Research ExplorerResearch UnitsInstitute of Biochemistry and Signal Transduction Publications

Institute of Biochemistry and Signal Transduction

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Publications

  1. 2024

  2. Multiple myeloma in the young: insights on prognosis, clinical features and treatment outcome derived from nationwide German registry data and a nested multicenter sample

    Kamili, A., Ahmadi, P., Leypoldt, L., Marquard, F., Schaefers, C., Kosch, R., Peters, F., Kusche, H., Zamrik, T., Hanoun, C., Seib, M., Shumilov, E., Leitner, T., Khandanpour, C., Bokemeyer, C., Weisel, K. & Ghandili, S., 18.07.2024, In: HAEMATOLOGICA.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway

    Ehm, P. A. H., Horn, S., Hoffer, K., Kriegs, M., Horn, M., Giehler, S., Nalaskowski, M., Rehbach, C., Horstmann, M. A. & Jücker, M., 12.07.2024, In: CELL COMMUN SIGNAL. 22, 1, p. 360

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. The Functional Roles of the Src Homology 2 Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 in the Pathogenesis of Human Diseases

    Müller, S. M. & Jücker, M., 11.05.2024, In: INT J MOL SCI. 25, 10, 5254.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  5. Pronucleotide Probes Reveal a Diverging Specificity for AMPylation vs UMPylation of Human and Bacterial Nucleotide Transferases

    Mostert, D., Bubeneck, W. A., Rauh, T., Kielkowski, P., Itzen, A., Jung, K. & Sieber, S. A., 05.03.2024, In: BIOCHEMISTRY-US. 63, 5, p. 651-659 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines

    Tian, L-Y., Smit, D. J., Popova, N. V., Horn, S., Velasquez, L. N., Huber, S. & Jucker, M., 11.02.2024, In: INT J MOL SCI. 25, 4, 2168.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3

    Geißert, R., Lammert, A., Wirth, S., Hönig, R., Lohfink, D., Unger, M., Pek, D., Schlüter, K., Scheftschik, T., Smit, D. J., Jücker, M., Menke, A. & Giehl, K., 30.01.2024, In: CELL COMMUN SIGNAL. 22, 1, p. 85

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Transcriptome-based identification of key actin-binding proteins associated with high metastatic potential in breast cancer

    Müller, C., Schmalfeldt, B., Müller, V., Schmalfeldt, B. & Windhorst, S., 2024, In: FRONT MOL BIOSCI. 11, p. 1440276

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. 2023

  10. Generating Patient-Derived HCC Cell Lines Suitable for Predictive In Vitro and In Vivo Drug Screening by Orthotopic Transplantation

    Staffeldt, L., Mattert, G., Riecken, K., Rövenstrunk, G., Volkmar, A., Heumann, A., Moustafa, M., Jücker, M., Fehse, B., Schumacher, U., Lüth, S. & Kah, J., 30.12.2023, In: CELLS-BASEL. 13, 1, 82.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. Structural basis for subversion of host cell actin cytoskeleton during Salmonella infection

    Yuan, B., Scholz, J., Wald, J., Thuenauer, R., Hennell James, R., Ellenberg, I., Windhorst, S., Faix, J. & Marlovits, T. C., 08.12.2023, In: SCI ADV. 9, 49, p. eadj5777

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3

    Höpfner, D., Cichy, A., Pogenberg, V., Krisp, C., Mezouar, S., Bach, N. C., Grotheer, J., Zarza, S. M., Martinez, E., Bonazzi, M., Feige, M. J., Sieber, S. A., Schlüter, H. & Itzen, A., 06.11.2023, In: COMMUN BIOL. 6, 1, p. 1124

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Cryo-EM structures of actin binding proteins as tool for drug discovery

    Dahlstroem, C., Paraschiakos, T., Sun, H. & Windhorst, S., 08.2023, In: BIOCHEM PHARMACOL. 214, p. 115680

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  14. Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases

    Ehm, P. A. H., Linnebacher, M., Block, A., Rehbach, C. & Jücker, M., 08.2023, In: CELL SIGNAL. 108, p. 110720

