Research ExplorerResearch UnitsInstitute of Anatomy and Experimental Morphology Publications

Institute of Anatomy and Experimental Morphology

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Publications

  1. Vascular dysfunction as an additional pathomechanism in glutaric aciduria type I

    Mühlhausen, C., Ergün, S., Strauss, K. A., Koeller, D. M., Crnic, L., Woontner, M., Goodman, S. I., Ullrich, K. & Braulke, T., 2004, In: J INHERIT METAB DIS. 27, 6, p. 829-34 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  2. GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy

    Mukha, A., Kahya, U., Linge, A., Chen, O., Löck, S., Lukiyanchuk, V., Richter, S., Alves, T. C., Peitzsch, M., Telychko, V., Skvortsov, S., Negro, G., Aschenbrenner, B., Skvortsova, I-I., Mirtschink, P., Lohaus, F., Hölscher, T., Neubauer, H., Rivandi, M., Labitzky, V., Lange, T., Franken, A., Behrens, B., Stoecklein, N. H., Toma, M., Sommer, U., Zschaeck, S., Rehm, M., Eisenhofer, G., Schwager, C., Abdollahi, A., Groeben, C., Kunz-Schughart, L. A., Baretton, G. B., Baumann, M., Krause, M., Peitzsch, C. & Dubrovska, A., 2021, In: THERANOSTICS. 11, 16, p. 7844-7868 25 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Cyclic GMP signaling in rat urinary bladder, prostate, and epididymis: tissue-specific changes with aging and in response to Leydig cell depletion.

    Müller, D., Mukhopadhyay, A. K., Davidoff, M. & Middendorff, R., 2011, In: REPRODUCTION. 142, 2, p. 333-343 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Expression of sphingosine-1-phosphate receptors and lysophosphatidic acid receptors on cultured and xenografted human colon, breast, melanoma, and lung tumor cells.

    Müller, R., Berliner, C., Leptin, J., Pörtner, D., Bialecki, W., Kleuser, B., Schumacher, U., Evi, M. & Novica, M., 2010, In: TUMOR BIOL. 31, 4, p. 341-349 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Granulomatous Inflammation in ANCA-Associated Vasculitis

    Müller, A., Krause, B., Kerstein-Stähle, A., Comdühr, S., Klapa, S., Ullrich, S., Holl-Ulrich, K. & Lamprecht, P., 17.06.2021, In: INT J MOL SCI. 22, 12, 6474.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  6. Evidence for two recA genes mediating DNA repair in Bacillus megaterium.

    Nahrstedt, H., Schröder, C. & Meinhardt, F., 2005, In: MICROBIOL-SGM. 151, 3, p. 775-787 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models

    Navarra, M., Ursino, M. R., Ferlazzo, N., Russo, M., Schumacher, U. & Valentiner, U., 01.06.2014, In: FITOTERAPIA. 95, p. 83-92 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Mistletoe lectin binds to multidrug resistance-associated protein MRP5.

    Nehmann, N., Schade Ulrika, M., Pfüller, U., Schachner, M. & Schumacher, U., 2009, In: ANTICANCER RES. 29, 12, p. 4941-4948 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Comparison of two techniques for the screening of human tumor cells in mouse blood: Quantitative real-time polymerase chain reaction (qRT-PCR) versus laser scanning cytometry (LSC).

    Nehmann, N., Wicklein, D., Schumacher, U. & Müller, R., 2010, In: ACTA HISTOCHEM. 112, 5, p. 489-96

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. Low expression of CD24 is associated with poor survival in colorectal cancer

    Nersisyan, S., Ahlers, A-K., Lange, T., Wicklein, D., Galatenko, A., Bohnenberger, H., Elakad, O., Conradi, L-C., Genduso, S., Maar, H., Schiecke, A., Maltseva, D., Raygorodskaya, M., Makarova, J., Schumacher, U. & Tonevitsky, A., 01.2022, In: BIOCHIMIE. 192, p. 91-101 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. In Vitro Model for Studying of the Role of IGFBP6 Gene in Breast Cancer Metastasizing

