., Steglich, B., Mathies, F., Nawrocki, M., Sabihi, M., Soukou-Wargalla, S., Göke, E., Kempski, J., Fründt, T., Weidemann, S., Schramm, C., Gagliani, N., Huber, S. & Bedke, T., 06.03.2024, In: FRONT IMMUNOL. 15, p. 1307297

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. 2023

  7. Tr1 Cells Emerge and Suppress Effector Th17 Cells in Glomerulonephritis

    Soukou-Wargalla, S., Kilian, C., Velasquez, L. N., Machicote, A., Letz, P., Tran, H. B., Domanig, S., Bertram, F., Stumme, F., Bedke, T., Giannou, A., Kempski, J., Sabihi, M., Song, N., Paust, H-J., Borchers, A., Garcia Perez, L., Pelczar, P., Liu, B., Ergen, C., Steglich, B., Muscate, F., Huber, T. B., Panzer, U., Gagliani, N., Krebs, C. F. & Huber, S., 01.12.2023, In: J IMMUNOL. 211, 11, p. 1669-1679 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Short-term dietary changes can result in mucosal and systemic immune depression

    Siracusa, F., Schaltenberg, N., Kumar, Y., Lesker, T. R., Steglich, B., Liwinski, T., Cortesi, F., Frommann, L., Diercks, B-P., Bönisch, F., Fischer, A. W., Scognamiglio, P., Pauly, M. J., Casar, C., Cohen, Y., Pelczar, P., Agalioti, T., Delfs, F., Worthmann, A., Wahib, R., Jagemann, B., Mittrücker, H-W., Kretz, O., Guse, A. H., Izbicki, J. R., Lassen, K. G., Strowig, T., Schweizer, M., Villablanca, E. J., Elinav, E., Huber, S., Heeren, J. & Gagliani, N., 09.2023, In: NAT IMMUNOL. 24, 9, p. 1473-1486 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury

    Hackstein, C-P., Spitzer, J., Symeonidis, K., Horvatic, H., Bedke, T., Steglich, B., Klein, S., Assmus, L. M., Odainic, A., Szlapa, J., Kessler, N., Beyer, M., Schmithausen, R., Latz, E., Flavell, R. A., Garbi, N., Kurts, C., Kümmerer, B. M., Trebicka, J., Roers, A., Huber, S., Schmidt, S. V., Knolle, P. A. & Abdullah, Z., 07.2023, In: J HEPATOL. 79, 1, p. 150-166 17 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

    Giannou, A. D., Kempski, J., Shiri, A. M., Lücke, J., Zhang, T., Zhao, L., Zazara, D. E., Cortesi, F., Riecken, K., Amezcua Vesely, M. C., Low, J. S., Xu, H., Kaffe, E., Garcia-Perez, L., Agalioti, T., Yamada, Y., Jungraithmayr, W., Zigmond, E., Karstens, K-F., Steglich, B., Wagner, J., Konczalla, L., Carambia, A., Schulze, K., von Felden, J., May, P., Briukhovetska, D., Bedke, T., Brockmann, L., Starzonek, S., Lange, T., Koch, C., Riethdorf, S., Pelczar, P., Böttcher, M., Sabihi, M., Huber, F. J., Reeh, M., Grass, J. K., Wahib, R., Seese, H., Stüben, B-O., Fard-Aghaie, M., Duprée, A., Scognamiglio, P., Plitzko, G., Meiners, J., Soukou, S., Wittek, A., Manthey, C., Maroulis, I. C., Arck, P. C., Perez, D., Gao, B., Zarogiannis, S. G., Strowig, T., Pasqualini, R., Arap, W., Gosálvez, J. S., Kobold, S., Prinz, I., Guse, A. H., Tachezy, M., Ghadban, T., Heumann, A., Li, J., Melling, N., Mann, O., Izbicki, J. R., Pantel, K., Schumacher, U., Lohse, A. W., Flavell, R. A., Gagliani, N. & Huber, S., 10.01.2023, In: IMMUNITY. 56, 1, p. 125-142.e12

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. 2022

  12. A Critical Role of the IL-22-IL-22 Binding Protein Axis in Hepatocellular Carcinoma

    Giannou, A. D., Lücke, J., Kleinschmidt, D., Shiri, A. M., Steglich, B., Nawrocki, M., Zhang, T., Zazara, D. E., Kempski, J., Zhao, L., Giannou, O., Agalioti, T., Brockmann, L., Bertram, F., Sabihi, M., Böttcher, M., Ewald, F., Schulze, K., von Felden, J., Machicote, A., Maroulis, I. C., Arck, P. C., Graß, J-K., Mercanoglu, B., Reeh, M., Wolter, S., Tachezy, M., Seese, H., Theodorakopoulou, M., Lykoudis, P. M., Heumann, A., Uzunoglu, F. G., Ghadban, T., Mann, O., Izbicki, J. R., Li, J., Duprée, A., Melling, N., Gagliani, N. & Huber, S., 07.12.2022, In: CANCERS. 14, 24, 6019.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. 2021

  14. Efferocytosis fuels malignant pleural effusion through TIMP1

    Zhao, L., Giannou, A. D., Xu, Y., Shiri, A. M., Liebold, I., Steglich, B., Bedke, T., Zhang, T., Lücke, J., Scognamiglio, P., Kempski, J., Woestemeier, A., Chen, J., Agalioti, T., Zazara, D. E., Lindner, D., Janning, M., Hennigs, J. K., Jagirdar, R. M., Kotsiou, O. S., Zarogiannis, S. G., Kobayashi, Y., Izbicki, J. R., Ghosh, S., Rothlin, C. V., Bosurgi, L., Huber, S. & Gagliani, N., 08.2021, In: SCI ADV. 7, 33, eabd6734.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. 2020

  16. Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

    Perez, L. G., Kempski, J., McGee, H. M., Pelzcar, P., Agalioti, T., Giannou, A., Konczalla, L., Brockmann, L., Wahib, R., Xu, H., Vesely, M. C. A., Soukou, S., Steglich, B., Bedke, T., Manthey, C., Seiz, O., Diercks, B-P., Gnafakis, S., Guse, A. H., Perez, D., Izbicki, J. R., Gagliani, N., Flavell, R. A. & Huber, S., 06.11.2020, In: NAT COMMUN.

