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Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study

Standard

Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study. / Golchert, Johannes; Roehr, Susanne; Luck, Tobias; Wagner, Michael; Fuchs, Angela; Wiese, Birgitt; van den Bussche, Hendrik; Brettschneider, Christian; Werle, Jochen; Bickel, Horst; Pentzek, Michael; Oey, Anke; Eisele, Marion; König, Hans-Helmut; Weyerer, Siegfried; Mösch, Edelgard; Maier, Wolfgang; Scherer, Martin; Heser, Kathrin; Riedel-Heller, Steffi G.

in: J ALZHEIMERS DIS, Jahrgang 69, Nr. 3, 06.2019, S. 857-869.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Golchert, J, Roehr, S, Luck, T, Wagner, M, Fuchs, A, Wiese, B, van den Bussche, H, Brettschneider, C, Werle, J, Bickel, H, Pentzek, M, Oey, A, Eisele, M, König, H-H, Weyerer, S, Mösch, E, Maier, W, Scherer, M, Heser, K & Riedel-Heller, SG 2019, 'Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study', J ALZHEIMERS DIS, Jg. 69, Nr. 3, S. 857-869. https://doi.org/10.3233/JAD-180949

APA

Golchert, J., Roehr, S., Luck, T., Wagner, M., Fuchs, A., Wiese, B., van den Bussche, H., Brettschneider, C., Werle, J., Bickel, H., Pentzek, M., Oey, A., Eisele, M., König, H-H., Weyerer, S., Mösch, E., Maier, W., Scherer, M., Heser, K., & Riedel-Heller, S. G. (2019). Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study. J ALZHEIMERS DIS, 69(3), 857-869. https://doi.org/10.3233/JAD-180949

Vancouver

Golchert J, Roehr S, Luck T, Wagner M, Fuchs A, Wiese B et al. Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study. J ALZHEIMERS DIS. 2019 Jun;69(3):857-869. https://doi.org/10.3233/JAD-180949

Bibtex

@article{b6ce65169b3b4f32b2457ba305c477ad,
title = "Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study",
abstract = "BACKGROUND: Sex differences in verbal episodic memory function have been widely reported. However, sex-specific effects on rates of episodic memory decline remain controversial, and evidence is particularly scarce in the oldest-old population.OBJECTIVE: We aimed to investigate sex differences in trajectories of episodic memory performance in oldest-old individuals.METHODS: Based on 13-year longitudinal data with 9 follow-up assessments of a large sample of cognitively unimpaired old (75+) primary care patients (n = 3,254) participating in the German AgeCoDe/AgeQualiDe study, we used linear mixed effects analyses to model sex-specific trajectories of change in verbal episodic memory while accounting for covarying factors.RESULTS: We found that even in the highest age group women outperformed men in immediate (b = -1.71, p < 0.001) and delayed (b = -0.85, p < 0.001) free recall conditions. Associated late-life trajectories, however, did not differ significantly between the sexes. We further demonstrated that younger age, higher education, and an absence of depressive symptoms predicted better performance in both sexes. In contrast, past occurrences of stroke and APOE ɛ4 carrier status showed a negative relation to test scores.CONCLUSION: Our findings confirm previous research suggesting that women perform better in verbal episodic memory tests. We add that this advantage is still present in the oldest-old age groups. Our results indicate that sociodemographic and health related factors are as important as genetically based APOE ɛ4 carrier status in the prediction of normal cognitive development in advanced old age.",
keywords = "Journal Article",
author = "Johannes Golchert and Susanne Roehr and Tobias Luck and Michael Wagner and Angela Fuchs and Birgitt Wiese and {van den Bussche}, Hendrik and Christian Brettschneider and Jochen Werle and Horst Bickel and Michael Pentzek and Anke Oey and Marion Eisele and Hans-Helmut K{\"o}nig and Siegfried Weyerer and Edelgard M{\"o}sch and Wolfgang Maier and Martin Scherer and Kathrin Heser and Riedel-Heller, {Steffi G}",
year = "2019",
month = jun,
doi = "10.3233/JAD-180949",
language = "English",
volume = "69",
pages = "857--869",
journal = "J ALZHEIMERS DIS",
issn = "1387-2877",
publisher = "IOS Press",
number = "3",