    Nikulin, S. V., Raigorodskaya, M. P., Poloznikov, A. A., Zakharova, G. S., Schumacher, U., Wicklein, D., Stürken, C., Riecken, K., Fomicheva, K. A., Alekseev, B. Y. & Shkurnikov, M. Y., 03.2018, In: B EXP BIOL MED+. 164, 5, p. 688-692 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes

    Nikulin, S. V., Raigorodskaya, M. P., Poloznikov, A. A., Zakharova, G. S., Schumacher, U., Wicklein, D., Stürken, C., Riecken, K., Fomicheva, K. A., Alekseev, B. Y. & Shkurnikov, M. Y., 03.2018, In: B EXP BIOL MED+. 164, 5, p. 650-654 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3'-diindolylmethane and chemotherapy drugs

    Nikulin, S. V., Alekseev, B. Y., Sergeeva, N. S., Karalkin, P. A., Nezhurina, E. K., Kirsanova, V. A., Sviridova, I. K., Akhmedova, S. A., Volchenko, N. N., Bolotina, L. V., Osipyants, A. I., Hushpulian, D. M., Topchiy, M. A., Asachenko, A. F., Koval, A. P., Shcherbo, D. S., Kiselev, V. I., Mikhaylenko, D. S., Schumacher, U. & Poloznikov, A. A., 12.2020, In: BIOCHIMIE. 179, p. 217 - 227 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. Effect of the Expression of ELOVL5 and IGFBP6 Genes on the Metastatic Potential of Breast Cancer Cells

    Nikulin, S., Zakharova, G., Poloznikov, A., Raigorodskaya, M., Wicklein, D., Schumacher, U., Nersisyan, S., Bergquist, J., Bakalkin, G., Astakhova, L. & Tonevitsky, A., 2021, In: FRONT GENET. 12, 662843.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime.

    Nurulain, S. M., Lorke, D., Hasan, M. Y., Shafiullah, M., Kuca, K., Musilek, K. & Petroianu, G. A., 2009, In: NEUROTOX RES. 16, 1, p. 60-67 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. AB0/Rhesus Blood Group Does Not Influence Clinicopathological Tumor Characteristics or Oncological Outcome in Patients Undergoing Radical Prostatectomy

    Oh, S. J., Mandel, P., Chun, F. K. H., Tennstedt, P., Peine, S., Hohenhorst, J. L., Hiller, J., Graefen, M., Tilki, D. & Steuber, T., 2017, In: FRONT SURG. 4, p. 75

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo

    Oh-Hohenhorst, S. J., Tilki, D., Ahlers, A-K., Suling, A., Hahn, O., Tennstedt, P., Matuszcak, C., Maar, H., Labitzky, V., Hanika, S., Starzonek, S., Baumgart, S., Johnsen, S. A., Kluth, M., Sirma, H., Simon, R., Sauter, G., Huland, H., Schumacher, U. & Lange, T., 01.2022, In: CANCER GENE THER. 29, 1, p. 49-61 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Role of Metastasis-Related microRNAs in Prostate Cancer Progression and Treatment

    Oh-Hohenhorst, S. J. & Lange, T., 06.09.2021, In: CANCERS. 13, 17

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  19. c-FOS suppresses ovarian cancer progression by changing adhesion

    Oliveira Ferrer, L., Rößler, K., Haustein, V., Schröder, C., Wicklein, D., Maltseva, D., Khaustova, N., Samatov, T., Tonevitsky, A., Mahner, S., Jänicke, F., Schumacher, U. & Milde-Langosch, K., 04.02.2014, In: BRIT J CANCER. 110, 3, p. 753-63 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Prognostic impact of transcription factor Fra-1 in ER-positive breast cancer: contribution to a metastatic phenotype through modulation of tumor cell adhesive properties