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  17. IL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans

    Kempski, J., Giannou, A. D., Riecken, K., Zhao, L., Steglich, B., Lücke, J., Garcia-Perez, L., Karstens, K-F., Wöstemeier, A., Nawrocki, M., Pelczar, P., Witkowski, M., Nilsson, S., Konczalla, L., Shiri, A. M., Kempska, J., Wahib, R., Brockmann, L., Huber, P., Gnirck, A-C., Turner, J-E., Zazara, D. E., Arck, P. C., Stein, A., Simon, R., Daubmann, A., Meiners, J., Perez, D., Strowig, T., Koni, P., Kruglov, A. A., Sauter, G., Izbicki, J. R., Guse, A. H., Roesch, T., Lohse, A. W., Flavell, R. A., Gagliani, N. & Huber, S., 10.2020, In: GASTROENTEROLOGY. 159, 4, p. 1417-1430.e3

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Therapeutic Targeting of Myeloperoxidase Attenuates NASH in Mice

    Koop, A., Thiele, N. D., Steins, D., Michaëlsson, E., Wehmeyer, M., Scheja, L., Steglich, B., Huber, S., Schulze zur Wiesch, J., Lohse, A. W., Heeren, J. & Kluwe, J., 29.07.2020, In: HEPATOL COMMUN. 4, 10, p. 1441-1458 18 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. The induction and function of the anti-inflammatory fate of TH17 cells

    Xu, H., Agalioti, T., Zhao, J., Steglich, B., Wahib, R., Vesely, M. C. A., Bielecki, P., Bailis, W., Jackson, R., Perez, D., Izbicki, J., Licona-Limón, P., Kaartinen, V., Geginat, J., Esplugues, E., Tolosa, E., Huber, S., Flavell, R. A. & Gagliani, N., 03.07.2020, In: NAT COMMUN. 11, 1, p. 3334

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Anti-inflammatory microenvironment of esophageal adenocarcinomas negatively impacts survival

    Karstens, K-F., Kempski, J., Giannou, A. D., Pelczar, P., Steglich, B., Steurer, S., Freiwald, E., Woestemeier, A., Konczalla, L., Tachezy, M., Reeh, M., Bockhorn, M., Perez, D., Mann, O., Lohse, A. W., Roesch, T., Izbicki, J. R., Gagliani, N. & Huber, S., 06.2020, In: CANCER IMMUNOL IMMUN. 69, 6, p. 1043-1056 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

    Perez, L. G., Kempski, J., M McGee, H., Pelzcar, P., Agalioti, T., Giannou, A., Konczalla, L., Brockmann, L., Wahib, R., Xu, H., Vesely, M. C. A., Soukou, S., Steglich, B., Bedke, T., Manthey, C., Seiz, O., Diercks, B-P., Gnafakis, S., Guse, A. H., Perez, D., Izbicki, J. R., Gagliani, N., Flavell, R. A. & Huber, S., 25.05.2020, In: NAT COMMUN. 11, 1

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. 2018

  23. Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

    Brockmann, L., Soukou, S., Steglich, B., Czarnewski, P., Zhao, L., Wende, S., Bedke, T., Ergen, C., Manthey, C., Agalioti, T., Geffken, M., Seiz, O., Parigi, S. M., Sorini, C., Geginat, J., Fujio, K., Jacobs, T., Roesch, T., Izbicki, J. R., Lohse, A. W., Flavell, R. A., Krebs, C., Gustafsson, J-A., Antonson, P., Roncarolo, M. G., Villablanca, E. J., Gagliani, N. & Huber, S., 21.12.2018, In: NAT COMMUN. 9, 1, p. 5457

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice

    Wolters-Eisfeld, G., Mercanoglu, B., Hofmann, B. T., Wolpers, T., Schnabel, C., Harder, S., Steffen, P., Bachmann, K. A., Steglich, B., Schrader, J., Gagliani, N., Schlüter, H., Güngör, C., Izbicki, J., Wagener, C. & Bockhorn, M., 10.10.2018, In: EXP MOL MED. 50, 10, p. 1-13 13 p., 133.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. 2017

  26. A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury

    Kleinschmidt, D., Giannou, A. D., McGee, H. M., Kempski, J., Steglich, B., Huber, F. J., Ernst, T. M., Shiri, A. M., Wegscheid, C., Tasika, E., Hübener, P., Huber, P., Bedke, T., Steffens, N., Agalioti, T., Fuchs, T., Noll, J., Lotter, H., Tiegs, G., Lohse, A. W., Axelrod, J. H., Galun, E., Flavell, R. A., Gagliani, N. & Huber, S., 12.2017, In: J IMMUNOL. 199, 12, p. 4078-4090

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo

    Brockmann, L., Gagliani, N., Steglich, B., Giannou, A. D., Kempski, J., Pelczar, P., Geffken, M., Mfarrej, B., Huber, F., Herkel, J., Wan, Y. Y., Esplugues, E., Battaglia, M., Krebs, C. F., Flavell, R. A. & Huber, S., 01.02.2017, In: J IMMUNOL. 198, 3, p. 1130-1141

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review