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Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients

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Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. / Staquicini, Fernanda I; Cardó-Vila, Marina; Kolonin, Mikhail G; Trepel, Martin; Edwards, Julianna K; Nunes, Diana N; Sergeeva, Anna; Efstathiou, Eleni; Sun, Jessica; Almeida, Nalvo F; Tu, Shi-Ming; Botz, Gregory H; Wallace, Michael J; O'Connell, David J; Krajewski, Stan; Gershenwald, Jeffrey E; Molldrem, Jeffrey J; Flamm, Anne L; Koivunen, Erkki; Pentz, Rebecca D; Dias-Neto, Emmanuel; Setubal, João C; Cahill, Dolores J; Troncoso, Patricia; Do, Kim-Ahn; Logothetis, Christopher J; Sidman, Richard L; Pasqualini, Renata; Arap, Wadih.

in: P NATL ACAD SCI USA, Jahrgang 108, Nr. 46, 15.11.2011, S. 18637-42.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Staquicini, FI, Cardó-Vila, M, Kolonin, MG, Trepel, M, Edwards, JK, Nunes, DN, Sergeeva, A, Efstathiou, E, Sun, J, Almeida, NF, Tu, S-M, Botz, GH, Wallace, MJ, O'Connell, DJ, Krajewski, S, Gershenwald, JE, Molldrem, JJ, Flamm, AL, Koivunen, E, Pentz, RD, Dias-Neto, E, Setubal, JC, Cahill, DJ, Troncoso, P, Do, K-A, Logothetis, CJ, Sidman, RL, Pasqualini, R & Arap, W 2011, 'Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients', P NATL ACAD SCI USA, Jg. 108, Nr. 46, S. 18637-42. https://doi.org/10.1073/pnas.1114503108

APA

Staquicini, F. I., Cardó-Vila, M., Kolonin, M. G., Trepel, M., Edwards, J. K., Nunes, D. N., Sergeeva, A., Efstathiou, E., Sun, J., Almeida, N. F., Tu, S-M., Botz, G. H., Wallace, M. J., O'Connell, D. J., Krajewski, S., Gershenwald, J. E., Molldrem, J. J., Flamm, A. L., Koivunen, E., ... Arap, W. (2011). Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. P NATL ACAD SCI USA, 108(46), 18637-42. https://doi.org/10.1073/pnas.1114503108

Vancouver

Staquicini FI, Cardó-Vila M, Kolonin MG, Trepel M, Edwards JK, Nunes DN et al. Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. P NATL ACAD SCI USA. 2011 Nov 15;108(46):18637-42. https://doi.org/10.1073/pnas.1114503108

Bibtex

@article{669b78f5848045df93de035f2a493bf7,
title = "Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients",
abstract = "Molecules differentially expressed in blood vessels among organs or between damaged and normal tissues, are attractive therapy targets; however, their identification within the human vasculature is challenging. Here we screened a peptide library in cancer patients to uncover ligand-receptors common or specific to certain vascular beds. Surveying ~2.35 x 10(6) motifs recovered from biopsies yielded a nonrandom distribution, indicating that systemic tissue targeting is feasible. High-throughput analysis by similarity search, protein arrays, and affinity chromatography revealed four native ligand-receptors, three of which were previously unrecognized. Two are shared among multiple tissues (integrin α4/annexin A4 and cathepsin B/apolipoprotein E3) and the other two have a restricted and specific distribution in normal tissue (prohibitin/annexin A2 in white adipose tissue) or cancer (RAGE/leukocyte proteinase-3 in bone metastases). These findings provide vascular molecular markers for biotechnology and medical applications.",
keywords = "Amino Acid Motifs, Annexin A4, Apolipoprotein E3, Biopsy, Blood Vessels, Bone Marrow, Cathepsin B, Gene Expression Regulation, Neoplastic, Humans, Integrin alpha4, Ligands, Neoplasms, Neovascularization, Pathologic, Obesity, Peptide Library, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.",
author = "Staquicini, {Fernanda I} and Marina Card{\'o}-Vila and Kolonin, {Mikhail G} and Martin Trepel and Edwards, {Julianna K} and Nunes, {Diana N} and Anna Sergeeva and Eleni Efstathiou and Jessica Sun and Almeida, {Nalvo F} and Shi-Ming Tu and Botz, {Gregory H} and Wallace, {Michael J} and O'Connell, {David J} and Stan Krajewski and Gershenwald, {Jeffrey E} and Molldrem, {Jeffrey J} and Flamm, {Anne L} and Erkki Koivunen and Pentz, {Rebecca D} and Emmanuel Dias-Neto and Setubal, {Jo{\~a}o C} and Cahill, {Dolores J} and Patricia Troncoso and Kim-Ahn Do and Logothetis, {Christopher J} and Sidman, {Richard L} and Renata Pasqualini and Wadih Arap",
year = "2011",
month = nov,
day = "15",
doi = "10.1073/pnas.1114503108",
language = "English",
volume = "108",
pages = "18637--42",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "46",