    Oliveira-Ferrer, L., Kürschner, M., Labitzky, V., Wicklein, D., Müller, V., Lüers, G., Schumacher, U., Milde-Langosch, K. & Schröder, C., 10.2015, In: J CANCER RES CLIN. 141, 10, p. 1715-26

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Ovarian Cancer-Cell Pericellular Hyaluronan Deposition Negatively Impacts Prognosis of Ovarian Cancer Patients

    Oliveira-Ferrer, L., Schmalfeldt, B., Dietl, J., Bartmann, C., Schumacher, U. & Stürken, C., 16.11.2022, In: BIOMEDICINES. 10, 11, 2944.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression.

    Otto, B., Gruner, K., Heinlein, C., Wegwitz, F., Nollau, P., Ylstra, B., Pantel, K., Schumacher, U., Baumbusch, L. O., Martin-Subero, J. I., Siebert, R., Wagener, C., Streichert, T., Deppert, W. & Tolstonog, G. V., 2013, In: INT J CANCER. 132, 6, p. 1300-1310 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. Molecular changes in pre-metastatic lymph nodes of esophageal cancer patients

    Otto, B., Koenig, A. M., Tolstonog, G. V., Jeschke, A., Klätschke, K., Vashist, Y. K., Wicklein, D., Wagener, C., Izbicki, J. R. & Streichert, T., 21.07.2014, In: PLOS ONE. 9, 7, p. e102552

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. Methylene blue and Alzheimer's disease.

    Oz, M., Lorke, D. & Petroianu, G. A., 2009, In: BIOCHEM PHARMACOL. 78, 8, p. 927-932 8.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. Cellular and molecular actions of methylene blue in the nervous system.

    Oz, M., Lorke, D., Hasan, M. & Petroianu, G. A., 2009, In: MED RES REV.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy

    Paavola, J., Schliffke, S., Rossetti, S., Kuo, I. Y-T., Yuan, S., Sun, Z., Harris, P. C., Torres, V. E. & Ehrlich, B. E., 01.05.2013, In: J MOL CELL CARDIOL. 58, p. 199-208 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. Integration of periorbital titanium implants in irradiated bone: case report and histologic evaluation

    Pack, M., Röser, K. & Eufinger, H., 23.04.1999, In: The International journal of oral & maxillofacial implants. 14, 2, p. 290-4 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. Angiotensin Inhibition, TGF-β and EMT in Cancer

    Pallasch, F. B. & Schumacher, U., 28.09.2020, In: CANCERS. 12, 10

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  29. The Histogenetic Origin of Malignant Cells Predicts Their Susceptibility towards Synthetic Lethality Utilizing the TK.007 System

    Pallasch, F. B., Freytag, V., Kriegs, M., Gatzemeier, D., Mair, T., Voss, H., Riecken, K., Dawood, M., Fehse, B., Efferth, T., Schlüter, H. & Schumacher, U., 19.06.2024, In: CANCERS. 16, 12, 2278.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. Expression of nuclear lamins in mammalian somatic cells lacking cytoplasmic intermediate filament proteins

    Paulin-Levasseur, M., Scherbarth, A., Giese, G., Röser, K., Bohn, W. & Traub, P., 03.1989, In: J CELL SCI. 92 ( Pt 3), p. 361-70 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Biological and molecular characterization of a new human ampullary cancer cell line

    Peiper, M., Alldinger, I., Heller, R., Pilarsky, C., Schumacher, U., Knoefel, W-T., Heinecke, A. & Izbicki, J. R., 12.04.2003, In: ANTICANCER RES. 23, 1A, p. 291-8 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Quantitative MR imaging of targeted SPIO particles on the cell surface and comparison to flow cytometry.