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis

    Kempska, J., Oliveira-Ferrer, L., Grottke, A., Qi, M., Alawi, M., Meyer, F., Borgmann, K., Hamester, F., Eylmann, K., Rossberg, M., Smit, D. J., Jücker, M., Laakmann, E., Witzel, I., Schmalfeldt, B., Müller, V. & Legler, K., 06.07.2023, In: FRONT ONCOL. 13, p. 1129682 1129682.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model

    Ehm, P., Rietow, R., Wegner, W., Bußmann, L., Kriegs, M., Dierck, K., Horn, S., Streichert, T., Horstmann, M. & Jücker, M., 06.07.2023, In: CELLS-BASEL. 12, 13, p. 1798

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. Activated Src kinases downstream of BCR-ABL and Flt3 induces proteasomal degradation of SHIP1 by phosphorylation of tyrosine 1021

    Ehm, P., Bettin, B. & Jücker, M., 06.2023, In: BBA-MOL CELL RES. 1870, 5, 119467.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Millisecond cryo-trapping by the spitrobot crystal plunger simplifies time-resolved crystallography

    Mehrabi, P., Sung, S., von Stetten, D., Prester, A., Hatton, C. E., Kleine-Döpke, S., Berkes, A., Gore, G., Leimkohl, J-P., Schikora, H., Kollewe, M., Rohde, H., Wilmanns, M., Tellkamp, F. & Schulz, E. C., 25.04.2023, In: NAT COMMUN. 14, 1, p. 2365

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b

    Kaspers, M. S., Pogenberg, V., Pett, C., Ernst, S., Ecker, F., Ochtrop, P., Groll, M., Hedberg, C. & Itzen, A., 19.04.2023, In: NAT COMMUN. 14, 1, p. 2245

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo

    Genduso, S., Freytag, V., Schetler, D., Kirchner, L., Schiecke, A., Maar, H., Wicklein, D., Gebauer, F., Bröker, K., Stürken, C., Milde-Langosch, K., Oliveira-Ferrer, L., Ricklefs, F. L., Ewald, F., Wolters-Eisfeld, G., Riecken, K., Unrau, L., Krause, L., Bohnenberger, H., Offermann, A., Perner, S., Sebens, S., Lamszus, K., Diehl, L., Linder, S., Jücker, M., Schumacher, U. & Lange, T., 17.03.2023, In: J HEMATOL ONCOL. 16, 1, 23.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells

    Küster, L., Paraschiakos, T., Karakurt, K. E., Schumacher, U., Diercks, B-P. & Windhorst, S., 27.02.2023, In: BIOSCIENCE REP. 43, 2, BSR20222150.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Ex Vivo Model of Neuroblastoma Plasticity

    Schäfer, P., Muhs, S., Turnbull, L., Garwal, P., Maar, H., Yorgan, T. A., Tolosa, E., Lange, T. & Windhorst, S., 17.02.2023, In: CANCERS. 15, 4, 1274.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. The Alarmone Diadenosine Tetraphosphate as a Cosubstrate for Protein AMPylation

    Frese, M., Saumer, P., Yuan, Y., Herzog, D., Höpfner, D., Itzen, A. & Marx, A., 13.02.2023, In: ANGEW CHEM INT EDIT. 62, 8, p. e202213279 e202213279.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism

    Tian, L-Y., Smit, D. J. & Jücker, M., 31.01.2023, In: INT J MOL SCI. 24, 3, 2652.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  25. Reduced expression and activity of patient-derived SHIP1 phosphatase domain mutants

    Ehm, P., Nelson, N., Giehler, S., Schaks, M., Bettin, B., Kirchmair, J. & Jücker, M., 01.2023, In: CELL SIGNAL. 101, 110485.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Sample Preparation for Time-Resolved Serial Crystallography: Practical Considerations

    Mehrabi, P. & Schulz, E. C., 2023, Advanced Methods in Structural Biology. Sousa, Â. & Passarinha, L. (eds.). 1 ed. New York, NY: Humana Press, p. 361-379 19 p. (Methods Mol Biol; vol. 2652).

