Voxel-based lesion-symptom mapping of stroke lesions underlying somatosensory deficits
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Voxel-based lesion-symptom mapping of stroke lesions underlying somatosensory deficits. / Meyer, Sarah; Kessner, Simon S; Cheng, Bastian; Bönstrup, Marlene; Schulz, Robert; Hummel, Friedhelm C; De Bruyn, Nele; Peeters, Andre; Van Pesch, Vincent; Duprez, Thierry; Sunaert, Stefan; Schrooten, Maarten; Feys, Hilde; Gerloff, Christian; Thomalla, Götz; Thijs, Vincent; Verheyden, Geert.
in: NEUROIMAGE-CLIN, Jahrgang 10, 2016, S. 257-66.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Voxel-based lesion-symptom mapping of stroke lesions underlying somatosensory deficits
AU - Meyer, Sarah
AU - Kessner, Simon S
AU - Cheng, Bastian
AU - Bönstrup, Marlene
AU - Schulz, Robert
AU - Hummel, Friedhelm C
AU - De Bruyn, Nele
AU - Peeters, Andre
AU - Van Pesch, Vincent
AU - Duprez, Thierry
AU - Sunaert, Stefan
AU - Schrooten, Maarten
AU - Feys, Hilde
AU - Gerloff, Christian
AU - Thomalla, Götz
AU - Thijs, Vincent
AU - Verheyden, Geert
PY - 2016
Y1 - 2016
N2 - The aim of this study was to investigate the relationship between stroke lesion location and the resulting somatosensory deficit. We studied exteroceptive and proprioceptive somatosensory symptoms and stroke lesions in 38 patients with first-ever acute stroke. The Erasmus modified Nottingham Sensory Assessment was used to clinically evaluate somatosensory functioning in the arm and hand within the first week after stroke onset. Additionally, more objective measures such as the perceptual threshold of touch and somatosensory evoked potentials were recorded. Non-parametric voxel-based lesion-symptom mapping was performed to investigate lesion contribution to different somatosensory deficits in the upper limb. Additionally, structural connectivity of brain areas that demonstrated the strongest association with somatosensory symptoms was determined, using probabilistic fiber tracking based on diffusion tensor imaging data from a healthy age-matched sample. Voxels with a significant association to somatosensory deficits were clustered in two core brain regions: the central parietal white matter, also referred to as the sensory component of the superior thalamic radiation, and the parietal operculum close to the insular cortex, representing the secondary somatosensory cortex. Our objective recordings confirmed findings from clinical assessments. Probabilistic tracking connected the first region to thalamus, internal capsule, brain stem, postcentral gyrus, cerebellum, and frontal pathways, while the second region demonstrated structural connections to thalamus, insular and primary somatosensory cortex. This study reveals that stroke lesions in the sensory fibers of the superior thalamocortical radiation and the parietal operculum are significantly associated with multiple exteroceptive and proprioceptive deficits in the arm and hand.
AB - The aim of this study was to investigate the relationship between stroke lesion location and the resulting somatosensory deficit. We studied exteroceptive and proprioceptive somatosensory symptoms and stroke lesions in 38 patients with first-ever acute stroke. The Erasmus modified Nottingham Sensory Assessment was used to clinically evaluate somatosensory functioning in the arm and hand within the first week after stroke onset. Additionally, more objective measures such as the perceptual threshold of touch and somatosensory evoked potentials were recorded. Non-parametric voxel-based lesion-symptom mapping was performed to investigate lesion contribution to different somatosensory deficits in the upper limb. Additionally, structural connectivity of brain areas that demonstrated the strongest association with somatosensory symptoms was determined, using probabilistic fiber tracking based on diffusion tensor imaging data from a healthy age-matched sample. Voxels with a significant association to somatosensory deficits were clustered in two core brain regions: the central parietal white matter, also referred to as the sensory component of the superior thalamic radiation, and the parietal operculum close to the insular cortex, representing the secondary somatosensory cortex. Our objective recordings confirmed findings from clinical assessments. Probabilistic tracking connected the first region to thalamus, internal capsule, brain stem, postcentral gyrus, cerebellum, and frontal pathways, while the second region demonstrated structural connections to thalamus, insular and primary somatosensory cortex. This study reveals that stroke lesions in the sensory fibers of the superior thalamocortical radiation and the parietal operculum are significantly associated with multiple exteroceptive and proprioceptive deficits in the arm and hand.
KW - Aged
KW - Aged, 80 and over
KW - Arm
KW - Brain
KW - Brain Ischemia
KW - Diffusion Tensor Imaging
KW - Female
KW - Hand
KW - Humans
KW - Intracranial Hemorrhages
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Proprioception
KW - Sensory Thresholds
KW - Stroke
KW - Touch Perception
KW - White Matter
KW - Journal Article
U2 - 10.1016/j.nicl.2015.12.005
DO - 10.1016/j.nicl.2015.12.005
M3 - SCORING: Journal article
C2 - 26900565
VL - 10
SP - 257
EP - 266
JO - NEUROIMAGE-CLIN
JF - NEUROIMAGE-CLIN
SN - 2213-1582
ER -