    Peldschus, K., Schultze, A., Nollau, P., Kaul, M., Schumacher, U., Wagener, C., Adam, G. & Ittrich, H., 2010, In: MAGN RESON IMAGING. 28, 4, p. 599-606 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Interaction of magnetically labeled multipotent mesenchymal stromal cells and E-and P-selectins monitored by magnetic resonance imaging in mice

    Peldschus, K., Salamon, J., Wicklein, D., Lange, C., Ittrich, H., Adam, G. & Schumacher, U., 2013, In: MOL IMAGING. 12, 2, p. 100-10 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Phl p 3: structural and immunological characterization of a major allergen of timothy grass pollen.

    Petersen, A., Suck, R., Lindner, B., Georgieva, D., Ernst, M., Notbohm, H., Wicklein, D., Cromwell, O. & Becker, W-M., 2006, In: CLIN EXP ALLERGY. 36, 6, p. 840-849 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. Comparative study of wound healing in rat skin following incision with a novel picosecond infrared laser (PIRL) and different surgical modalities

    Petersen, H., Tavakoli, F., Kruber, S., Münscher, A., Gliese, A., Hansen, N-O., Uschold, S., Eggert, D., Robertson, W. D., Gosau, T., Sehner, S., Kwiatkowski, M., Schlüter, H., Schumacher, U., Knecht, R. & Miller, R. J. D., 2016, In: LASER SURG MED. 48, 4, p. 385-91

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. Picosecond Infrared Laser (PIRL) Application in Stapes Surgery-First Experience in Human Temporal Bones

    Petersen, H., Gliese, A., Stober, Y., Maier, S., Hansen, N-O., Kruber, S., Eggert, D., Tóth, M., Gosau, T., Schlüter, H., Püschel, K., Schumacher, U., Miller, R. J. D., Münscher, A. & Dalchow, C., 04.2018, In: OTOL NEUROTOL. 39, 4, p. e224-e230

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. Pyridinium oxime reactivators of cholinesterase inhibited by diisopropyl-fluorophosphate (DFP): predictive value of in-vitro testing for in-vivo efficacy.

    Petroianu, G. A. & Lorke, D., 2008, In: MINI-REV MED CHEM. 8, 13, p. 1328-1342 13.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  38. Die Mistellektine als wirksamkeitsmitbestimmende Bestandteile von Mistelextrakten

    Pfüller, U. & Schumacher, U., 2013, Die Mistel in der Tumortherapie 3 - Aktueller Stand der Forschung und klinische Anwendung. Scheer, R., Alban, S., Becker, H., Blaschek, W., Kemper, F. H., Kreis, W., Matthes, H., Schilcher, H. & Stange, R. (eds.). 1 ed. Essen: KVC Verlag, p. 3 - 12 10 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  39. Selektive Inaktivierung der B-Untereinheit der Mistellektine und anderer RIP-II-Lektine in ionischen Flüssigkeiten

    Pfüller, U. & Pfüller, K., 2013, Die Mistel in der Tumortherapie 3 - Aktueller Stand der Forschung und klinische Anwendung. Scheer, R., Alban, S., Becker, H., Blaschek, W., Kemper, F. H., Kreis, W., Matthes, H., Schilcher, H. & Stange, R. (eds.). 1 ed. KVC Verlag, p. 37-44 8 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  40. Das Lektin- und Viscotoxin-Spektrum der Europäischen Mistel: Isolierung und Quantifizierung der Mistellektine, ihrer Untereinheiten und der Viscotoxine

    Pfüller, U. & Schumacher, U., 2016, Die Mistel in der Tumortherapie: Aktueller Stand der Forschung und klinische Anwendung. Scheer, R., Alban, S., Becker, H., Blaschek, W., Kreis, W., Matthes, H., Schilcher, H., Stange, R., Beer, A-M. & Spahn, G. (eds.). 1 ed. Essen: KVC Verlag, Vol. 4. p. 61-76 16 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  41. Naturapotheke Mistel: Ein immergrüner Halbparasit in der Onkologie

    Pfüller, U. & Stürken, C., 2017, In: Biol. Unserer Zeit. 47, 4, p. 240 - 244

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. Lektine, Viscotoxine und biologisch aktive niedermolekulare Bestandteile wässriger Mistelextrakte