}

RIS

TY - JOUR

T1 - Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients

AU - Staquicini, Fernanda I

AU - Cardó-Vila, Marina

AU - Kolonin, Mikhail G

AU - Trepel, Martin

AU - Edwards, Julianna K

AU - Nunes, Diana N

AU - Sergeeva, Anna

AU - Efstathiou, Eleni

AU - Sun, Jessica

AU - Almeida, Nalvo F

AU - Tu, Shi-Ming

AU - Botz, Gregory H

AU - Wallace, Michael J

AU - O'Connell, David J

AU - Krajewski, Stan

AU - Gershenwald, Jeffrey E

AU - Molldrem, Jeffrey J

AU - Flamm, Anne L

AU - Koivunen, Erkki

AU - Pentz, Rebecca D

AU - Dias-Neto, Emmanuel

AU - Setubal, João C

AU - Cahill, Dolores J

AU - Troncoso, Patricia

AU - Do, Kim-Ahn

AU - Logothetis, Christopher J

AU - Sidman, Richard L

AU - Pasqualini, Renata

AU - Arap, Wadih

PY - 2011/11/15

Y1 - 2011/11/15

N2 - Molecules differentially expressed in blood vessels among organs or between damaged and normal tissues, are attractive therapy targets; however, their identification within the human vasculature is challenging. Here we screened a peptide library in cancer patients to uncover ligand-receptors common or specific to certain vascular beds. Surveying ~2.35 x 10(6) motifs recovered from biopsies yielded a nonrandom distribution, indicating that systemic tissue targeting is feasible. High-throughput analysis by similarity search, protein arrays, and affinity chromatography revealed four native ligand-receptors, three of which were previously unrecognized. Two are shared among multiple tissues (integrin α4/annexin A4 and cathepsin B/apolipoprotein E3) and the other two have a restricted and specific distribution in normal tissue (prohibitin/annexin A2 in white adipose tissue) or cancer (RAGE/leukocyte proteinase-3 in bone metastases). These findings provide vascular molecular markers for biotechnology and medical applications.

AB - Molecules differentially expressed in blood vessels among organs or between damaged and normal tissues, are attractive therapy targets; however, their identification within the human vasculature is challenging. Here we screened a peptide library in cancer patients to uncover ligand-receptors common or specific to certain vascular beds. Surveying ~2.35 x 10(6) motifs recovered from biopsies yielded a nonrandom distribution, indicating that systemic tissue targeting is feasible. High-throughput analysis by similarity search, protein arrays, and affinity chromatography revealed four native ligand-receptors, three of which were previously unrecognized. Two are shared among multiple tissues (integrin α4/annexin A4 and cathepsin B/apolipoprotein E3) and the other two have a restricted and specific distribution in normal tissue (prohibitin/annexin A2 in white adipose tissue) or cancer (RAGE/leukocyte proteinase-3 in bone metastases). These findings provide vascular molecular markers for biotechnology and medical applications.

KW - Amino Acid Motifs

KW - Annexin A4

KW - Apolipoprotein E3

KW - Biopsy

KW - Blood Vessels

KW - Bone Marrow

KW - Cathepsin B

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Integrin alpha4

KW - Ligands

KW - Neoplasms

KW - Neovascularization, Pathologic

KW - Obesity

KW - Peptide Library

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, Non-P.H.S.

U2 - 10.1073/pnas.1114503108

DO - 10.1073/pnas.1114503108

M3 - SCORING: Journal article

C2 - 22049339

VL - 108

SP - 18637

EP - 18642

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 46

ER -