}

RIS

TY - JOUR

T1 - Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study

AU - Golchert, Johannes

AU - Roehr, Susanne

AU - Luck, Tobias

AU - Wagner, Michael

AU - Fuchs, Angela

AU - Wiese, Birgitt

AU - van den Bussche, Hendrik

AU - Brettschneider, Christian

AU - Werle, Jochen

AU - Bickel, Horst

AU - Pentzek, Michael

AU - Oey, Anke

AU - Eisele, Marion

AU - König, Hans-Helmut

AU - Weyerer, Siegfried

AU - Mösch, Edelgard

AU - Maier, Wolfgang

AU - Scherer, Martin

AU - Heser, Kathrin

AU - Riedel-Heller, Steffi G

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND: Sex differences in verbal episodic memory function have been widely reported. However, sex-specific effects on rates of episodic memory decline remain controversial, and evidence is particularly scarce in the oldest-old population.OBJECTIVE: We aimed to investigate sex differences in trajectories of episodic memory performance in oldest-old individuals.METHODS: Based on 13-year longitudinal data with 9 follow-up assessments of a large sample of cognitively unimpaired old (75+) primary care patients (n = 3,254) participating in the German AgeCoDe/AgeQualiDe study, we used linear mixed effects analyses to model sex-specific trajectories of change in verbal episodic memory while accounting for covarying factors.RESULTS: We found that even in the highest age group women outperformed men in immediate (b = -1.71, p < 0.001) and delayed (b = -0.85, p < 0.001) free recall conditions. Associated late-life trajectories, however, did not differ significantly between the sexes. We further demonstrated that younger age, higher education, and an absence of depressive symptoms predicted better performance in both sexes. In contrast, past occurrences of stroke and APOE ɛ4 carrier status showed a negative relation to test scores.CONCLUSION: Our findings confirm previous research suggesting that women perform better in verbal episodic memory tests. We add that this advantage is still present in the oldest-old age groups. Our results indicate that sociodemographic and health related factors are as important as genetically based APOE ɛ4 carrier status in the prediction of normal cognitive development in advanced old age.

AB - BACKGROUND: Sex differences in verbal episodic memory function have been widely reported. However, sex-specific effects on rates of episodic memory decline remain controversial, and evidence is particularly scarce in the oldest-old population.OBJECTIVE: We aimed to investigate sex differences in trajectories of episodic memory performance in oldest-old individuals.METHODS: Based on 13-year longitudinal data with 9 follow-up assessments of a large sample of cognitively unimpaired old (75+) primary care patients (n = 3,254) participating in the German AgeCoDe/AgeQualiDe study, we used linear mixed effects analyses to model sex-specific trajectories of change in verbal episodic memory while accounting for covarying factors.RESULTS: We found that even in the highest age group women outperformed men in immediate (b = -1.71, p < 0.001) and delayed (b = -0.85, p < 0.001) free recall conditions. Associated late-life trajectories, however, did not differ significantly between the sexes. We further demonstrated that younger age, higher education, and an absence of depressive symptoms predicted better performance in both sexes. In contrast, past occurrences of stroke and APOE ɛ4 carrier status showed a negative relation to test scores.CONCLUSION: Our findings confirm previous research suggesting that women perform better in verbal episodic memory tests. We add that this advantage is still present in the oldest-old age groups. Our results indicate that sociodemographic and health related factors are as important as genetically based APOE ɛ4 carrier status in the prediction of normal cognitive development in advanced old age.

KW - Journal Article

U2 - 10.3233/JAD-180949

DO - 10.3233/JAD-180949

M3 - SCORING: Journal article

C2 - 31127762

VL - 69

SP - 857

EP - 869

JO - J ALZHEIMERS DIS

JF - J ALZHEIMERS DIS

SN - 1387-2877

IS - 3

ER -