    Pfüller, U. & Schumacher, U., 2020, Die Mistel in der Tumortherapie 5: Aktueller Stand der Forschung und klinische Anwendung. Scheer, R., Alban, S., Becker, H., Beer, A-M., Blaschek, W., Klein, R., Kreis, W., Leneweit, G., Matthes, H., Spahn, G. & Stange, R. (eds.). 1 ed. 2020: KVC Verlag, p. 17 - 22 6 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  43. Selektive Inaktivierung der zuckerbindenden B-Untereinheit von RIP-II-Lektinen einschließlich Mistellektinen unter Erhalt der zytotoxischen A-Kette in "grünen Lösungsmitteln" - ionischen Flüssigkeiten

    Pfüller, U., Pfüller, K. & Schumacher, U., 2020, Die Mistel in der Tumortherapie 5: Aktueller Stand der Forschung und klinische Anwendung. Scheer, R., Alban, S., Becker, H., Beer, A-M., Blaschek, W., Klein, R., Kreis, W., Leneweit, G., Matthes, H., Spahn, G. & Stange, R. (eds.). 1 ed. 2020: KVC Verlag, p. 23 - 27 5 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  44. Epithelial and Mesenchymal-like Pancreatic Cancer Cells Exhibit Different Stem Cell Phenotypes Associated with Different Metastatic Propensities

    Philipp, L-M., Yesilyurt, U-U., Surrow, A., Künstner, A., Mehdorn, A-S., Hauser, C., Gundlach, J-P., Will, O., Hoffmann, P., Stahmer, L., Franzenburg, S., Knaack, H., Schumacher, U., Busch, H. & Sebens, S., 06.02.2024, In: CANCERS. 16, 4, 686.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. Lectin histochemical investigations of the distal gut of chicks with special emphasis on the follicle-associated epithelium

    Pohlmeyer, I., Jörns, J., Schumacher, U., Van Damme, E. J. M., Peumans, W. J., Pfüller, U. & Neumann, U., 04.2005, In: J VET MED A. 52, 3, p. 138-46 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. Tailor-made quantum dot and iron oxide based contrast agents for in vitro and in vivo tumor imaging.

    Pöselt, E., Schmidtke, C., Fischer, S., Peldschus, K., Salamon, J. M., Kloust, H., Tran, H., Pietsch, A., Heine, M., Adam, G., Schumacher, U., Wagener, C., Förster, S. & Weller, H., 2012, In: ACS NANO. 6, 4, p. 3346-3355 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters

    Prehm, P. & Schumacher, U., 01.10.2004, In: BIOCHEM PHARMACOL. 68, 7, p. 1401-10 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. Determination of liver-specific r2 * of a highly monodisperse USPIO by (59) Fe iron core-labeling in mice at 3 T MRI

    Raabe, N., Forberich, E., Freund, B., Bruns, O. T., Heine, M., Kaul, M. G., Tromsdorf, U., Herich, L., Nielsen, P., Reimer, R., Hohenberg, H., Weller, H., Schumacher, U., Adam, G. & Ittrich, H., 2015, In: CONTRAST MEDIA MOL I. 10, p. 153-62

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5

    Rathod, M., Franz, H., Beyersdorfer, V., Wanuske, M-T., Fischer, K. L., Hanns, P., Stüdle, C., Zimmermann, A., Buczak, K., Schinner, C. & Spindler, V., 01.04.2024, In: J CELL BIOL. 223, 4, p. e202305006

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. Nestin in the epididymis is expressed in vascular wall cells and is regulated during postnatal development and in case of testosterone deficiency

    Reckmann, A. N., Tomczyk, C. U. M., Davidoff, M. S., Michurina, T. V., Arnhold, S., Müller, D., Mietens, A. & Middendorff, R., 2018, In: PLOS ONE. 13, 6, p. e0194585

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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