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  27. 2022

  28. TIGIT blockade repolarizes AML-associated TIGIT+ M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis

    Brauneck, F., Fischer, B., Witt, M., Muschhammer, J., Oelrich, J., da Costa Avelar, P. H., Tsoka, S., Bullinger, L., Seubert, E., Smit, D. J., Bokemeyer, C., Ackermann, C., Wellbrock, J., Haag, F. & Fiedler, W., 12.2022, In: J IMMUNOTHER CANCER. 10, 12, e004794.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. Key Role of Hyaluronan Metabolism for the Development of Brain Metastases in Triple-Negative Breast Cancer

    Hamester, F., Stürken, C., Legler, K., Eylmann, K., Möller, K., Roßberg, M., Gorzelanny, C., Bauer, A. T., Windhorst, S., Schmalfeldt, B., Laakmann, E., Müller, V., Witzel, I. & Oliveira-Ferrer, L., 18.10.2022, In: CELLS-BASEL. 11, 20, 3275.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. JAK2-V617F is a negative regulation factor of SHIP1 protein and thus influences the AKT signaling pathway in patients with Myeloproliferative Neoplasm (MPN)

    Glück, M., Dally, L., Jücker, M. & Ehm, P., 08.2022, In: INT J BIOCHEM CELL B. 149, 106229.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer

    Elakad, O., Häupl, B., Labitzky, V., Yao, S., Küffer, S., von Hammerstein-Equord, A., Danner, B. C., Jücker, M., Urlaub, H., Lange, T., Ströbel, P., Oellerich, T. & Bohnenberger, H., 19.07.2022, In: NPJ PRECIS ONCOL. 6, 1, 52.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Investigation of the function of the PI3-Kinase / AKT signaling pathway for leukemogenesis and therapy of acute childhood lymphoblastic leukemia (ALL)

    Ehm, P., Grottke, A., Bettin, B. & Jücker, M., 05.2022, In: CELL SIGNAL. 93, 110301.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM+ and CD90+ Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model

    Moustafa, M., Dähling, K-K., Günther, A., Riebandt, L., Smit, D. J., Riecken, K., Schröder, C., Zhuang, R., Krech, T., Kriegs, M., Fehse, B., Izbicki, J., Fischer, L., Nashan, B., Li, J. & Jücker, M., 08.04.2022, In: CANCERS. 14, 8, 1882.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. The role of sphingosine-1-phosphate in bone remodeling and osteoporosis

    Grewe, J. M., Knapstein, P-R., Donat, A., Jiang, S., Smit, D. J., Xie, W. & Keller, J., 08.04.2022, In: BONE RES. 10, 1, 34.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  35. Revisiting AMPylation through the lens of Fic enzymes

    Gulen, B. & Itzen, A., 04.2022, In: TRENDS MICROBIOL. 30, 4, p. 350-363 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  36. DIAPH1 facilitates paclitaxel-mediated cytotoxicity of ovarian cancer cells

    Flat, W., Borowski, S., Paraschiakos, T., Blechner, C. & Windhorst, S., 03.2022, In: BIOCHEM PHARMACOL. 197, 114898.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. MicroRNAs: Emerging Regulators of Metastatic Bone Disease in Breast Cancer

    Haider, M-T., Smit, D. J. & Taipaleenmäki, H., 30.01.2022, In: CANCERS. 14, 3, 729.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  38. The Functional Role of Extracellular Matrix Proteins in Cancer

    Popova, N. V. & Jücker, M., 04.01.2022, In: CANCERS. 14, 1, 238.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  39. AKT Isoforms as a Target in Cancer and Immunotherapy

    Smit, D. J. & Jücker, M., 2022, PI3K and AKT Isoforms in Immunity. Dominguez-Villar, M. (ed.). 1 ed. Cham: Springer, p. 409-436 27 p. (Current Topics in Microbiology and Immunology; vol. 436).

    Research output: SCORING: Contribution to book/anthology › Chapter › Research › peer-review

  40. 2021

  41. Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density

    Middelkamp, M., Ruck, L., Krisp, C., Sumisławski, P., Mohammadi, B., Dottermusch, M., Meister, V., Küster, L., Schlüter, H., Windhorst, S. & Neumann, J. E., 20.11.2021, In: ACTA NEUROPATHOL COM. 9, 1, p. 185

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. Rcf proteins and their differential specificity for respiratory chain complexes: A unique role for Rcf2 on oxygen sensitive supercomplexes?

    Homberg, B., Römpler, K., Wissel, M., Callegari, S. & Deckers, M., 11.2021, In: BBA-MOL CELL RES. 1868, 12, 119133.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. High Serum Levels of Wnt Signaling Antagonist Dickkopf-Related Protein 1 Are Associated with Impaired Overall Survival and Recurrence in Esophageal Cancer Patients

    Ramirez, J. G., Smit, D. J., Viol, F., Schrader, J., Ghadban, T., Pantel, K., Izbicki, J. R. & Reeh, M., 04.10.2021, In: CANCERS. 13, 19, 4980.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. Oncogenic activity and cellular functionality of melanoma associated antigen A3

    Schäfer, P., Paraschiakos, T. & Windhorst, S., 10.2021, In: BIOCHEM PHARMACOL. 192, 114700.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  45. AKT1 and PTEN show the highest affinities among phosphoinositide binding proteins for the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2

    Nelson, N., Razeto, A., Gilardi, A., Grättinger, M., Kirchmair, J. & Jücker, M., 03.09.2021, In: BIOCHEM BIOPH RES CO. 568, p. 110-115 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer

    Hofmann, B. T., Picksak, A-S., Kwiatkowski, M., Grupp, K., Jücker, M., Bachmann, K., Mercanoglu, B., Izbicki, J. R., Kahlert, C., Bockhorn, M., Güngör, C., Ewald, F. & Wolters-Eisfeld, G., 18.08.2021, In: GLYCOBIOLOGY. 2021, cwab088.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. SopD from Salmonella specifically inactivates Rab8

    Savitskiy, S. & Itzen, A., 08.2021, In: BBA-PROTEINS PROTEOM. 1869, 8, p. 140661

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. Mechanism of BIP-4 mediated inhibition of InsP3Kinase-A

    Paraschiakos, T., Flat, W., Chen, Y., Kirchmair, J. & Windhorst, S., 30.07.2021, In: BIOSCIENCE REP. 41, 7, BSR20211259.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. Erratum: Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation

    Höpfner, D., Fauser, J., Kaspers, M. S., Pett, C., Hedberg, C. & Itzen, A., 23.07.2021, In: ISCIENCE. 24, 7, p. 102731

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  50. Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia

    Ecker, V., Stumpf, M., Brandmeier, L., Neumayer, T., Pfeuffer, L., Engleitner, T., Ringshausen, I., Nelson, N., Jücker, M., Wanninger, S., Zenz, T., Wendtner, C., Manske, K., Steiger, K., Rad, R., Müschen, M., Ruland, J. & Buchner, M., 10.06.2021, In: NAT COMMUN. 12, 1, p. 3526

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. Circulating tumor cells as a promising target for individualized drug susceptibility tests in cancer therapy

    Smit, D. J., Pantel, K. & Jücker, M., 06.2021, In: BIOCHEM PHARMACOL. 188, p. 114589

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  52. Current Advances in Covalent Stabilization of Macromolecular Complexes for Structural Biology

    Fauser, J., Itzen, A. & Gulen, B., 19.05.2021, In: BIOCONJUGATE CHEM. 32, 5, p. 879-890 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  53. AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review

    Hinz, N. & Jücker, M., 11.05.2021, In: CANCERS. 13, 10, p. 2287

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  54. 2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: identification of a new and potent inhibitor

    Löhndorf, A., Hosang, L., Dohle, W., Odoardi, F., Waschkowski, S-A., Rosche, A., Bauche, A., Winzer, R., Tolosa, E., Windhorst, S., Marry, S., Flügel, A., Potter, B. V. L., Diercks, B-P. & Guse, A. H., 05.2021, In: BBA-MOL CELL RES. 1868, 6, p. 118988

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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